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From the same starting 2-bomobenzyl bromide, 20 was also obtained by the magnesium way in three steps via the following: (i) homocoupling of an in situ formed benzyl Grignard; (ii) iodination of two aromatic bromide positions and iron catalyzed homocoupling of an in situ formed aryl magnesium (global yield: 19%)
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From the same starting 2-bomobenzyl bromide, 20 was also obtained by the magnesium way in three steps via the following: (i) homocoupling of an in situ formed benzyl Grignard; (ii) iodination of two aromatic bromide positions and iron catalyzed homocoupling of an in situ formed aryl magnesium (global yield: 19%): Cahiez, G.; Chaboche, C.; Mahuteau-Betzer, F.; Ahr, M. Org. Lett. 2005, 7, 1943
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During the preparation of this manuscript the Pd-catalyzed cross-coupling of aryl halides with organolithium derivatives was published. This Palladium variant of the nickel system we described in ref 12 involves a strategy based on preformed aryllithiums, on halogen-lithium exchanges, and on direct metalations (as in the Fe-catalytic system descibed in this paper for the homocoupling)
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During the preparation of this manuscript the Pd-catalyzed cross-coupling of aryl halides with organolithium derivatives was published. This Palladium variant of the nickel system we described in ref 12 involves a strategy based on preformed aryllithiums, on halogen-lithium exchanges, and on direct metalations (as in the Fe-catalytic system descibed in this paper for the homocoupling): Giannerini, M.; Fananas-Mastal, M.; Feringa Ben, L. Nat. Chem. 2013, 5, 667
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