Roles of functional NFKB1 and β-TrCP insertion/deletion polymorphisms in mRNA expression and epithelial ovarian cancer susceptibility

Genetics and Molecular Research

Volumn 12, Issue 3, 2013, Pages 3435-3443

  Huo, Z H ^a   Zhong, H J ^a   Zhu, Y S ^a   Xing, B ^b   Tang, H ^c  

^a NINGXIA MEDICAL UNIVERSITY   (China)

^b Xi'an Mental Health Center   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

transducin repeat containing protein; Epithelial ovarian cancer; Gene expression; Nuclear factor kappa B; Polymorphism

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA;

3' UNTRANSLATED REGION; ARTICLE; CANCER SUSCEPTIBILITY; CANCER TISSUE; CHINESE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; INDEL MUTATION; MAJOR CLINICAL STUDY; MEDICAL DEVICE; NFKB1 GENE; OVARY CARCINOMA; PHENOTYPE; PROMOTER REGION; RISK FACTOR;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INDEL MUTATION; MIDDLE AGED; NEOPLASMS, GLANDULAR AND EPITHELIAL; NF-KAPPA B P50 SUBUNIT; OVARIAN NEOPLASMS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER;

EID: 84884558166     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2013.March.11.6     Document Type: Article

References (32)

1. Annunziata CM, Stavnes HT, Kleinberg L, Berner A, et al. (2010). Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer. Cancer 116: 3276-3284.
2. Basak S and Hoffmann A (2008). Crosstalk via the NF-κB signaling system. Cytokine Growth Factor Rev. 19: 187-197.
3. Bertone-Johnson ER (2005). Epidemiology of ovarian cancer: a status report. Lancet 365: 101-102.
4. Borm ME, van Bodegraven AA, Mulder CJ, Kraal G, et al. (2005). A NFKB1 promoter polymorphism is involved in susceptibility to ulcerative colitis. Int. J. Immunogenet. 32: 401-405.
5. Chen F, Castranova V and Shi X (2001). New insights into the role of nuclear factor-kappaB in cell growth regulation. Am. J. Pathol. 159: 387-397.
6. Chen R, Alvero AB, Silasi DA, Kelly MG, et al. (2008). Regulation of IKKbeta by miR-199a affects NF-κB activity in ovarian cancer cells. Oncogene 27: 4712-4723.
7. Chen S, He Y, Ding J, Jiang Y, et al. (2010). An insertion/deletion polymorphism in the 3' untranslated region of beta-transducin repeat-containing protein (βTrCP) is associated with susceptibility for hepatocellular carcinoma in Chinese. Biochem. Biophys. Res. Commun. 391: 552-556.
8. Dai L, Gu L, Ding C, Qiu L, et al. (2009). TWEAK promotes ovarian cancer cell metastasis via NF-κB pathway activation and VEGF expression. Cancer Lett. 283: 159-167.
9. Fan Y, Yu W, Ye P, Wang H, et al. (2011). NFKB1 insertion/deletion promoter polymorphism increases the risk of advanced ovarian cancer in a Chinese population. DNA Cell Biol. 30: 241-245.
10. Frescas D and Pagano M (2008). Deregulated proteolysis by the F-box proteins SKP2 and βTrCP: tipping the scales of cancer. Nat. Rev. Cancer 8: 438-449.
11. Fuchs SY, Spiegelman VS and Kumar KG (2004). The many faces of βTrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23: 2028-2036.
12. Fyhn AA (1988). Why the Norwegian Nurses' Association says 'no' to nursing assistants in operating rooms. Interview by Bjorn Arild Ostby. Sykepleien 76: 20-25.
13. Gulden C and Olopade OI (2010). Risk assessment and genetic testing for ovarian cancer. AJR Am. J. Roentgenol. 194: 309-310.
14. Hernandez L, Hsu SC, Davidson B, Birrer MJ, et al. (2010). Activation of NF-κB signaling by inhibitor of NF-κB kinase beta increases aggressiveness of ovarian cancer. Cancer Res. 70: 4005-4014.
15. Jemal A, Siegel R, Xu J and Ward E (2010). Cancer statistics, 2010. CA Cancer J. Clin. 60: 277-300.
16. Karban AS, Okazaki T, Panhuysen CI, Gallegos T, et al. (2004). Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum. Mol. Genet. 13: 35-45.
17. Karin M (2006). Nuclear factor-kappaB in cancer development and progression. Nature 441: 431-436.
18. Karin M (2009). NF-κB as a critical link between inflammation and cancer. Cold Spring Harb. Perspect. Biol. 1: a000141.
19. Kudo Y, Guardavaccaro D, Santamaria PG, Koyama-Nasu R, et al. (2004). Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis. Mol. Cell Biol. 24: 8184-8194.
20. Lin YG, Kunnumakkara AB, Nair A, Merritt WM, et al. (2007). Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin. Cancer Res. 13: 3423-3430.
21. Lo SS, Chen JH, Wu CW and Lui WY (2009). Functional polymorphism of NFKB1 promoter may correlate to the susceptibility of gastric cancer in aged patients. Surgery 145: 280-285.
22. Maeda S and Omata M (2008). Inflammation and cancer: role of nuclear factor-kappaB activation. Cancer Sci. 99: 836-842.
23. Mani A and Gelmann EP (2005). The ubiquitin-proteasome pathway and its role in cancer. J. Clin. Oncol. 23: 4776-4789.
24. Naugler WE and Karin M (2008). NF-κB and cancer-identifying targets and mechanisms. Curr. Opin. Genet. Dev. 18: 19-26.
25. Oliver J, Gomez-Garcia M, Paco L, Lopez-Nevot MA, et al. (2005). A functional polymorphism of the NFKB1 promoter is not associated with ulcerative colitis in a Spanish population. Inflamm. Bowel Dis. 11: 576-579.
26. Ougolkov A, Zhang B, Yamashita K, Bilim V, et al. (2004). Associations among βTrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-κB in colorectal cancer. J. Natl. Cancer Inst. 96: 1161-1170.
27. Sun XF and Zhang H (2007). NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases. Histol. Histopathol. 22: 1387-1398.
28. Tang T, Cui S, Deng X, Gong Z, et al. (2010). Insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for superficial bladder cancer in Chinese. DNA Cell Biol. 29: 9-12.
29. Wang X, Wu X, Wang C, Zhang W, et al. (2010). Transcriptional suppression of breast cancer resistance protein (BCRP) by wild-type p53 through the NF-κB pathway in MCF-7 cells. FEBS Lett. 584: 3392-3397.
30. Westbrook TF, Hu G, Ang XL, Mulligan P, et al. (2008). SCF βTrCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 452: 370-374.
31. Zhou B, Rao L, Li Y, Gao L, et al. (2009). A functional insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for nasopharyngeal carcinoma. Cancer Lett. 275: 72-76.
32. Zhou B, Qie M, Wang Y, Yan L, et al. (2010). Relationship between NFKB1-94 insertion/deletion ATTG polymorphism and susceptibility of cervical squamous cell carcinoma risk. Ann. Oncol. 21: 506-511.