Delayed Wound Repair in Sepsis Is Associated with Reduced Local Pro-Inflammatory Cytokine Expression

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Sommer, Katharina ^a   Sander, Anna Lena ^a   Albig, Michael ^a   Weber, Roxane ^a   Henrich, Dirk ^a   Frank, Johannes ^a   Marzi, Ingo ^a   Jakob, Heike ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; MATRILYSIN; MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; EPITHELIZATION; FEMALE; HOSPITAL PATIENT; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIGATION; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PUNCTURE; SEPSIS; WOUND CLOSURE; WOUND HEALING IMPAIRMENT;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMATION MEDIATORS; MATRIX METALLOPROTEINASES; MICE; MICE, HAIRLESS; SEPSIS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; WOUND HEALING;

EID: 84884566765     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073992     Document Type: Article

References (25)

1. Martin GS, Mannino DM, Eaton S, Moss M, (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348: 1546-1554.
2. Barriere SL, Lowry SF, (1995) An overview of mortality risk prediction in sepsis. Crit Care Med 23: 376-393.
3. Koskela M, Gaddnas F, Ala-Kokko TI, Laurila JJ, Saarnio J, et al. (2009) Epidermal wound healing in severe sepsis and septic shock in humans. Crit Care 13: R100.
4. Rico RM, Ripamonti R, Burns AL, Gamelli RL, DiPietro LA, (2002) The effect of sepsis on wound healing. J Surg Res 102: 193-197.
5. Santoro MM, Gaudino G, (2005) Cellular and molecular facets of keratinocyte reepithelization during wound healing. Exp Cell Res 304: 274-286.
6. Weinstein DA, Kirsner RS, (2010) Refractory ulcers: the role of tumor necrosis factor-alpha. J Am Acad Dermatol 63: 146-154.
7. Steenfos HH, (1994) Growth factors and wound healing. Scand J Plast Reconstr Surg Hand Surg 28: 95-105.
8. Rapala K, Laato M, Niinikoski J, Kujari H, Soder O, et al. (1991) Tumor necrosis factor alpha inhibits wound healing in the rat. Eur Surg Res 23: 261-268.
9. Gill SE, Parks WC, (2008) Metalloproteinases and their inhibitors: regulators of wound healing. Int J Biochem Cell Biol 40: 1334-1347.
10. Leask A, Abraham DJ, (2004) TGF-beta signaling and the fibrotic response. Faseb J 18: 816-827.
11. Mahdavian Delavary B, van der Veer WM, van Egmond M, Niessen FB, Beelen RH, (2011) Macrophages in skin injury and repair. Immunobiology 216: 753-762.
12. Toriseva M, Kahari VM, (2009) Proteinases in cutaneous wound healing. Cell Mol Life Sci 66: 203-224.
13. Barker JH, Kjolseth D, Kim M, Frank J, Bondar I, et al. (1994) The hairless mouse ear: an in vivo model for studying wound neovascularization. Wound Repair Regen 2: 138-143.
14. Meng W, Paunel-Gorgulu A, Flohe S, Hoffmann A, Witte I, et al. (2012) Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice. Crit Care 16: R137.
15. Greenhalgh DG, Gamelli RL, (1987) Is impaired wound healing caused by infection or nutritional depletion? Surgery 102: 306-312.
16. Marti GP, Mohebi P, Liu L, Wang J, Miyashita T, et al. (2008) KGF-1 for wound healing in animal models. Methods Mol Biol 423: 383-391.
17. Dunn L, Prosser HC, Tan JT, Vanags LZ, Ng MK, et al. (2013) Murine model of wound healing. J Vis Exp 75.
18. Frank J, Born K, Barker J, Marzi I, (2003) In Vivo Effect of Tumor Necrosis Factor Alpha on Wound Angiogenesis and Epithelialization. European Journal of Trauma 29: 208-219.
19. Kanno E, Kawakami K, Ritsu M, Ishii K, Tanno H, et al. (2011) Wound healing in skin promoted by inoculation with Pseudomonas aeruginosa PAO1: The critical role of tumor necrosis factor-alpha secreted from infiltrating neutrophils. Wound Repair Regen 19: 608-621.
20. Maish GO, (1998) Tumor necrosis factor binding protein improves incisional wound healing in sepsis. J Surg Res 78: 108-117.
21. Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, et al. (2011) An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest 121: 985-997.
22. Wang XJ, Han G, Owens P, Siddiqui Y, Li AG, (2006) Role of TGF beta-mediated inflammation in cutaneous wound healing. J Investig Dermatol Symp Proc 11: 112-117.
23. Faler BJ, Macsata RA, Plummer D, Mishra L, Sidawy AN, (2006) Transforming growth factor-beta and wound healing. Perspect Vasc Surg Endovasc Ther 18: 55-62.
24. Moali C, Hulmes DJ, (2009) Extracellular and cell surface proteases in wound healing: new players are still emerging. Eur J Dermatol 19: 552-564.
25. Wolfe RR, (1999) Sepsis as a modulator of adaptation to low and high carbohydrate and low and high fat intakes. Eur J Clin Nutr 53Suppl 1: S136-142.