Recent advances in biological therapies for disc degeneration: Tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs

Current Opinion in Biotechnology

Volumn 24, Issue 5, 2013, Pages 872-879

  Hudson, Katherine D ^a   Alimi, Marjan ^b   Grunert, Peter ^b   Härtl, Roger ^a,b   Bonassar, Lawrence J ^a  

^a Cornell University   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL THERAPIES; GLYCOSAMINOGLYCANS; INTERVERTEBRAL DISCS; ORGAN CULTURE SYSTEM; SIGNAL INTENSITIES; SURGICAL INTERVENTIONS; TISSUE-ENGINEERED SCAFFOLDS; TISSUE-ENGINEERED THERAPIES;

IMPLANTS (SURGICAL); TISSUE ENGINEERING;

TISSUE;

ALGINIC ACID; CHITOSAN; COLLAGEN; GROWTH FACTOR; POLYGLACTIN; PROTEOGLYCAN; TISSUE SCAFFOLD;

ANNULUS FIBROSUS; BIOCOMPATIBILITY; BIOLOGICAL THERAPY; CELL GROWTH; CELL VIABILITY; COMPOSITE MATERIAL; CULTURE MEDIUM; INTERVERTEBRAL DISK DEGENERATION; MATERIAL COATING; MATERIAL STATE; NUCLEUS PULPOSUS; ORGAN CULTURE; PRIORITY JOURNAL; PROCESS DEVELOPMENT; REVIEW; TISSUE ENGINEERING; TISSUE REGENERATION; TISSUE STRUCTURE;

EID: 84884412264     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2013.04.012     Document Type: Review

References (49)

1. Martin B.I., Deyo R.A., Mirza S.K., Turner J.A., Comstock B.A., Hollingworth W., Sullivan S.D. Expenditures and health status among adults with back and neck problems. J Am Med Assoc 2008, 299(February):656-664.
2. Raj P.P. Intervertebral disc: pathophysiology-treatment. Pain Pract 2008, 8:18-44.
3. Antoniou J., Steffen T., Nelson F., Winterbottom N., Hollander A.P., Poole R.A., Aebi M. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest 1996, 98:996-1003.
4. Whatley B.R., Wen X. Intervertebral disc (IVD): structure, degeneration, repair and regeneration. Mater Sci Eng C 2012, 32(March):61-77.
5. Cowan J.A., Dimick J.B., Wainess R., Upchurch G.R., Chandler W.F., La Marca F. Changes in utilization of spinal fusion. Neurosurgery 2006, 58:15-20.
6. Gawri R., Mwale F., Ouellet J., Roughley P.J., Steffen T., Antoniou J., Haglund L. Development of an organ culture system for long-term survival of the intact human intervertebral disc. Spine 2011, 36(October):1835-1842.
7. Haschtmann D., Stoyanov J.V., Ettinger L., Nolte L.-P., Ferguson S.J. Establishment of a novel intervertebral disc/endplate culture model: analysis of an ex vivo in vitro whole-organ rabbit culture system. Spine 2006, 31(December):2918-2925.
8. Haglund L., Moir J., Beckman L., Mulligan K.R., Jim B., Roughley P., Steffen T. Development of a bioreactor for axially loaded intervertebral disc organ culture. Tissue Eng C: Methods 2011, 17:1011-1019.
9. Illien-Jünger S., Gantenbein-Ritter B., Grad S., Lezuo P., Ferguson S.J., Alini M., Ito K. The combined effects of limited nutrition and high-frequency loading on intervertebral discs with endplates. Spine 2010, 35(September):1744-1752.
10. Illien-Jünger S., Pattappa G., Peroglio M., Benneker L.M., Stoddart M.J., Sakai D., Mochida J., Grad S., Alini M. Homing of mesenchymal stem cells in induced degenerative intervertebral discs in a whole organ culture system. Spine 2012, 37(October):1865-1873.
11. Halloran D.O., Grad S., Stoddart M., Dockery P., Alini M., Pandit A.S. An injectable cross-linked scaffold for nucleus pulposus regeneration. Biomaterials 2008, 29(February):438-447.
12. Revell P.a., Damien E., Di Silvio L., Gurav N., Longinotti C., Ambrosio L. Tissue engineered intervertebral disc repair in the pig using injectable polymers. J Mater Sci: Mater Med 2007, 18(February):303-308.
13. Richardson S.M., Hughes N., Hunt J.a., Freemont A.J., Hoyland J.a. Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials 2008, 29(January):85-93.
14. Ganey T., Libera J., Moos V., Alasevic O., Fritsch K.-G., Meisel H.J., Hutton W.C. Disc chondrocyte transplantation in a canine model: a treatment for degenerated or damaged intervertebral disc. Spine 2003, 28(December):2609-2620.
15. Meisel H.J., Siodla V., Ganey T., Minkus Y., Hutton W.C., Alasevic O.J. Clinical experience in cell-based therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc. Biomol Eng 2007, 24(February):5-21.
16. Ganey T., Hutton W.C., Moseley T., Hedrick M., Meisel H.-J. Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: experiments in a canine model. Spine 2009, 34(October):2297-2304.
17. Gorensek M., Jaksimović C., Kregar-Velikonja N., Gorensek M., Knezevic M., Jeras M., Pavlovcic V., Cör A. Nucleus pulposus repair with cultured autologous elastic cartilage derived chondrocytes. Cell Mol Biol Lett 2004, 9(April):363-373.
18. Acosta F.L., Metz L., Adkisson H.D., Liu J., Carruthers-Liebenberg E., Milliman C., Maloney M., Lotz J.C. Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells. Tissue Eng A 2011, 17(December):3045-3055.
19. Bron J.L., Vonk L.A., Smit T.H., Koenderink G.H. Engineering alginate for intervertebral disc repair. J Mech Behav Biomed Mater 2011, 4(October):1196-1205.
20. Park S.-H., Kaplan D. Silk-fibrin/hyaluronic acid composite gels for nucleus pulposus tissue regeneration. Tissue Eng 2011, 17:2999-3009.
21. Lee K.-I., Moon S.-H., Kim H., Kwon U.-H., Kim H.-J., Park S.-N., Suh H., Lee H.-M., Kim H.-S., Chun H.-J., Kwon I.-K., Jang J.-W. Tissue engineering of the intervertebral disc with cultured nucleus pulposus cells using atelocollagen scaffold and growth factors. Spine 2012, 37(March):452-458.
22. Abbushi A., Endres M., Cabraja M., Kroppenstedt S.N., Thomale U.W., Sittinger M., Hegewald A.A., Morawietz L., Lemke A.-J., Bansemer V.-G., Kaps C., Woiciechowsky C. Regeneration of intervertebral disc tissue by resorbable cell-free polyglycolic acid-based implants in a rabbit model of disc degeneration. Spine 2008, 33(June):1527-1532.
23. Ruan D., Xin H., Zhang C., Wang C., Xu C., Ph D., Li C., He Q. Experimental intervertebral disc regeneration with tissue-engineered composite in a canine model. Tissue Eng A 2010, 16:2381-2389.
24. Li C.-Q., Huang B., Luo G., Zhang C.-Z., Zhuang Y., Zhou Y. Construction of collagen II/hyaluronate/chondroitin-6-sulfate tri-copolymer scaffold for nucleus pulposus tissue engineering and preliminary analysis of its physico-chemical properties and biocompatibility. J Mater Sci: Mater Med 2010, 21(February):741-751.
25. Huang B., Zhuang Y., Li C.-Q., Liu L.-T., Zhou Y. Regeneration of the intervertebral disc with nucleus pulposus cell-seeded collagen II/hyaluronan/chondroitin-6-sulfate tri-copolymer constructs in a rabbit disc degeneration model. Spine 2011, 36(December):2252-2259.
26. Gupta M.S., Cooper E.S., Nicoll S.B. Transforming growth factor-beta 3 stimulates cartilage matrix elaboration by human marrow-derived carboxymethylcellulose hydrogels: potential for nucleus pulposus replacement. Tissue Eng A 2011, 17:2903-2910.
27. Haschtmann D., Ferguson S.J., Stoyanov J.V. BMP-2 and TGF-β3 do not prevent spontaneous degeneration in rabbit disc explants but induce ossification of the annulus fibrosus. Eur Spine J 2012, 21(September):1724-1733.
28. Nerurkar N.L., Elliott D.M., Mauck R.L. Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering. J Orthop Res 2007, 25:1018-1028.
29. Nerurkar N.L., Mauck R.L., Elliott D.M. ISSLS prize winner: integrating theoretical and experimental methods for functional tissue engineering of the annulus fibrosus. Spine 2008, 33(December):2691-2701.
30. Nerurkar N.L., Baker B.M., Sen S., Wible E.E., Elliott D.M., Mauck R.L. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nat Mater 2009, 8(December):986-992.
31. Chang G., Kim H.-J., Kaplan D., Vunjak-Novakovic G., Kandel R.A. Porous silk scaffolds can be used for tissue engineering annulus fibrosus. Eur Spine J 2007, 16(November):1848-1857.
32. Chang G., Kim H.J., Vunjak-Novakovic G., Kaplan D.L., Kandel R. Enhancing annulus fibrosus tissue formation in porous silk scaffolds. J Biomed Mater Res A 2010, 92(January):43-51.
33. Bhattacharjee M., Miot S., Gorecka A., Singha K., Loparic M., Dickinson S., Das A., Bhavesh N.S., Ray A.R., Martin I., Ghosh S. Oriented lamellar silk fibrous scaffolds to drive cartilage matrix orientation: towards annulus fibrosus tissue engineering. Acta Biomater 2012, 8(September):3313-3325.
34. See E.Y.-S., Toh S.L., Goh J.C.-H. Effects of radial compression on a novel simulated intervertebral disc-like assembly using bone marrow-derived mesenchymal stem cell cell-sheets for annulus fibrosus regeneration. Spine 2011, 36(October):1744-1751.
35. Sato M., Asazuma T., Ishihara M., Ishihara M., Kikuchi T., Kikuchi M., Fujikawa K. An experimental study of the regeneration of the intervertebral disc with an allograft of cultured annulus fibrosus cells using a tissue-engineering method. Spine 2003, 28(March):548-553.
36. Shao X., Hunter C.J. Developing an alginate/chitosan hybrid fiber scaffold for annulus fibrosus cells. J Biomed Mater Res A 2007, 82:701-710.
37. Pan Y., Chu T., Dong S., Hao Y., Ren X., Wang J., Wang W., Li C., Zhang Z., Zhou Y. Cells scaffold complex for intervertebral disc anulus fibrosus tissue engineering: in vitro culture and product analysis. Mol Biol Rep 2012, 39(September):8581-8594.
38. Le Visage C., Yang S.-H., Kadakia L., Sieber A.N., Kostuik J.P., Leong K.W. Small intestinal submucosa as a potential bioscaffold for intervertebral disc regeneration. Spine 2006, 31(October):2423-2430. [discussion 2431].
39. Elliott D.M., Yerramalli C.S., Beckstein J.C., Boxberger J.I., Johannessen W., Vresilovic E.J. The effect of relative needle diameter in puncture and sham injection animal models of degeneration. Spine 2008, 33(March):588-596.
40. Mizuno H., Roy A.K., Vacanti C.a., Kojima K., Ueda M., Bonassar L.J. Tissue-engineered composites of anulus fibrosus and nucleus pulposus for intervertebral disc replacement. Spine 2004, 29(June):1290-1297. [discussion 1297-1298].
41. Mizuno H., Roy A.K., Zaporojan V., Vacanti C.a., Ueda M., Bonassar L.J. Biomechanical and biochemical characterization of composite tissue-engineered intervertebral discs. Biomaterials 2006, 27(January):362-370.
42. Bowles R.D., Gebhard H.H., Härtl R., Bonassar L.J. Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine. Proc Natl Acad Sci U S A 2011, 108(August):13106-13111.
43. Bowles R.D., Gebhard H.H., Dyke J.P., Ballon D.J., Tomasino A., Cunningham M.E., Härtl R., Bonassar L.J. Image-based tissue engineering of a total intervertebral disc implant for restoration of function to the rat lumbar spine. NMR Biomed 2011, 25(March):443-451.
44. Bowles R.D., Williams R.M. Self-assembly of aligned tissue-engineered annulus fibrosus and intervertebral disc composite via collagen gel contraction. Tissue Eng A 2010, 16:1339-1348.
45. Park S.-H., Kaplan D.L. Intervertebral disk tissue engineering using biphasic silk composite scaffolds. Tissue Eng A 2012, 18:447-458.
46. Nesti L.J., Li W.-J., Shanti R.M., Jiang Y.J., Jackson W., Freedman B.a., Kuklo T.R., Giuliani J.R., Tuan R.S. Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam. Tissue Eng A 2008, 14(September):1527-1537.
47. Nerurkar N.L., Sen S., Huang A.H., Elliott D.M., Mauck R.L. Engineered disc-like angle-ply structures for intervertebral disc replacement. Spine 2010, 35(April):867-873.
48. Lazebnik M., Detamore M. Biomimetic method for combining the nucleus pulposus and annulus fibrosus for intervertebral disc tissue engineering. J Tissue Eng Regen Med 2011, 5:e179-e187.
49. Zhuang Y., Huang B., Li C.Q., Liu L.T., Pan Y., Zheng W.J., Luo G., Zhou Y. Construction of tissue-engineered composite intervertebral disc and preliminary morphological and biochemical evaluation. Biochem Biophys Res Commun 2011, 407(April):327-332.