Antiproliferative and apoptosis inducing activity of Markhamia tomentosa leaf extract on HeLa cells

Journal of Ethnopharmacology

Volumn 149, Issue 3, 2013, Pages 745-749

  Ibrahim, Bolanle ^a   Sowemimo, Abimbola ^a   Spies, Luanne ^b   Koekomoer, Trevor ^b   Van De Venter, Maryna ^b   Odukoya, Olukemi A ^a  

^a UNIVERSITY OF LAGOS   (Nigeria)

^b NELSON MANDELA METROPOLITAN UNIVERSITY   (South Africa)

Author keywords

Apoptosis; Cytotoxicity; HeLa; Markhamia tomentosa

Indexed keywords

MARKHAMIA TOMENTOSA EXTRACT; MELPHALAN; PHOSPHATIDYLSERINE; PLANT EXTRACT; UNCLASSIFIED DRUG; VINCRISTINE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTEMIA; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IC 50; LD 50; LETHALITY; MARKHAMIA TOMENTOSA; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PLANT LEAF;

ARTEMIA; BIGNONIACEAE; MARKHAMIA;

APOPTOSIS; CYTOTOXICITY; HELA; MARKHAMIA TOMENTOSA;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ARTEMIA; BIGNONIACEAE; CELL CYCLE; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; FLOW CYTOMETRY; HELA CELLS; HUMANS; LETHAL DOSE 50; MCF-7 CELLS; MEDICINE, AFRICAN TRADITIONAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; PLANT EXTRACTS; PLANT LEAVES; VERO CELLS;

EID: 84884415286     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.07.040     Document Type: Article

References (24)

1. J.E. Anderson, C. Goetz, and J.L. McLaughlin A blind comparison of simple bench-top bioassays and human tumour cell cytotoxicities as antitumuor prescreens Phytochemical Analysis 2 1991 107 111
2. T.I. Borokini, and F.O. Omotayo Phytochemical and ethnobotanical study of some selected medicinal plants from Nigeria Journal of Medicinal Plant Research 6 2012 1106 1118
3. H.M. Burkill The Useful Plants of West Tropical Africa vol. 1 1985 Royal Botanic Gardens Kew 252 258
4. S.K. Chauthe, S.B. Bharate, G. Periyasamy, A. Khanna, K.K. Bhutani, P.D. Mishra, and I.P. Singh One pot synthesis and anticancer activity of dimeric phloroglucinols Bioorganic and Medicinal Chemistry Letters 22 2012 2251 2256
5. C.Y. Chen, Y.B. Cheng, S.Y. Chen, C.T. Chien, Y.H. Kuo, J.H. Guh, A.T. Khalil, and Y.C. Shen New bioactive clerodane diterpenoids from the roots of Casearia membranacea Chemistry and Biodiversity 5 2008 162 167
6. D.R. Green, and J.C. Reed Mitochondria and apoptosis Science 281 1998 1309 1312
7. M.L. Hooper, N. Toft, S. Webb, and C.C. Bird Apoptosis and carcinogenesis British Journal of Cancer 80 1999 34 37
8. P.J. Houghton Chemistry and biological activity of natural and semi-synthetic chromone alkaloids Studies in Natural Products Chemistry 21 2000 123 155
9. A. Kamuhabwa, C. Nshimo, and P. De Witte Cytotoxicity of some medicinal plants used in Tanzanian traditional medicine Journal of Ethnopharmacology 70 2000 143 149
10. C. Koopman, C.P. Reutelingsperger, G.A. Kuijten, R.M. Keehnen, S.T. Pals, and M.H. Van Oers Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis Blood 84 1994 1415 1420
11. A.V. Krishnaraju, V.N. Rao-Tayi, D. Sundararaju, M. Vanisree, H.S. Tsay, and G.V. Subbaraju Assessment of bioactivity of Indian medicinal plant using brine shrimp (Artemia salina) lethality assay International Journal of Applied Science and Engineering 3 2005 125 134
12. J. Lee, W. Hwang, and S. Lim Antioxidant anticancer activities of organic extract of Platycodon grandiflorum A. De Candolle roots Journal of Ethnopharmacology 93 2004 409 415
13. J.L. McLaughlin, L.L. Rogers, and J.E. Anderson The use of biological assays to evaluate botanicals Drug Information Journal 32 1998 513 524
14. S.J. Martin, C.P. Reutelingsperger, A.J. McGahon, J.A. Rader, R.C. van Schie, D.M. LaFace, and D.R. Green Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition of overexpression of Bcl-2 and Abl Journal of Experimental Medicine 182 1995 1545 1556
15. T. Mossman Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 65 1983 55 63
16. A. Rasul, and T. Ma In vitro cytotoxic screening of 300 selected Chinese medicinal herbs against human gastric adenocarcinoma SGC-7901 cells African Journal of Pharmacy and Pharmacology 6 2012 592 600
17. S. Sheikh, A. Srivastava, R. Tripathi, S. Tripathi, V.P. Trivedi, and R.C. Saxena Toxicity of a novel herbomineral preparation Las01 on human cancer cell lines and its safety profile in humans and animals Evidence-based Complementary and Alternative Medicine 2012 10.1155/2012/948375
18. A.M. Shoeib, M. Elgayyar, P.S. Dudrick, J.L. Bell, and P.K. Tithof In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone International Journal of Oncology 22 2003 107 113
19. A.A. Sowemimo, M. Van de Venter, L. Baatjies, and T. Koekemoer Cytotoxic activity of selected Nigerian plants African Journal of Traditional, Complementary and Alternative Medicines 6 2009 526 528
20. V. Srivastava, A.S. Negi, J.K. Kumar, M.M. Gupta, and S.P.S. Khanuja Plant-based anticancer molecules: a chemical and biological profile of some important leads Bioorganic and Medicinal Chemistry 13 2005 5892 5908
21. V. Tong, X.W. Terg, T.K.H. Chang, and F.S. Abbott Valproic acid II: effects on oxidative stress, mitochondria membrane potential and cytotoxicity in glutathione-depleted rat hepatocytes Toxicological Sciences 86 2005 436 443
22. A.C. Wardlaw Practical statistics for experimental biologists 1985 John Wiley and Sons Chichester
23. J. Wu, Wu, and B.B. Yang Anticancer activity of Hemsleya amabilis extract Life Sciences 71 2002 2161 2170
24. Y. Yasumara, and M. Kawakita The research for the SV40 by means of tissue culture technique Nippon Rinsho 21 1963 1201 1219