Structure-guided discovery of new deaminase enzymes

Journal of the American Chemical Society

Volumn 135, Issue 37, 2013, Pages 13927-13933

  Hitchcock, Daniel S ^a   Fan, Hao ^b,c   Kim, Jungwook ^d   Vetting, Matthew ^d   Hillerich, Brandan ^d   Seidel, Ronald D ^d   Almo, Steven C ^d   Shoichet, Brian K ^b   Sali, Andrej ^b   Raushel, Frank M ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDOHYDROLASE SUPERFAMILY; COMPUTATIONAL BIOLOGY; MOLECULAR ENZYMOLOGY; MULTI-DISCIPLINARY APPROACH; S-ADENOSYLHOMOCYSTEINE; SUBSTRATE SPECIFICITY; THREE-DIMENSIONAL STRUCTURE; X-RAY DIFFRACTION METHOD;

BIOINFORMATICS; PROTEINS; X RAY DIFFRACTION;

ENZYMES;

2 OXOADENINE; 5' METHYLTHIOADENOSINE; 8 OXOADENINE; ADENINE DERIVATIVE; ADENOSINE; ADENOSINE DERIVATIVE; AMIDASE; BACTERIAL ENZYME; DEAMINASE; GUANINE; GUANINE DEAMINASE; S ADENOSYLHOMOCYSTEINE; TM 0936; UNCLASSIFIED DRUG; XANTHINE;

AGROBACTERIUM VITIS; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONVERGENT EVOLUTION; CRYSTAL STRUCTURE; DEAMINATION; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME STRUCTURE; METAL BINDING; MOLECULAR DOCKING; MOORELLA THERMOACETICA; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTON TRANSPORT; RHIZOBIUM; THERMOTOGA MARITIMA; X RAY DIFFRACTION;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ASSAYS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEOSIDE DEAMINASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84884469132     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4066078     Document Type: Article

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