Increased monocyte adhesion by endothelial expression of VCAM-1 missense variation invitro

Atherosclerosis

Volumn 230, Issue 2, 2013, Pages 185-190

  Schmitz, Boris ^a   Vischer, Peter ^b   Brand, Eva ^a   Schmidt Petersen, Klaus ^c   Korb Pap, Adelheid ^a   Guske, Katrin ^a   Nedele, Johanna ^a   Schelleckes, Michael ^a   Hillen, Jan ^a   Rötrige, Alois ^a   Simmet, Thomas ^c   Paul, Martin ^d   Cambien, François ^e   Brand, Stefan Martin ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e INSERM   (France)

Author keywords

Cardiovascular disease; Functional analyses; Missense variants; Monocyte adhesion; Vascular cell adhesion protein 1

Indexed keywords

GENOMIC DNA; MESSENGER RNA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CELLS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE LOCUS; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MISSENSE MUTATION; MONOCYTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE;

CARDIOVASCULAR DISEASE; FUNCTIONAL ANALYSES; MISSENSE VARIANTS; MONOCYTE ADHESION; VASCULAR CELL ADHESION PROTEIN-1;

ALLELES; ATHEROSCLEROSIS; BLOTTING, WESTERN; CELL ADHESION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INFLAMMATION; MONOCYTES; MUTATION; MUTATION, MISSENSE; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; U937 CELLS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84884578816     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.07.039     Document Type: Article

References (24)

1. Osborn L., Hession C., Tizard R., et al. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 1989, 59:1203-1211.
2. Cybulsky M.I., Fries J.W., Williams A.J., et al. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc Natl Acad Sci U S A 1991, 88:7859-7863.
3. Cybulsky M.I., Fries J.W., Williams A.J., et al. Alternative splicing of human VCAM-1 in activated vascular endothelium. Am J Pathol 1991, 138:815-820.
4. Carlos T.M., Harlan J.M. Leukocyte-endothelial adhesion molecules. Blood 1994, 84:2068-2101.
5. Elices M.J., Osborn L., Takada Y., et al. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 1990, 60:577-584.
6. Chan B.M., Elices M.J., Murphy E., Hemler M.E. Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. JBiol Chem 1992, 267:8366-8370.
7. Ockenhouse C.F., Tegoshi T., Maeno Y., et al. Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. JExp Med 1992, 176:1183-1189.
8. Dansky H.M., Barlow C.B., Lominska C., et al. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler Thromb Vasc Biol 2001, 21:1662-1667.
9. Cybulsky M.I., Iiyama K., Li H., et al. Amajor role for VCAM-1, but not ICAM-1, in early atherosclerosis. JClin Invest 2001, 107:1255-1262.
10. Taylor J.G., Tang D.C., Savage S.A., et al. Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. Blood 2002, 100:4303-4309.
11. Hoppe C., Klitz W., Cheng S., CSSCD Investigators, et al. Gene interactions and stroke risk in children with sickle cell anemia. Blood 2004, 103:2391-2396.
12. Parra H.J., Arveiler D., Evans A.E., et al. Acase-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease: the ECTIM Study. Arterioscler Thromb 1992, 12:701-707.
13. Kruglyak L., Nickerson D.A. Variation is the spice of life. Nat Genet 2001, 27:234-236.
14. Herrmann S.M., Funke-Kaiser H., Schmidt-Petersen K., et al. Characterization of the polymorphic structure of the cathepsin G gene: role in cardio- and cerebrovascular diseases. Arterioscler Thromb Vasc Biol 2001, 21:1538-1543.
15. Edgell C.J., McDonald C.C., Graham J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci U S A 1983, 80:3734-3737.
16. Wada Y., Otu H., Wu S., et al. Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell. FASEB J 2005, 19:1914-1916.
17. Hwa J.S., Mun L., Kim H.J., et al. Genipin selectively inhibits TNF-α-activated VCAM-1 but not ICAM-1 expression by upregulation of PPAR-γ in human endothelial cells. Korean J Physiol Pharmacol 2011, 15:157-162.
18. Harris T.A., Yamakuchi M., Ferlito M., Mendell J.T., Lowenstein C.J. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci U S A 2008, 105:1516-1521.
19. Hansson G.K. Inflammatory mechanisms in atherosclerosis. JThromb Haemost 2009, (Suppl.1):328-331.
20. Barthel S.R., Annis D.S., Mosher D.F., Johansson M.W. Differential engagement of modules 1 and 4 of vascular cell adhesion molecule-1 (CD106) by integrins alpha4beta1 (CD49d/29) and alphaMbeta2 (CD11b/18) of eosinophils. JBiol Chem 2006, 281:32175-32187.
21. Barthel S.R., Johansson M.W., McNamee D.M., Mosher D.F. Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma. JLeukoc Biol 2008, 83:1-12.
22. Johnson A.D., Zhang Y., Papp A.C., et al. Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. Pharmacogenet Genomics 2008, 18:781-791.
23. Montes-Sánchez D., Ventura J.L., Mitre I., et al. Glycosylated VCAM-1 isoforms revealed in 2D western blots of HUVECs treated with tumoral soluble factors of breast cancer cells. BMC Chem Biol 2009, 9:7.
24. Cybulsky M.I., Gimbrone M.A. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991, 251:788-791.