The Human WBSCR22 Protein Is Involved in the Biogenesis of the 40S Ribosomal Subunits in Mammalian Cells

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Õunap, Kadri ^a   Käsper, Ly ^a   Kurg, Ants ^a   Kurg, Reet ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

40S RIBOSOME RNA; HISTONE METHYLTRANSFERASE; RIBOSOME RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WBSCR22 PROTEIN;

ANIMAL CELL; ARTICLE; BIOGENESIS; BIOSYNTHESIS; BUD23 GENE; CELL GROWTH; CELL NUCLEUS; CONTROLLED STUDY; DELETION MUTANT; FUNGAL GENE; GENE DELETION; GENE LOCATION; GENETIC COMPLEMENTATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; MAMMAL CELL; NONHUMAN; PROTEIN DEPLETION; RNA PROCESSING; RNA STABILITY; WBSCR22 GENE; WILLIAMS BEUREN SYNDROME;

CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; FUNGAL PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; METHYLTRANSFERASES; RIBOSOME SUBUNITS, SMALL, EUKARYOTIC; RNA PRECURSORS; SEQUENCE DELETION; YEASTS;

EID: 84884528223     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075686     Document Type: Article

References (30)

1. Petrossian TC, Clarke SG, (2011) Uncovering the human methyltransferasome. Mol Cell Proteomics 10. PubMed: 20930037.
2. Martin JL, McMillian F, (2002) SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold. Curr Opin Struct Biol 12: 783-793. doi:10.1016/S0959-440X(02)00391-3. PubMed: 12504684.
3. Albert M, Helin K, (2010) Histone methyltransferases in cancer. Semin Cell Dev Biol 21: 209-220. doi:10.1016/j.semcdb.2009.10.007. PubMed: 19892027.
4. Nakazawa Y, Arai H, Fujita A, (2011) The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis. Cancer Res 71: 1146-1155. doi:10.1158/0008-5472.CAN-10-2695. PubMed: 21148752.
5. Tiedemann R, Zhu Y, Schmidt J, Shi C, Sereduk C, et al. (2012) Identification of molecular vulnerabilities in human multiple myeloma cells by RNAi lethality screening of the druggable genome. Cancer Res (in press).
6. Schubert C, (2009) The genomic basis of the Williams - Beuren syndrome. Cell Mol Life Sci 66: 1178-1197. doi:10.1007/s00018-008-8401-y. PubMed: 19039520.
7. Scherer S, Osborne L, (2006) Williams-Beuren Syndrome. In: Lupski J, Stankiewicz P, eds. Genomic Disorders. Totowa, NJ: Humana Press. pp. pp. 221-236.
8. Merla G, Howald C, Henrichsen CN, Lyle R, Wyss C, et al. (2006) Submicroscopic Deletion in Patients with Williams-Beuren Syndrome Influences Expression Levels of the Nonhemizygous Flanking Genes. Am J Hum Genet 79: 332-341. doi:10.1086/506371. PubMed: 16826523.
9. White J, Li Z, Sardana R, Bujnicki JM, Marcotte EM, et al. (2008) Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits. Mol Cell Biol 28: 3151-3161. doi:10.1128/MCB.01674-07. PubMed: 18332120.
10. Li Z, Lee I, Moradi E, Hung NJ, Johnson AW, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLOS Biol 10: e1000213. PubMed: 19806183.
11. Zemp I, Wild T, O'Donohue MF, Wandrey F, Widmann B, et al. (2009) Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2. J Cell Biol 185: 1167-1180. doi:10.1083/jcb.200904048. PubMed: 19564402.
12. Rouquette J, Choesmel V, Gleizes PE, (2005) Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells. EMBO J 24: 2862-2872. doi:10.1038/sj.emboj.7600752. PubMed: 16037817.
13. Henras AK, Soudet J, Gérus M, Lebaron S, Caizergues-Ferrer M, et al. (2008) The post-transcriptional steps of eukaryotic ribosome biogenesis. Cell Mol Life Sci 65: 2334-2359. doi:10.1007/s00018-008-8027-0. PubMed: 18408888.
14. Ohbayashi I, Konishi M, Ebine K, Sugiyama M, (2011) Genetic identification of Arabidopsis RID2 as an essential factor involved in pre-rRNA processing. Plant J 67: 49-60. doi:10.1111/j.1365-313X.2011.04574.x. PubMed: 21401745.
15. Sardana R, Johnson AW, (2012) The methyltransferase adaptor protein Trm112 is involved in biogenesis of both ribosomal subunits. Mol Biol Cell 23: 4313-4322. doi:10.1091/mbc.E12-05-0370. PubMed: 22956767.
16. Figaro S, Wacheul L, Schillewaert S, Graille M, Huvelle E, et al. (Apr 9(2012) Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575. Mol Cell Biol, Apr 9. [Epub ahead of print]. PubMed: 22493060.
17. Henrichsen CN, Csárdi G, Zabot MT, Fusco C, Bergmann S, et al. (2011) Using transcription modules to identify expression clusters perturbed in Williams-Beuren syndrome. PLOS Comput Biol 7: e1001054. PubMed: 21304579.
18. Wild T, Horvath P, Wyler E, Widmann B, Badertscher L, et al. (2010) A protein inventory of human ribosome biogenesis reveals an essential function of exportin. p. 5 in 60S subunit export. PLoS Biol 8: e1000522.
19. Carron C, O'Donohue MF, Choesmel V, Faubladier M, Gleizes PE, (2011) Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals. Nucleic Acids Res 39: 280-291. doi:10.1093/nar/gkq734. PubMed: 20805244.
20. Boisvert FM, Van Koningsbruggen S, Navascués J, Lamond AI, (2007) The multifunctional nucleolus. Nat Rev Mol Cell Biol 8: 574-585. doi:10.1038/nrm2184. PubMed: 17519961.
21. Tschochner H, Hurt E, (2003) Pre-ribosomes on the road from the nucleolus to the cytoplasm. Trends Cell Biol 13: 255-263. doi:10.1016/S0962-8924(03)00054-0. PubMed: 12742169.
22. Schäfer T, Strauss D, Petfalski E, Tollervey D, Hurt E, (2003) The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes. EMBO J, 22: 1370-1380. PubMed: 12628929.
23. Lafontaine D, Vandenhaute J, Tollervey D, (1995) The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast. Genes Dev 9: 2470-2481. doi:10.1101/gad.9.20.2470. PubMed: 7590228.
24. Lafontaine DL, Preiss T, Tollervey D, (1998) Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? Mol Cell Biol 4: 2360-2370. PubMed: 9528805.
25. Leulliot N, Bohnsack MT, Graille M, Tollervey D, Van Tilbeurgh H, (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36: 629-639. PubMed: 18063569.
26. van Riggelen J, Yetil A, Felsher DW, (2010) MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer 10: 301-309. doi:10.1038/nri2761. PubMed: 20332779.
27. Belin S, Beghin A, Solano-Gonzàlez E, Bezin L, Brunet-Manquat S, et al. (2009) Dysregulation of ribosome biogenesis and translational capacity is associated with tumor progression of human breast cancer cells. PLOS ONE 4(9):: e7147. doi:10.1371/journal.pone.0007147. PubMed: 19779612.
28. Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D, (2007) Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. Biochem J 404: 373-381. doi:10.1042/BJ20061597. PubMed: 17381424.
29. Wang H, Xiao W, Zhou Q, Chen Y, Yang S, et al. (2009) Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation. Cell Res 19: 1150-1164. doi:10.1038/cr.2009.99. PubMed: 19687802.
30. Saijou E, Fujiwara T, Suzaki T, Inoue K, Sakamoto H, (2004) RBD-1, a nucleolar RNA-binding protein, is essential for Caenorhabditis elegans early development through 18S ribosomal RNA processing. Nucleic Acids Res 10: 1028-1036. PubMed: 14872060.