α-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigata

Fitoterapia

Volumn 90, Issue , 2013, Pages 30-37

  Wang, Zhi Wei ^a   Wang, Jun Song ^a   Luo, Jun ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Glucosidase inhibitor; Oleanane triterpene; Uncaria laevigata; Ursane triterpene

Indexed keywords

19ALPHA HYDROXY 3,6 DIOXO 24 NOROLEAN 12 EN 28 OIC ACID; 19ALPHA HYDROXY 3,6 DIOXO OLEAN 12 EN 28 OIC ACID; 19ALPHA HYDROXY 3,6 DIOXO URS 1(2),12 DIEN 28 OIC ACID; 3BETA 19ALPHA DIHYDROXY 6 OXO OLEAN 12 EN 28 OIC ACID; 3BETA 19ALPHA DIHYDROXY 6BETA 7BETA EPOXYL URS 12 EN 28 OIC ACID; 3BETA HYDROXY 30 METHOXY 6 OXO URS 12,19(20)DIEN 28 OIC ACID; 6ALPHA,19ALPHA DIHYDROXY 3 OXO OLEAN 12 EN 28 OIC ACID; 6BETA 19ALPHA DIHYDROXY 3 OXO 24 NOROLEAN 12 EN 28 OIC ACID; 6BETA 19ALPHA DIHYDROXY 3 OXO 24 NORURS 12 EN 28 OIC ACID; ALCOHOL; ALPHA GLUCOSIDASE; PLANT EXTRACT; TRITERPENOID; UNCARIA LAEVIGATA EXTRACT; UNCLASSIFIED DRUG; URSOLIC ACID;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ISOLATION; ENZYME INHIBITION; IC 50; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE IMAGING; PLANT STEM; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; UNCARIA; UNCARIA LAEVIGATA;

OLEANANE TRITERPENE; UNCARIA LAEVIGATA; URSANE TRITERPENE; Α-GLUCOSIDASE INHIBITOR;

ALPHA-GLUCOSIDASES; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; OLEANOLIC ACID; PLANT BARK; PLANT EXTRACTS; PLANT STEMS; TRITERPENES; UNCARIA;

EID: 84884478322     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2013.07.005     Document Type: Article

References (18)

1. G. Chandramohan, S. Ignacimuthu, and K.V. Pugalendi A novel compound from Casearia esculenta (Roxb.) root and its effect on carbohydrate metabolism in streptozotocin-diabetic rats Eur J Pharmacol 590 2008 437 443
2. Zareen S. Atta-ur-Rahman, M.I. Choudhary, M.N. Akhtar, and S.N. Khan α-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus J Nat Prod 71 2008 910 913 (Pubitemid 351841450)
3. G.-L. Li, J.-Y. He, A. Zhang, Y. Wan, B. Wang, and W.-H. Chen Toward potent α-glucosidase inhibitors based on xanthones: a closer look into the structure-activity correlations Eur J Med Chem 46 2011 4050 4055
4. Y. Wang, L. Ma, C. Pang, M. Huang, Z. Huang, and L. Gu Synergetic inhibition of genistein and D-glucose on α-glucosidase Bioorg Med Chem Lett 14 2004 2947 2950 (Pubitemid 38569769)
5. V.H. Lillelund, H.H. Jensen, X.F. Liang, and M. Bols Recent developments of transition-state analogue glycosidase inhibitors of non-natural product origin Chem Rev 102 2002 515 554
6. C.-J. Yang, J. Zhang, and D.-G. Wu Triterpenoids from Uncaria rhynchophylla Acta Bot Yunnanica 17 1995 209 214
7. M. Kitajima, K.-I. Hashimoto, M. Yokoya, H. Takayama, M. Sandoval, and N. Aimi Two new nor-triterpene glycosides from peruvian "Uña de Gato" (Uncaria tomentosa) J Nat Prod 66 2003 320 323 (Pubitemid 36278257)
8. A. Domingues, A. Sartori, M.A. Golim, L.M.M. Valente, L.C. da Rosa, and L.L.W. Ishikawa Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both? J Ethnopharmacol 137 2011 635 642
9. Y.-C. Lai, C.-K. Chen, S.-F. Tsai, and S.-S. Lee Triterpenes as α-glucosidase inhibitors from Fagus hayatae Phytochemistry 74 2012 206 211
10. P. Wafo, R.S.T. Kamdem, Z. Ali, S. Anjum, S.N. Khan, and A. Begum Duboscic acid: a potent α-glucosidase inhibitor with an unprecedented triterpenoidal carbon skeleton from Duboscia macrocarpa Org Lett 12 2010 5760 5763
11. X. Wan, X.-B. Wang, M.-H. Yang, J.-S. Wang, and L.-Y. Kong Dimerization of piceatannol by Momordica charantia peroxidase and α-glucosidase inhibitory activity of the biotransformation products Bioorg Med Chem 19 2011 5085 5092
12. J.-G. Luo, X.-B. Wang, L. Ma, and L.-Y. Kong Gypsophin: a novel α-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana Bioorg Med Chem Lett 17 2007 4460 4463 (Pubitemid 47058963)
13. H.-X. Xu, F.-Q. Zeng, M. Wan, and K.-Y. Sim Anti-HIV triterpene acids from Geum japonicum J Nat Prod 59 1996 643 645 (Pubitemid 26264625)
14. T.K.K. Diyabalanage, G. Percy Wannigama, A. Weerasuriya, L. Jayasinghe, and P. Simmonds Ursene carboxylic acids of Uncaria elliptica Phytochemistry 40 1995 1311 1312
15. G. Sun, X. Zhang, X. Xu, J. Yang, M. Zhong, and J. Yuan A new triterpene from Uncaria macrophylla and its antitumor activity Molecules 17 2012 1883 1889
16. Z.-Y. Tao, Y.-H. Yi, and Q.-Z. Xu Studies on the chemical constituents of Uncaria yunanensis Hsia. C. C. Acta Pharmacol Sin 36 2001 120 122 (Pubitemid 33695850)
17. R. Aquino, N. De Tommasi, F. De Simone, and C. Pizza Triterpenes and quinovic acid glycosides from Uncaria tomentosa Phytochemistry 45 1997 1035 1040 (Pubitemid 27265695)
18. T. Morikawa, H. Oominami, H. Matsuda, and M. Yoshikawa Four new ursane-type triterpenes, olibanumols K, L, M, and N, from traditional Egyptian medicine olibanum, the gum-resin of Boswellia carterii Chem Pharm Bull 58 2010 1541 1544