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Pasquini MC, Wang Z. Current uses and outcomes of hematopoietic stem cell transplantation 2012. Summary slides. CIBMTR. 2012. Available via http://www.cibmtr.org/referencecenter/slidesreports/summaryslides/pages/index. aspx.
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Summary Slides. CIBMTR
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Pasquini, M.C.1
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Acute myeloid leukemia in first remission: To choose transplantation or not?
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23439752 10.1200/JCO.2012.43.4258 This is an excellent review of the evidence for and against HSCT in CR1 AML. Relapse risk is discussed in the context of cytogenetic and genetic mutation, with a suggested patient selection algorithm
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• Stone RM. Acute myeloid leukemia in first remission: to choose transplantation or not? J Clin Oncol. 2013;31(10):1262-6. This is an excellent review of the evidence for and against HSCT in CR1 AML. Relapse risk is discussed in the context of cytogenetic and genetic mutation, with a suggested patient selection algorithm.
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Stone, R.M.1
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Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: Systematic review and meta-analysis of prospective clinical trials
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19509382 10.1001/jama.2009.813 1:CAS:528:DC%2BD1MXntFCms7o%3D
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Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories
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22564995 10.1200/JCO.2011.39.6499 This is a large European registry analysis outlining the very poor prognosis of AML with monosomal karyotype. Data supporting a modest benefit for HSCT are given
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• Cornelissen JJ, Breems D, van Putten WL, Gratwohl AA, Passweg JR, Pabst T, et al. Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories. J Clin Oncol. 2012;30(17):2140-6. This is a large European registry analysis outlining the very poor prognosis of AML with monosomal karyotype. Data supporting a modest benefit for HSCT are given.
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22096250 10.1182/blood-2011-07-367508 1:CAS:528:DC%2BC38XhsVKlt7k%3D
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Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia
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Mohr B, Schetelig J, Schafer-Eckart K, Schmitz N, Hanel M, Rosler W, et al. Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia. Br J Haematol. 2013;161(2):237-44.
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22855604 10.1182/blood-2012-03-417972 1:CAS:528:DC%2BC38XhsVKiu7rP Similarly to other oncologic diagnoses, abnl(17p) confers one of the worst cytogenetic risks known. In light of these data, such patients are in need of novel therapeutic strategies
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• Middeke JM, Beelen D, Stadler M, Gohring G, Schlegelberger B, Baurmann H, et al. Outcome of high-risk acute myeloid leukemia after allogeneic hematopoietic cell transplantation: negative impact of abnl(17p) and -5/5q. Blood. 2012;120(12):2521-8. Similarly to other oncologic diagnoses, abnl(17p) confers one of the worst cytogenetic risks known. In light of these data, such patients are in need of novel therapeutic strategies.
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Middeke, J.M.1
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Classifying cytogenetics in patients with acute myelogenous leukemia in complete remission undergoing allogeneic transplantation: A Center for International Blood and Marrow Transplant Research study
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21810400 10.1016/j.bbmt.2011.07.024 This large registry review by the CIBMTR aims to validate existing cytogenetic risk classification and proposes a new HSCT-specific cytogenic risk model
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• Armand P, Kim HT, Zhang MJ, Perez WS, Dal Cin PS, Klumpp TR, et al. Classifying cytogenetics in patients with acute myelogenous leukemia in complete remission undergoing allogeneic transplantation: a Center for International Blood and Marrow Transplant Research study. Biol Blood Marrow Transplant. 2012;18(2):280-8. This large registry review by the CIBMTR aims to validate existing cytogenetic risk classification and proposes a new HSCT-specific cytogenic risk model.
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Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): A Cancer and Leukemia Group B study
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Paschka P, Marcucci G, Ruppert AS, Mrozek K, Chen H, Kittles RA, et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B study. J Clin Oncol. 2006;24(24):3904-11.
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23385613 10.1097/MOH.0b013e32835dd84a 1:CAS:528:DC%2BC3sXit1egsbo%3D
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Genetic profiling in acute myeloid leukaemia where are we and what is its role in patient management
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23240632 10.1111/bjh.12135 1:CAS:528:DC%2BC3sXht1Chu7o%3D This excellent review is recommended for the reader seeking a more in depth introduction to the prognostic and predictive roles of genetic profiling in AML
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• Ofran Y, Rowe JM. Genetic profiling in acute myeloid leukaemia where are we and what is its role in patient management. Br J Haematol. 2013;160(3):303-20. This excellent review is recommended for the reader seeking a more in depth introduction to the prognostic and predictive roles of genetic profiling in AML.
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Ofran, Y.1
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Brunet S, Labopin M, Esteve J, Cornelissen J, Socie G, Iori AP, et al. Impact of FLT3 internal tandem duplication on the outcome of related and unrelated hematopoietic transplantation for adult acute myeloid leukemia in first remission: a retrospective analysis. J Clin Oncol. 2012;30(7):735-41.
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22659680 10.1038/bmt.2012.88 1:STN:280:DC%2BC38nosVaqtw%3D%3D
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Sengsayadeth SM, Jagasia M, Engelhardt BG, Kassim A, Strickland SA, Goodman S, et al. Allo-SCT for high-risk AML-CR1 in the molecular era: impact of FLT3/ITD outweighs the conventional markers. Bone Marrow Transplant. 2012;47(12):1535-7.
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Sengsayadeth, S.M.1
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Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
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18450602 10.1056/NEJMoa074306 1:CAS:528:DC%2BD1cXlt1Ggu70%3D
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Hematopoietic transplantation for acute myeloid leukemia with internal tandem duplication of FLT3 gene (FLT3/ITD)
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23385863 10.1097/CCO.0b013e32835ec91f 1:CAS:528:DC%2BC3sXit1Ghsbc%3D This is an in-depth focused review on the current role of HSCT in treating FLT3-ITD mutation AML
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• Brunet S, Martino R, Sierra J. Hematopoietic transplantation for acute myeloid leukemia with internal tandem duplication of FLT3 gene (FLT3/ITD). Curr Opin Oncol. 2013;25(2):195-204. This is an in-depth focused review on the current role of HSCT in treating FLT3-ITD mutation AML.
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Brunet, S.1
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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
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22417203 10.1056/NEJMoa1112304 1:CAS:528:DC%2BC38XktlCqtLs%3D Using a panel of 18 genes, the investigators identified somatic alterations in 97% of AML patients. This study demonstrates co-occurrence of mutations and their effect on outcomes in various cytogenetic risk groups. The role of IDH1/IDH2 mutations in the context of NPM1 is reported as are the response of patients with DNMT3A to high-dose daunorubicin
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• Patel JP, Gonen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366(12):1079-89. Using a panel of 18 genes, the investigators identified somatic alterations in 97% of AML patients. This study demonstrates co-occurrence of mutations and their effect on outcomes in various cytogenetic risk groups. The role of IDH1/IDH2 mutations in the context of NPM1 is reported as are the response of patients with DNMT3A to high-dose daunorubicin.
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Impact of pretransplantation minimal residual disease, as detected by multiparametric flow cytometry, on outcome of myeloablative hematopoietic cell transplantation for acute myeloid leukemia
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Walter RB, Gooley TA, Wood BL, Milano F, Fang M, Sorror ML, et al. Impact of pretransplantation minimal residual disease, as detected by multiparametric flow cytometry, on outcome of myeloablative hematopoietic cell transplantation for acute myeloid leukemia. J Clin Oncol. 2011;29(9):1190-7.
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Persistence of cytogenetic abnormalities at complete remission after induction in patients with acute myeloid leukemia: Prognostic significance and the potential role of allogeneic stem-cell transplantation
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25
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Significance of persistent cytogenetic abnormalities on myeloablative allogeneic stem cell transplantation in first complete remission
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22982533 10.1016/j.bbmt.2012.09.002
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Quantitative monitoring of WT1 expression in peripheral blood before and after allogeneic stem cell transplantation for acute myeloid leukemia - A useful tool for early detection of minimal residual disease
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23067220 10.4149/neo-2013-011 1:STN:280:DC%2BC3s%2FltlelsQ%3D%3D
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Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia
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22327226 10.1182/blood-2011-09-381699 1:CAS:528:DC%2BC38Xms1altro%3D This is a very large registry analysis showing equivalent outcomes between matched unrelated donor HSCT and matched related donor HSCT in AML
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• Saber W, Opie S, Rizzo JD, Zhang MJ, Horowitz MM, Schriber J. Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia. Blood. 2012;119(17):3908-16. This is a very large registry analysis showing equivalent outcomes between matched unrelated donor HSCT and matched related donor HSCT in AML.
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Brunstein CG, Fuchs EJ, Carter SL, Karanes C, Costa LJ, Wu J, et al. Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts. Blood. 2011;118(2):282-8.
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