Simultaneous determination of seven ginsenosides in du Shen Tang decoction by rapid resolution liquid chromatography (RRLC) coupled with tandem mass spectrometry

Food Chemistry

Volumn 141, Issue 4, 2013, Pages 4046-4050

  Guo, Na ^a   Ablajan, Keyume ^b   Fan, Bin ^a   Yan, Han ^a   Yu, Youhua ^a   Dou, Deqiang ^c  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b XINJIANG UNIVERSITY   (China)

^c LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Du Shen Tang decoction; Ginsenosides; Rapid resolution liquid chromatography; Tandem mass spectrometry

Indexed keywords

CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PHARMACODYNAMICS; SPECTROMETRY;

ANALYTES; DU SHEN TANG DECOCTION; GINSENOSIDE RE; GINSENOSIDES; PANAX GINSENG; RAPID RESOLUTION LIQUID CHROMATOGRAPHIES; SIMULTANEOUS DETERMINATIONS; TANDEM MASS SPECTROMETRY;

DRUG PRODUCTS;

DU SHEN TANG DECOCTION; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 1; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GINSENG; MEASUREMENT REPEATABILITY; TANDEM MASS SPECTROMETRY; TIME; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

PANAX GINSENG;

DU SHEN TANG DECOCTION; GINSENOSIDES; RAPID RESOLUTION LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; GINSENOSIDES; MOLECULAR STRUCTURE; PANAX; TANDEM MASS SPECTROMETRY;

EID: 84884604871     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.06.117     Document Type: Article

References (28)

1. Ackloo, S. Z., Smith, R. W., Terlouw, J. K., & McCarry, B. E. (2000). Characterization of ginseng saponins using electrospray mass spectrometry and collision induced dissociation experiments of metal attachment ions. Analyst, 125, 591-597. (Pubitemid 30223643)
2. Akerele, O. (1992). WHO guidelines for the assessment of herbal medicines. Fitoterapia, 63, 99-104.
3. Chu, S. F., & Zhang, J. T. (2009). New achievements in ginseng research and its future prospects. Chinese Journal of Integrative Medicine, 15, 403-408.
4. Fuzzati, N. (2004). Analysis methods of ginsenosides. Journal of Chromatography B, 812, 119-133. (Pubitemid 39535405)
5. Guillarme, D., Grata, E., Glauser, G., Wolfender, J., Veuthey, J., & Rudaz, S. (2009). Some solutions to obtain very efficient separations in isocratic and gradient modes using small particles size and ultra-high pressure. Journal of Chromatography A, 1216, 3232-3243.
6. Hu, P., Luo, G. A., Wang, Q., Zhao, Z. Z., Wang, W., & Jiang, Z. H. (2009). The retention behavior of ginsenosides in HPLC and its application to quality assessment of radix ginseng. Archives of Pharmacal Research, 32, 667-676.
7. Jang, D. J., Lee, M. S., Shin, B. C., Lee, Y. C., & Ernst, E. (2008). Red ginseng for treating erectile dysfunction: A systematic review. British Journal of Clinical Pharmacology, 66, 444-450.
8. Jia, L., & Zhao, Y. (2009). Current evaluation of the millennium phytomedicine- Ginseng (I): Etymology, pharmacognosy, phytochemistry, market and regulations. Current Medicinal Chemistry, 16, 2475-2484.
9. Jia, L., Zhao, Y., & Liang, X. J. (2009). Current evaluation of the millennium phytomedicine-Ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Current Medicinal Chemistry, 16, 2924-2942.
10. Lai, C. M., Li, S. P., Yu, H., Wan, J. B., Kan, K. W., & Wang, Y. T. (2006). A rapid HPLC-ESI-MS/MS for qualitative and quantitative analysis of saponins in "XUESETONG" injection. Journal of Pharmaceutical and Biomedical Analysis, 40, 669-678. (Pubitemid 43227391)
11. Leung, K. W., & Wong, A. S. (2010). Pharmacology of ginsenosides: A literature review. Chinese Medicine, 5, 1-7.
12. Li, S. L., Lai, S. F., Song, J. Z., Qiao, C. F., Liu, X., Zhou, Y., et al. (2010). Decoctinginduced chemical transformations and global quality of Du-Shen-Tang, the decoction of ginseng evaluated by UPLC-Q-TOF-MS/MS based chemical profiling approach. Journal of Pharmaceutical and Biomedical Analysis, 53, 946-957.
13. Li, L., Luo, G. A., Liang, Q. L., Hu, P., & Wang, Y. M. (2010). Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS. Journal of Pharmaceutical and Biomedical Analysis, 52, 66-72.
14. Liu, B. C. (2005). Two cases treatment of cardiogenic shock by Du-Shen-Tang. Journal Practical Clinical Combined Traditional Chinese and Western Medicine, 5, 57-60.
15. Liu, Y., Yang, J. S., & Cai, Z. W. (2006). Chemical investigation on sijunzi decoction and its two major herbs Panax ginseng and Glycyrrhiza uralensis by LC/MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 41, 1642-1647. (Pubitemid 44247462)
16. Lu, J. M., Yao, Q., & Chen, C. (2009). Ginseng compounds: An update on their molecular mechanisms and medical applications. Current Vascular Pharmacology, 7, 293-302.
17. Luo, J. Z., & Luo, L. (2009). Ginseng on hyperglycemia: Effects and mechanisms. Evidence-based Complementary and Alternative Medicine, 6, 423-427.
18. Park, C. S., Yoo, M. H., Noh, K. H., & Oh, D. K. (2010). Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases. Applied Microbiology and Biotechnology, 87, 9-19.
19. Popovich, D. G., Hu, C., Durance, T. D., & Kitts, D. D. (2005). Retention of ginsenosides in dried ginseng root: Comparison of drying methods. Journal of Food Science, 70, 355-358.
20. Qi, L. W., Wang, C. Z., & Yuan, C. S. (2011). Isolation and analysis of ginseng: Advances and challenges. Natural Product Report, 28, 467-495.
21. Qi, L. W., Wang, H. Y., Zhang, H., Wang, C. Z., Li, P., & Yuan, C. S. (2012). Diagnostic ion filtering to characterize ginseng saponins by rapid liquid chromatography with time-of-flight mass spectrometry. Journal of Chromatography A, 1230, 93-99.
22. Shangguan, D. H., Han, H. W., Zhao, R., Zhao, Y. X., Xiong, S. X., & Liu, G. Q. (2001). New method for high-performance liquid chromatographic separation and fluorescence detection of ginsenosides. Journal of Chromatography A, 910, 367-372. (Pubitemid 32126303)
23. Song, F. G., Liu, Z. Q., Liu, S. Y., & Cai, Z. G. (2005). Differentiation and identification of ginsenoside isomers by electrospray ionization tandem mass spectrometry. Analytica Chimica Acta, 531, 69-77.
24. Toh, D. F., New, L. S., Koh, H. L., & Chan, E. C. (2010). Ultra-high performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOFMS) for timedependent profiling of raw and steamed Panax notoginseng. Journal of Pharmaceutical and Biomedical Analysis, 52, 43-50.
25. Wan, J. B., Lai, C. M., Lai, S. P., Lee, M. Y., Kong, L. Y., & Wang, Y. T. (2006). Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction. Journal of Pharmaceutical and Biomedical Analysis, 41, 274-279.
26. Wang, Y., Yang, L., He, Y. Q., Wang, C. H., Welbeck, E. W., Bligh, S. W. A., et al. (2008). Characterization of fifty-one flavonoids in a Chinese herbal prescription longdan xiegan decoction by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry and photodiode array detection. Rapid Communication in Mass Spectrometry, 22, 1767-1778. (Pubitemid 351947741)
27. Xie, G. X., Plumb, R., Su, M. M., Xu, Z. H., Zhao, A. H., Qiu, M. F., et al. (2008). Ultraperformance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research. Journal of Separation Science, 31, 1015-1026. (Pubitemid 351649827)
28. Zhen, Y. X., & Yang, B. Y. (2002). Application of Du-Shen-Tang in obsterics. Chengdu Medicine, 28, 215-216.