Modeling the proton sponge hypothesis: Examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling

Journal of Biomaterials Science, Polymer Edition

Volumn 24, Issue 4, 2013, Pages 398-416

  Freeman, Eric C ^a   Weiland, Lisa M ^a   Meng, Wilson S ^b  

^a University of Pittsburgh   (United States)

^b DUQUESNE UNIVERSITY   (United States)

Author keywords

Dendrimer; Drug delivery; Gene therapy; Modeling; Proton sponge

Indexed keywords

BUFFERING BEHAVIORS; CELLULAR SIMULATION; COMPUTATIONAL STUDIES; INTRACELLULAR GENE DELIVERY; MULTI-SCALE MODELING; PROTON SPONGE; THERAPEUTIC GENES; TRANSFECTION EFFICIENCY;

ACIDIFICATION; COMPUTER SIMULATION; DENDRIMERS; DRUG DELIVERY; GENE THERAPY; GENE TRANSFER; MODELS; NUCLEIC ACIDS; POLYOLS;

FUNCTIONAL POLYMERS;

BUFFER; DENDRIMER; ION CHANNEL; NUCLEIC ACID; PROTON; ANION; CHLORINE;

ACIDIFICATION; ARTICLE; CELL STIMULATION; ENDOSOME; FLOW RATE; GENE DELIVERY SYSTEM; INTRACELLULAR SIGNALING; OSMOTIC PRESSURE; PRIORITY JOURNAL; PROTON TRANSPORT; BIOLOGICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; GENE TRANSFER; METABOLISM; PH;

ANIONS; BUFFERS; CHLORINE; COMPUTER SIMULATION; DENDRIMERS; ENDOSOMES; GENE TRANSFER TECHNIQUES; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; OSMOTIC PRESSURE; PROTONS;

EID: 84884540320     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1080/09205063.2012.690282     Document Type: Article

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