-
1
-
-
79957889347
-
The productivity crisis in pharmaceutical R&D
-
F. Pammolli The productivity crisis in pharmaceutical R&D Nat. Rev. Drug Discov. 10 2011 428 438
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 428-438
-
-
Pammolli, F.1
-
2
-
-
78049467253
-
The importance of new companies for drug discovery: Origins of a decade of new drugs
-
R. Kneller The importance of new companies for drug discovery: origins of a decade of new drugs Nat. Rev. Drug Discov. 9 2010 867 882
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 867-882
-
-
Kneller, R.1
-
3
-
-
79851477450
-
The role of public-sector research in the discovery of drugs and vaccines
-
A.J. Stevens The role of public-sector research in the discovery of drugs and vaccines N. Engl. J. Med. 364 2011 535 541
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 535-541
-
-
Stevens, A.J.1
-
4
-
-
84869486398
-
Challenges for academic drug discovery
-
W.L. Jorgensen Challenges for academic drug discovery Angew. Chem. Int. Ed. Engl. 51 2012 11680 11684
-
(2012)
Angew. Chem. Int. Ed. Engl.
, vol.51
, pp. 11680-11684
-
-
Jorgensen, W.L.1
-
5
-
-
77956796338
-
Drug discovery in academia: The third way?
-
J. Frearson, and P. Wyatt Drug discovery in academia: the third way? Expert Opin. Drug Discov. 5 2010 909 919
-
(2010)
Expert Opin. Drug Discov.
, vol.5
, pp. 909-919
-
-
Frearson, J.1
Wyatt, P.2
-
6
-
-
84858263542
-
Drug discovery 2012 and beyond
-
D.P. Rotella Drug discovery 2012 and beyond ACS Med. Chem. Lett. 3 2012 172 173
-
(2012)
ACS Med. Chem. Lett.
, vol.3
, pp. 172-173
-
-
Rotella, D.P.1
-
7
-
-
84875178774
-
Drug discovery in an academic setting: Playing to the strengths
-
D.M. Huryn Drug discovery in an academic setting: playing to the strengths ACS Med. Chem. Lett. 4 2013 313 315
-
(2013)
ACS Med. Chem. Lett.
, vol.4
, pp. 313-315
-
-
Huryn, D.M.1
-
8
-
-
3042575322
-
Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent
-
DOI 10.1158/1078-0432.CCR-040010
-
A.A. Adjei Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent Clin. Cancer Res. 10 2004 4276S 4280S (Pubitemid 38812462)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.12
-
-
Adjei, A.A.1
-
9
-
-
84885389825
-
Acyclonucleosides to Ziagen: A journey
-
R. Vince Acyclonucleosides to Ziagen: a journey Abstr. Pap. Am. Chem. Soc. 2011 242
-
(2011)
Abstr. Pap. Am. Chem. Soc.
, pp. 242
-
-
Vince, R.1
-
10
-
-
70449707741
-
Fospropofol: A new sedative-hypnotic agent for monitored anesthesia care
-
G.D. Moore Fospropofol: a new sedative-hypnotic agent for monitored anesthesia care Ann. Pharmacother. 43 2009 1802 1808
-
(2009)
Ann. Pharmacother.
, vol.43
, pp. 1802-1808
-
-
Moore, G.D.1
-
11
-
-
84884595043
-
National Cancer Institute's Chemical Biology Consortium: An academic/public partnership for the discovery of novel cancer therapeutics
-
368-ORGN
-
J.H. Doroshow National Cancer Institute's Chemical Biology Consortium: an academic/public partnership for the discovery of novel cancer therapeutics Abstr. Pap. Am. Chem. Soc. 238 2009 368-ORGN
-
(2009)
Abstr. Pap. Am. Chem. Soc.
, vol.238
-
-
Doroshow, J.H.1
-
12
-
-
79957898111
-
US academic drug discovery
-
S. Frye US academic drug discovery Nat. Rev. Drug Discov. 10 2011 409 410
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 409-410
-
-
Frye, S.1
-
13
-
-
84864116400
-
The role of academic institutions in the development of drugs for rare and neglected diseases
-
L.D. Coles, and J.C. Cloyd The role of academic institutions in the development of drugs for rare and neglected diseases Clin. Pharmacol. Ther. 92 2012 193 202
-
(2012)
Clin. Pharmacol. Ther.
, vol.92
, pp. 193-202
-
-
Coles, L.D.1
Cloyd, J.C.2
-
14
-
-
84884597132
-
Academia increasingly going beyond basic research by setting up translational med centers
-
MAY
-
A. Philippidis Academia increasingly going beyond basic research by setting up translational med centers Genet. Eng. Biotechnol. News 30 May 2012
-
(2012)
Genet. Eng. Biotechnol. News
, vol.30
-
-
Philippidis, A.1
-
15
-
-
84858328109
-
New institute aims to help academics make medicines
-
erratum 336, 541
-
R.F. Service New institute aims to help academics make medicines Science 335 2012 1288 1289 erratum 336, 541
-
(2012)
Science
, vol.335
, pp. 1288-1289
-
-
Service, R.F.1
-
16
-
-
84866739808
-
Drug discovery in pharmaceutical industry: Productivity challenges and trends
-
I. Khanna Drug discovery in pharmaceutical industry: productivity challenges and trends Drug Discov. Today 17 2012 1088 1102
-
(2012)
Drug Discov. Today
, vol.17
, pp. 1088-1102
-
-
Khanna, I.1
-
17
-
-
78650661679
-
Advancing translational research collaborations
-
L.M. Portilla Advancing translational research collaborations Sci. Transl. Med. 2 2010 63cm30
-
(2010)
Sci. Transl. Med.
, vol.2
-
-
Portilla, L.M.1
-
18
-
-
84862809512
-
Collaborative approaches to anticancer drug discovery and development: A Cancer Research UK perspective
-
R.J. Williams Collaborative approaches to anticancer drug discovery and development: a Cancer Research UK perspective Drug Discov. Today 17 2012 185 187
-
(2012)
Drug Discov. Today
, vol.17
, pp. 185-187
-
-
Williams, R.J.1
-
19
-
-
84875166951
-
European lead factory opens for business
-
A. Mullard European lead factory opens for business Nat. Rev. Drug Discov. 12 2013 173 175
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 173-175
-
-
Mullard, A.1
-
20
-
-
33748286712
-
Why academic drug discovery makes sense [2]
-
A.P. Kozikowski Why academic drug discovery makes sense Science 313 2006 1235 1236 (Pubitemid 44330930)
-
(2006)
Science
, vol.313
, Issue.5791
, pp. 1235-1236
-
-
Kozikowski, A.P.1
Roth, B.2
Tropsha, A.3
-
21
-
-
45149104960
-
Translational research: Crossing the valley of death
-
DOI 10.1038/453840a, PII 453840A
-
D. Butler Translational research: crossing the valley of death Nature 453 2008 840 842 (Pubitemid 351832542)
-
(2008)
Nature
, vol.453
, Issue.7197
, pp. 840-842
-
-
Butler, D.1
-
22
-
-
77953920789
-
Traversing the valley of death: A guide to assessing prospects for translational success
-
B.S. Coller, and R.M. Califf Traversing the valley of death: a guide to assessing prospects for translational success Sci. Transl. Med. 1 2009 10cm9
-
(2009)
Sci. Transl. Med.
, vol.1
-
-
Coller, B.S.1
Califf, R.M.2
-
23
-
-
84859438323
-
The valley of death in anticancer drug development: A reassessment
-
D.J. Adams The valley of death in anticancer drug development: a reassessment Trends Pharmacol. Sci. 33 2012 173 180
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 173-180
-
-
Adams, D.J.1
-
24
-
-
77955915185
-
Strategies at the interface of drug discovery and development: Early optimization of the solid state phase and preclinical toxicology formulation for potential drug candidates
-
M. Palucki Strategies at the interface of drug discovery and development: early optimization of the solid state phase and preclinical toxicology formulation for potential drug candidates J. Med. Chem. 53 2010 5897 5905
-
(2010)
J. Med. Chem.
, vol.53
, pp. 5897-5905
-
-
Palucki, M.1
-
25
-
-
33847295225
-
Designing a molecular delivery system within a preclinical timeframe
-
J.O. Henck, and S.R. Byrn Designing a molecular delivery system within a preclinical timeframe Drug Discov. Today 12 2007 189 199
-
(2007)
Drug Discov. Today
, vol.12
, pp. 189-199
-
-
Henck, J.O.1
Byrn, S.R.2
-
26
-
-
77956374119
-
Accelerating proof of concept for small molecule drugs using solid-state chemistry
-
S.R. Byrn Accelerating proof of concept for small molecule drugs using solid-state chemistry J. Pharm. Sci. 99 2010 3665 3675
-
(2010)
J. Pharm. Sci.
, vol.99
, pp. 3665-3675
-
-
Byrn, S.R.1
-
27
-
-
53049093590
-
The emerging utility of co-crystals in drug discovery and development
-
J.E. Macor, Elsevier Academic Press, Inc
-
N.A. Meanwell The emerging utility of co-crystals in drug discovery and development J.E. Macor, Annual Reports in Medicinal Chemistry vol. 43 2008 Elsevier Academic Press, Inc 373 404
-
(2008)
Annual Reports in Medicinal Chemistry
, vol.43
, pp. 373-404
-
-
Meanwell, N.A.1
-
28
-
-
84885387842
-
Minnelide: A novel therapeutic strategy against pancreatic cancer
-
R. Chugh Minnelide: a novel therapeutic strategy against pancreatic cancer Pancreas 38 2009 989
-
(2009)
Pancreas
, vol.38
, pp. 989
-
-
Chugh, R.1
-
29
-
-
84885380641
-
Minnelide: Single chemotherapeutic agent against pancreatic cancer
-
R. Chugh Minnelide: single chemotherapeutic agent against pancreatic cancer Pancreas 39 2010 1314 1315
-
(2010)
Pancreas
, vol.39
, pp. 1314-1315
-
-
Chugh, R.1
-
30
-
-
84867793735
-
A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer
-
R. Chugh A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer Sci. Transl. Med. 4 2012 156ra139
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Chugh, R.1
-
32
-
-
60749099362
-
Dendrimers as versatile platform in drug delivery applications
-
S. Svenson Dendrimers as versatile platform in drug delivery applications Eur. J. Pharm. Biopharm. 71 2009 445 462
-
(2009)
Eur. J. Pharm. Biopharm.
, vol.71
, pp. 445-462
-
-
Svenson, S.1
-
33
-
-
70350576352
-
Lilly's chorus experiment
-
R. Longman Lilly's chorus experiment In Vivo: Bus. Med. Rep. 25 2007 1 5
-
(2007)
Vivo: Bus. Med. Rep.
, vol.25
, pp. 1-5
-
-
Longman, R.1
-
34
-
-
77956384896
-
A solid-state approach to enable early development compounds: Selection and animal bioavailability studies of an itraconazole amorphous solid dispersion
-
D. Engers A solid-state approach to enable early development compounds: selection and animal bioavailability studies of an itraconazole amorphous solid dispersion J. Pharm. Sci. 99 2010 3901 3922
-
(2010)
J. Pharm. Sci.
, vol.99
, pp. 3901-3922
-
-
Engers, D.1
|