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Volumn , Issue SEP, 2013, Pages

Targeting the endocannabinoid system to treat haunting traumatic memories

Author keywords

Anxiety disorders; Endocannabinoids; Extinction learning; Memory; PTSD rat

Indexed keywords

CANNABIDIOL; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABIS; DRONABINOL; ENDOCANNABINOID; NABILONE;

EID: 84884665824     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2013.00124     Document Type: Article
Times cited : (8)

References (38)
  • 1
    • 78650321250 scopus 로고    scopus 로고
    • Cannabinoids modulate hippocampal memory and plasticity
    • doi: 10.1002/hipo.20711
    • Abush, H., and Akirav, I. (2010). Cannabinoids modulate hippocampal memory and plasticity. Hippocampus 20, 1126-1138. doi: 10.1002/hipo.20711
    • (2010) Hippocampus , vol.20 , pp. 1126-1138
    • Abush, H.1    Akirav, I.2
  • 2
    • 84879421380 scopus 로고    scopus 로고
    • Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory
    • doi: 10.1038/npp.2013.51
    • Abush, H., and Akirav, I. (2013). Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory. Neuropsychopharmacology 38, 521-534. doi: 10.1038/npp.2013.51
    • (2013) Neuropsychopharmacology , vol.38 , pp. 521-534
    • Abush, H.1    Akirav, I.2
  • 3
    • 84857757278 scopus 로고    scopus 로고
    • Glucocorticoids interact with the hippocam-pal endocannabinoid system in impairing retrieval of contextual fear memory
    • doi: 10.1073/pnas.1200742109
    • Atsak, P., Hauer, D., Campolongo, P., Schelling, G., McGaugh, J. L., and Roozendaal, B. (2012a). Glucocorticoids interact with the hippocam-pal endocannabinoid system in impairing retrieval of contextual fear memory. Proc. Natl. Acad. Sci. U.S.A. 109, 3504-3509. doi: 10.1073/pnas.1200742109
    • (2012) Proc. Natl. Acad. Sci. U.S.A , vol.109 , pp. 3504-3509
    • Atsak, P.1    Hauer, D.2    Campolongo, P.3    Schelling, G.4    McGaugh, J.L.5    Roozendaal, B.6
  • 4
    • 84857126806 scopus 로고    scopus 로고
    • Role of the endocannabinoid system in regulating glucocorticoid effects on memory for emotional experiences
    • doi: 10.1016/j.neuroscience.2011.08.047
    • Atsak, P., Roozendaal, B., and Campolongo, P. (2012b). Role of the endocannabinoid system in regulating glucocorticoid effects on memory for emotional experiences. Neuroscience 204, 104-116. doi: 10.1016/j.neuroscience.2011.08.047
    • (2012) Neuroscience , vol.204 , pp. 104-116
    • Atsak, P.1    Roozendaal, B.2    Campolongo, P.3
  • 5
    • 53649087673 scopus 로고    scopus 로고
    • Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats
    • doi: 10.1016/j.euroneuro.2008.07.001
    • Bitencourt, R. M., Pamplona, F. A., and Takahashi, R. N. (2008). Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats. Eur. Neuropsychopharmacol. 18, 849-859. doi: 10.1016/j.euroneuro.2008.07.001
    • (2008) Eur. Neuropsychopharmacol , vol.18 , pp. 849-859
    • Bitencourt, R.M.1    Pamplona, F.A.2    Takahashi, R.N.3
  • 6
    • 80053243206 scopus 로고    scopus 로고
    • Cannabis use among military veterans after residential treatment for posttraumatic stress disorder
    • doi: 10.1037/a0021945
    • Bonn-Miller, M. O., Vujanovic, A. A., and Drescher, K. D. (2011).Cannabis use among military veterans after residential treatment for posttraumatic stress disorder. Psychol. Addict. Behav. 25, 485-491. doi: 10.1037/a0021945
    • (2011) Psychol. Addict. Behav , vol.25 , pp. 485-491
    • Bonn-Miller, M.O.1    Vujanovic, A.A.2    Drescher, K.D.3
  • 7
    • 84878604116 scopus 로고    scopus 로고
    • Novelty-induced emotional arousal modulates cannabinoid effects on recognition memory and adrenocortical activity
    • doi: 10.1038/npp.2013.26
    • Campolongo, P., Morena, M., Scaccianoce, S., Trezza, V., Chiarotti, F., Schelling, G., et al. (2013). Novelty-induced emotional arousal modulates cannabinoid effects on recognition memory and adrenocortical activity. Neuropsychopharmacology 38, 1276-1286. doi: 10.1038/npp.2013.26
    • (2013) Neuropsychopharmacology , vol.38 , pp. 1276-1286
    • Campolongo, P.1    Morena, M.2    Scaccianoce, S.3    Trezza, V.4    Chiarotti, F.5    Schelling, G.6
  • 8
    • 63849228542 scopus 로고    scopus 로고
    • Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory
    • doi: 10.1073/pnas.0900835106
    • Campolongo, P., Roozendaal, B., Trezza, V., Hauer, D., Schelling, G., McGaugh, J. L., et al. (2009). Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory. Proc. Natl. Acad. Sci. U.S.A. 106, 4888-4893. doi: 10.1073/pnas.0900835106
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 4888-4893
    • Campolongo, P.1    Roozendaal, B.2    Trezza, V.3    Hauer, D.4    Schelling, G.5    McGaugh, J.L.6
  • 9
    • 84871689359 scopus 로고    scopus 로고
    • Predator threat stress promotes long lasting anxiety-like behaviors and modulates synaptophysin and CB1 receptors expression in brain areas associated with PTSD symptoms
    • doi: 10.1016/j.neulet.2012.11.016
    • Campos, A. C., Ferreira, F. R., da Silva, W. A. Jr., and Guimarães, F. S. (2013). Predator threat stress promotes long lasting anxiety-like behaviors and modulates synaptophysin and CB1 receptors expression in brain areas associated with PTSD symptoms. Neurosci. Lett. 533, 34-38. doi: 10.1016/j.neulet.2012.11.016
    • (2013) Neurosci. Lett , vol.533 , pp. 34-38
    • Campos, A.C.1    Ferreira, F.R.2    da Silva Jr., W.A.3    Guimarães, F.S.4
  • 10
    • 84866942852 scopus 로고    scopus 로고
    • Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors
    • doi: 10.1016/j.jpsychires.2012.08.012
    • Campos, A. C., Ferreira, F. R., and Guimarães, F. S. (2012). Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors. J. Psychiatr. Res. 46, 1501-1510. doi: 10.1016/j.jpsychires.2012.08.012
    • (2012) J. Psychiatr. Res , vol.46 , pp. 1501-1510
    • Campos, A.C.1    Ferreira, F.R.2    Guimarães, F.S.3
  • 11
    • 13944267958 scopus 로고    scopus 로고
    • Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear
    • doi: 10.1038/sj.npp.1300655
    • Chhatwal, J. P., Davis, M., Maguschak, K. A., and Ressler, K. J. (2005). Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear. Neuropsychopharmacology 30, 516-524. doi: 10.1038/sj.npp.1300655
    • (2005) Neuropsychopharmacology , vol.30 , pp. 516-524
    • Chhatwal, J.P.1    Davis, M.2    Maguschak, K.A.3    Ressler, K.J.4
  • 12
    • 80053291929 scopus 로고    scopus 로고
    • Posttraumatic stress disorder and cannabis use in a nationally representative sample
    • doi: 10.1037/a0023076
    • Cougle, J. R., Bonn-Miller, M. O., Vujanovic, A. A., Zvolensky, M. J., and Hawkins, K. A. (2011). Posttraumatic stress disorder and cannabis use in a nationally representative sample. Psychol. Addict. Behav. 25, 554-558. doi: 10.1037/a0023076
    • (2011) Psychol. Addict. Behav , vol.25 , pp. 554-558
    • Cougle, J.R.1    Bonn-Miller, M.O.2    Vujanovic, A.A.3    Zvolensky, M.J.4    Hawkins, K.A.5
  • 13
    • 84876462372 scopus 로고    scopus 로고
    • Cannabidiol enhances consolidation of explicit fear extinction in humans
    • doi: 10.1007/s00213-012-2955-y
    • Das, R. K., Kamboj, S. K., Ramadas, M., Yogan, K., Gupta, V., Redman, E., et al. (2013). Cannabidiol enhances consolidation of explicit fear extinction in humans. Psychopharmacology (Berl.) 226, 781-792. doi: 10.1007/s00213-012-2955-y
    • (2013) Psychopharmacology (Berl.) , vol.226 , pp. 781-792
    • Das, R.K.1    Kamboj, S.K.2    Ramadas, M.3    Yogan, K.4    Gupta, V.5    Redman, E.6
  • 14
    • 4043102043 scopus 로고    scopus 로고
    • Intrusive re-experiencing in post-traumatic stress disorder: Phenomenology, theory, and therapy
    • doi: 10.1080/09658210444000025
    • Ehlers, A., Hackmann, A., and Michael, T. (2004). Intrusive re-experiencing in post-traumatic stress disorder: phenomenology, theory, and therapy. Memory 12, 403-415. doi: 10.1080/09658210444000025
    • (2004) Memory , vol.12 , pp. 403-415
    • Ehlers, A.1    Hackmann, A.2    Michael, T.3
  • 15
    • 60349127390 scopus 로고    scopus 로고
    • The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD)
    • doi: 10.1111/j.1755-5949.2008.00071.x
    • Fraser, G. A. (2009). The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD). CNS Neurosci. Ther. 15, 84-88. doi: 10.1111/j.1755-5949.2008.00071.x
    • (2009) CNS Neurosci. Ther , vol.15 , pp. 84-88
    • Fraser, G.A.1
  • 16
    • 70349084221 scopus 로고    scopus 로고
    • Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance
    • doi: 10.1523/JNEUROSCI.1223-09.2009
    • Ganon-Elazar, E., and Akirav, I. (2009). Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance. J. Neurosci. 29, 11078-11088. doi: 10.1523/JNEUROSCI.1223-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 11078-11088
    • Ganon-Elazar, E.1    Akirav, I.2
  • 17
    • 84856024507 scopus 로고    scopus 로고
    • Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress
    • doi: 10.1038/npp.2011.204
    • Ganon-Elazar, E., and Akirav, I. (2012). Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress. Neuropsychopharmacology 37, 456-466. doi: 10.1038/npp.2011.204
    • (2012) Neuropsychopharmacology , vol.37 , pp. 456-466
    • Ganon-Elazar, E.1    Akirav, I.2
  • 18
    • 84883653545 scopus 로고    scopus 로고
    • Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit
    • doi: 10.1016/j.psyneuen.2013.01.014. [Epub ahead of print]
    • Ganon-Elazar, E., and Akirav, I. (2013). Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit. Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2013.01.014. [Epub ahead of print].
    • (2013) Psychoneuroendocrinology
    • Ganon-Elazar, E.1    Akirav, I.2
  • 19
    • 0036431691 scopus 로고    scopus 로고
    • The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety
    • doi: 10.1046/j.1460-9568.2002.02192.x
    • Haller, J., Bakos, N., Szirmay, M., Ledent, C., and Freund, T. F. (2002). The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. Eur. J. Neurosci. 16, 1395-1398. doi: 10.1046/j.1460-9568.2002.02192.x
    • (2002) Eur. J. Neurosci , vol.16 , pp. 1395-1398
    • Haller, J.1    Bakos, N.2    Szirmay, M.3    Ledent, C.4    Freund, T.F.5
  • 20
    • 1842633508 scopus 로고    scopus 로고
    • Context-dependent effects of CB1 cannabinoid gene disruption on anxietylike and social behaviour in mice
    • doi: 10.1111/j.1460-9568.2004.03293.x
    • Haller, J., Varga, B., Ledent, C., Barna, I., and Freund, T. F. (2004). Context-dependent effects of CB1 cannabinoid gene disruption on anxietylike and social behaviour in mice. Eur. J. Neurosci. 19, 1906-1912. doi: 10.1111/j.1460-9568.2004.03293.x
    • (2004) Eur. J. Neurosci , vol.19 , pp. 1906-1912
    • Haller, J.1    Varga, B.2    Ledent, C.3    Barna, I.4    Freund, T.F.5
  • 21
    • 79958148855 scopus 로고    scopus 로고
    • Propofol enhances memory formation via an interaction with the endocannabinoid system
    • doi: 10.1097/ALN.0b013e31821c120e
    • Hauer, D., Ratano, P., Morena, M., Scaccianoce, S., Briegel, I., Palmery, M., et al. (2011). Propofol enhances memory formation via an interaction with the endocannabinoid system. Anesthesiology 114, 1380-1388. doi: 10.1097/ALN.0b013e31821c120e
    • (2011) Anesthesiology , vol.114 , pp. 1380-1388
    • Hauer, D.1    Ratano, P.2    Morena, M.3    Scaccianoce, S.4    Briegel, I.5    Palmery, M.6
  • 22
    • 84877149994 scopus 로고    scopus 로고
    • Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder
    • doi: 10.1371/journal.pone.0062741
    • Hauer, D., Schelling, G., Gola, H., Campolongo, P., Morath, J., Roozendaal, B., et al. (2013). Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder. PLoS ONE 8:e62741. doi: 10.1371/journal.pone.0062741
    • (2013) PLoS ONE , vol.8
    • Hauer, D.1    Schelling, G.2    Gola, H.3    Campolongo, P.4    Morath, J.5    Roozendaal, B.6
  • 23
    • 75849127602 scopus 로고    scopus 로고
    • The endocannabinoid system and the treatment of mood and anxiety disorders
    • doi: 10.2174/187152709789824624
    • Hill, M. N., and Gorzalka, B. B. (2009). The endocannabinoid system and the treatment of mood and anxiety disorders. CNS Neurol. Disord. Drug Targets 8, 451-458. doi: 10.2174/187152709789824624
    • (2009) CNS Neurol. Disord. Drug Targets , vol.8 , pp. 451-458
    • Hill, M.N.1    Gorzalka, B.B.2
  • 24
    • 38449115285 scopus 로고    scopus 로고
    • The endocannabinoid system and extinction learning
    • doi: 10.1007/s12035-007-8004-x
    • Lutz, B. (2007). The endocannabinoid system and extinction learning. Mol. Neurobiol. 36, 92-101. doi: 10.1007/s12035-007-8004-x
    • (2007) Mol. Neurobiol , vol.36 , pp. 92-101
    • Lutz, B.1
  • 25
    • 79952111552 scopus 로고    scopus 로고
    • Roles of the endocannabinoid system in learning and memory
    • doi: 10.1007/978-3-540-88955-7_8
    • Marsicano, G., and Lafenetre, P. (2009). Roles of the endocannabinoid system in learning and memory. Curr. Top. Behav. Neurosci. 1, 201-230. doi: 10.1007/978-3-540-88955-7_8
    • (2009) Curr. Top. Behav. Neurosci , vol.1 , pp. 201-230
    • Marsicano, G.1    Lafenetre, P.2
  • 26
    • 0036682222 scopus 로고    scopus 로고
    • The endogenous cannabinoid system controls extinction of aversive memories
    • doi: 10.1038/nature00839
    • Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., et al. (2002). The endogenous cannabinoid system controls extinction of aversive memories. Nature 418, 530-534. doi: 10.1038/nature00839
    • (2002) Nature , vol.418 , pp. 530-534
    • Marsicano, G.1    Wotjak, C.T.2    Azad, S.C.3    Bisogno, T.4    Rammes, G.5    Cascio, M.G.6
  • 27
    • 84857141169 scopus 로고    scopus 로고
    • Cannabinoids and anxiety
    • doi: 10.1007/7854_2009_16
    • Moreira, F. A., and Wotjak, C. T. (2010). Cannabinoids and anxiety. Curr. Top. Behav. Neurosci. 2, 429-450. doi: 10.1007/7854_2009_16
    • (2010) Curr. Top. Behav. Neurosci , vol.2 , pp. 429-450
    • Moreira, F.A.1    Wotjak, C.T.2
  • 28
    • 33846478897 scopus 로고    scopus 로고
    • Mechanisms of fear extinction
    • doi: 10.1038/sj.mp.4001939
    • Myers, K. M., and Davis, M. (2007). Mechanisms of fear extinction. Mol. Psychiatry 12, 120-150. doi: 10.1038/sj.mp.4001939
    • (2007) Mol. Psychiatry , vol.12 , pp. 120-150
    • Myers, K.M.1    Davis, M.2
  • 29
    • 84872929841 scopus 로고    scopus 로고
    • The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD
    • doi: 10.1002/da.22031
    • Neumeister, A. (2013). The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD. Depress. Anxiety 30, 93-96. doi: 10.1002/da.22031
    • (2013) Depress. Anxiety , vol.30 , pp. 93-96
    • Neumeister, A.1
  • 30
    • 84883158698 scopus 로고    scopus 로고
    • Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study
    • doi: 10.1038/mp. 2013.61
    • Neumeister, A., Normandin, M. D., Pietrzak, R. H., Piomelli, D., Zheng, M. Q., Gujarro-Anton, A., et al. (2013). Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol. Psychiatry 18, 1034-1040. doi: 10.1038/mp. 2013.61
    • (2013) Mol. Psychiatry , vol.18 , pp. 1034-1040
    • Neumeister, A.1    Normandin, M.D.2    Pietrzak, R.H.3    Piomelli, D.4    Zheng, M.Q.5    Gujarro-Anton, A.6
  • 31
    • 34548094300 scopus 로고    scopus 로고
    • Exposure to marijuana smoke impairs memory retrieval in mice
    • doi: 10.1124/jpet.107.119594
    • Niyuhire, F., Varvel, S. A., Martin, B. R., and Lichtman, A. H. (2007). Exposure to marijuana smoke impairs memory retrieval in mice. J. Pharmacol. Exp. Ther. 322, 1067-1075. doi: 10.1124/jpet.107.119594
    • (2007) J. Pharmacol. Exp. Ther , vol.322 , pp. 1067-1075
    • Niyuhire, F.1    Varvel, S.A.2    Martin, B.R.3    Lichtman, A.H.4
  • 32
    • 77953707182 scopus 로고    scopus 로고
    • The endocannabinoid system and psychiatric disorders
    • doi: 10.1016/j.expneurol.2010.03.018
    • Parolaro, D., Realini, N., Vigano, D., Guidali, C., and Rubino, T. (2010). The endocannabinoid system and psychiatric disorders. Exp. Neurol. 224, 3-14. doi: 10.1016/j.expneurol.2010.03.018
    • (2010) Exp. Neurol , vol.224 , pp. 3-14
    • Parolaro, D.1    Realini, N.2    Vigano, D.3    Guidali, C.4    Rubino, T.5
  • 33
    • 85027941560 scopus 로고    scopus 로고
    • Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence
    • doi: 10.1002/ dta.1377
    • Passie, T., Emrich, H. M., Karst, M., Brandt, S. D., and Halpern, J. H. (2012). Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence. Drug Test. Anal. 4, 649-659. doi: 10.1002/ dta.1377
    • (2012) Drug Test. Anal , vol.4 , pp. 649-659
    • Passie, T.1    Emrich, H.M.2    Karst, M.3    Brandt, S.D.4    Halpern, J.H.5
  • 34
    • 0024322451 scopus 로고
    • Post-traumatic stress disorder, hormones, and memory
    • doi: 10.1016/0006-3223(89)90033-4
    • Pitman, R. K. (1989). Post-traumatic stress disorder, hormones, and memory. Biol. Psychiatry 26, 221-223. doi: 10.1016/0006-3223(89)90033-4
    • (1989) Biol. Psychiatry , vol.26 , pp. 221-223
    • Pitman, R.K.1
  • 35
    • 79952311584 scopus 로고    scopus 로고
    • Posttraumatic stress and marijuana use coping motives: The mediating role of distress tolerance
    • doi: 10.1016/j.janxdis.2010.11.007
    • Potter, C. M., Vujanovic, A. A., Marshall-Berenz, E. C., Bernstein, A., and Bonn-Miller, M. O. (2011). Posttraumatic stress and marijuana use coping motives: the mediating role of distress tolerance. J. Anxiety Disord. 25, 437-443. doi: 10.1016/j.janxdis.2010.11.007
    • (2011) J. Anxiety Disord , vol.25 , pp. 437-443
    • Potter, C.M.1    Vujanovic, A.A.2    Marshall-Berenz, E.C.3    Bernstein, A.4    Bonn-Miller, M.O.5
  • 36
    • 84866361855 scopus 로고    scopus 로고
    • Cannabinoid facilitation of fear extinction memory recall in humans
    • doi: 10.1016/j.neuropharm.2012. 06.063
    • Rabinak, C. A., Angstadt, M., Sripada, C. S., Abelson, J. L., Liberzon, I., Milad, M. R., et al. (2013). Cannabinoid facilitation of fear extinction memory recall in humans. Neuropharmacology 64, 396-402. doi: 10.1016/j.neuropharm.2012. 06.063
    • (2013) Neuropharmacology , vol.64 , pp. 396-402
    • Rabinak, C.A.1    Angstadt, M.2    Sripada, C.S.3    Abelson, J.L.4    Liberzon, I.5    Milad, M.R.6
  • 38
    • 0030849620 scopus 로고    scopus 로고
    • Traumatic intrusive imagery as an emotional memory phenomenon: A review of research and explanatory information processing theories
    • doi: 10.1016/S0272-7358(97) 00025-1
    • vanOyen Witvliet, C. (1997). Traumatic intrusive imagery as an emotional memory phenomenon: a review of research and explanatory information processing theories. Clin. Psychol Rev. 17, 509-536. doi: 10.1016/S0272-7358(97) 00025-1
    • (1997) Clin. Psychol Rev , vol.17 , pp. 509-536
    • vanOyen, W.C.1


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