R Is for arginine: Metabolism of arginine takes off again, in new directions

Circulation

Volumn 128, Issue 13, 2013, Pages 1400-1404

  Michel, Thomas ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CITRULLINE; CREATINE; HOMOARGININE; N(G) METHYLARGININE; N(G),N(G) DIMETHYLARGININE;

AMINO ACID METABOLISM; CEREBROVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; CORONARY ARTERY DISEASE; DIABETES MELLITUS; HUMAN; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

AMINO ACIDS; ARGININE; EDITORIALS; NITRIC OXIDE; STROKE;

AMIDINOTRANSFERASES; ANIMALS; ARGININE; FEMALE; HOMOARGININE; HUMANS; MALE; STROKE;

EID: 84884665423     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.005924     Document Type: Review

References (20)

1. Marletta MA. Nitric oxide: biosynthesis and biological significance. Trends Biochem Sci. 1989;14:488-492.
2. Böger RH, Bode-Böger SM. The clinical pharmacology of l-arginine. Annu Rev Pharmacol Toxicol. 2001;41:79-99.
3. Vallance P, Leiper J. Cardiovascular biology of the asymmetric dimethyl arginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol. 2004;24:1023-1030.
4. Caplin B, Leiper J. Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators? Arterioscler Thromb Vasc Biol. 2012;32:1343-1353.
5. Morris SM Jr. Arginine metabolism in vascular biology and disease. Vasc Med. 2005;10(suppl 1):S83-S87.
6. Cardounel AJ, Cui H, Samouilov A, Johnson W, Kearns P, Tsai AL, Berka V, Zweier JL. Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function. J Biol Chem. 2007;282:879-887.
7. Bedford MT. Arginine methylation at a glance. J Cell Sci. 2007;120(pt 24):4243-4246.
8. Choe C, Atzler D, Wild PS, Carter AM, Boger RH, Ojeda F, Simova O, Stockbrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, Lüneburg N, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E. Homoarginine levels are regulated by l-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies. Circulation. 2013;128:1451-1461.
9. Wilson AM, Harada R, Nair N, Balasubramanian N, Cooke JP. l-Arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation. 2007;116:188-195.
10. van der Zwan LP, Davids M, Scheffer PG, Dekker JM, Stehouwer CD, Teerlink T. l-Homoarginine and l-arginine are antagonistically related to blood pressure in an elderly population: the Hoorn study. J Hypertens. 2013;31:1114-1123.
11. März W, Meinitzer A, Drechsler C, Pilz S, Krane V, Kleber ME, Fischer J, Winkelmann BR, Böhm BO, Ritz E, Wanner C. Homoarginine, cardiovascular risk, and mortality. Circulation. 2010;122:967-975.
12. Dreschler C, Kollerits B, Meinitzer A, Marz W, Ritz E, Konig P, Neyer U, Pilz S, Wanner C, Kronenberg F; MMKD Study Group. Homoarginine and progression of chronic kidney disease: results from the Mild to Moderate Kidney Disease Study. PLoS One. 2013; 8:e63560.
13. Schini VB, Vanhoutte PM. l-arginine evokes both endothelium-dependent and-independent relaxations in l-arginine-depleted aortas of the rat. Circ Res. 1991;68:209-216.
14. Moali C, Boucher J-L, Sari M-A, Steuhr DJ, Mansuy D. Substrate specificity of NO synthases: detailed comparison of l-arginine, homo-l-arginine, their N?-hydroxy derivatives, and N?-hydroxynor-l-rginine. Biochemistry. 1998;37:10453-10460.
15. Davids M, Ndika JD, Salomons GS, Blom HJ, Teerlink T. Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine. FEBS Lett. 2012;586:3653-3657.
16. Dumont J, Meroufel D, Bauters C, Hansmannel F, Bensemain F, Cottel D, Hamon M, Lambert JC, Ducimetière P, Amouyel P, Zureik M, Brousseau T. Association of ornithine transcarbamylase gene polymorphisms with hypertension and coronary artery vasomotion. Am J Hypertens. 2009;22:993-1000.
17. Wang Z, Nicholls SJ, Rodriguez ER, Kummu O, Hörkkö S, Barnard J, Reynolds WF, Topol EJ, DiDonato JA, Hazen SL. Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med. 2007;13:1176-1184.
18. Stockebrand M, Sauter K, Neu A, Isbrandt D, Choe CU. Differential regulation of AMPK activation in leptin-and creatine-deficient mice. FASEB J. June 28, 2013. http://www.fasebj.org/content/early/2013/06/28/fj.12-225136.long. doi:10.1096/fj.12-225136.
19. Jahangir E, Vita JA, Handy D, Holbrook M, Palmisano J, Beal R, Loscalzo J, Eberhardt RT. The effect of l-arginine and creatine on vascular function and homocysteine metabolism. Vasc Med. 2009;14:239-248.
20. Cullen ME, Yuen AHY, Felkin LE, Smolenski RT, Hall JL, Grindle S, Miller LW, Birks EJ, Yacoub MH, Barton PJR. Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery; potential implications for local creatine synthesis. Circulation. 2006;114(suppl I):I-16-I-20.