Differential effects of exercise intensities in hippocampal BDNF, inflammatory cytokines and cell proliferation in rats during the postnatal brain development

Neuroscience Letters

Volumn 553, Issue , 2013, Pages 1-6

  de Almeida, Alexandre Aparecido ^a   Gomes da Silva, Sérgio ^a,b   Fernandes, Jansen ^a   Peixinho Pena, Luiz Fernando ^a   Scorza, Fulvio Alexandre ^a   Cavalheiro, Esper Abrão ^a   Arida, Ricardo Mario ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

Author keywords

Brain; Development; Exercise; Inflammation; Intensity; Plasticity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL DEGENERATION; CELL PROLIFERATION; CONTROLLED STUDY; DENTATE GYRUS; DEVELOPMENTAL STAGE; EXERCISE INTENSITY; GROUPS BY AGE; HIPPOCAMPUS; INFLAMMATION; MALE; NERVE CELL PLASTICITY; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; TREADMILL EXERCISE;

BRAIN; DEVELOPMENT; EXERCISE; INFLAMMATION; INTENSITY; PLASTICITY;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL PROLIFERATION; CYTOKINES; DENTATE GYRUS; HIPPOCAMPUS; MALE; NEURONS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; TIME FACTORS;

EID: 84884401671     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.08.015     Document Type: Article

References (25)

1. Andersen S.L. Trajectories of brain development: point of vulnerability or window of opportunity?. Neurosci. Biobehav. Rev. 2003, 27:3-18.
2. Bernd P. The role of neurotrophins during early development. Gene Expr. 2008, 14:241-250.
3. Buck S.M., Hillman C.H., Castelli D.M. The relation of aerobic fitness to stroop task performance in preadolescent children. Med. Sci. Sports Exerc. 2008, 40:166-172.
4. Chennaoui M., Drogou C., Gomez-Merino D. Effects of physical training on IL-1beta, IL-6 and IL-1ra concentrations in various brain areas of the rat. Eur. Cytokine Netw. 2008, 19:8-14.
5. Colbert L.H., Davis J.M., Essig D.A., Ghaffar A., Mayer E.P. Tissue expression and plasma concentrations of TNFalpha, IL-1beta, and IL-6 following treadmill exercise in mice. Int. J. Sports Med. 2001, 22:261-267.
6. Deverman B.E., Patterson P.H., Cytokines CNS development. Neuron 2009, 64:61-78.
7. Gomes da Silva S., Dona F., da Silva Fernandes M.J., Scorza F.A., Cavalheiro E.A., Arida R.M. Physical exercise during the adolescent period of life increases hippocampal parvalbumin expression. Brain Dev. 2010, 32:137-142.
8. Gomes da Silva S., Unsain N., Masco D.H., Toscano-Silva M., de Amorim H.A., Silva Araujo B.H., Simoes P.S., Naffah-Mazzacoratti Mda G., Mortara R.A., Scorza F.A., Cavalheiro E.A., Arida R.M. Early exercise promotes positive hippocampal plasticity and improves spatial memory in the adult life of rats. Hippocampus 2012, 22:347-358.
9. Gorski J.A., Balogh S.A., Wehner J.M., Jones K.R. Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience 2003, 121:341-354.
10. Hagberg H., Mallard C. Effect of inflammation on central nervous system development and vulnerability. Curr. Opin. Neurol. 2005, 18:117-123.
11. Hillman C.H., Pontifex M.B., Raine L.B., Castelli D.M., Hall E.E., Kramer A.F. The effect of acute treadmill walking on cognitive control and academic achievement in preadolescent children. Neuroscience 2009, 159:1044-1054.
12. Hopkins M.E., Nitecki R., Bucci D.J. Physical exercise during adolescence versus adulthood: differential effects on object recognition memory and brain-derived neurotrophic factor levels. Neuroscience 2011, 194:84-94.
13. Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 2001, 24:677-736.
14. Kim Y.P., Kim H., Shin M.S., Chang H.K., Jang M.H., Shin M.C., Lee S.J., Lee H.H., Yoon J.H., Jeong I.G., Kim C.J. Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats. Neurosci. Lett. 2004, 355:152-154.
15. Lou S.J., Liu J.Y., Chang H., Chen P.J. Hippocampal neurogenesis and gene expression depend on exercise intensity in juvenile rats. Brain Res. 2008, 1210:48-55.
16. Lynch A.M., Walsh C., Delaney A., Nolan Y., Campbell V.A., Lynch M.A. Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10 - a role for IL-1 beta?. J. Neurochem. 2004, 88:635-646.
17. Noga O., Peiser M., Altenahr M., Knieling H., Wanner R., Hanf G., Grosse R., Suttorp N. Differential activation of dendritic cells by nerve growth factor and brain-derived neurotrophic factor. Clin. Exp. Allergy 2007, 37:1701-1708.
18. O'Donnell E., Vereker E., Lynch M.A. Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms. Eur. J. Neurosci. 2000, 12:345-352.
19. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinate 1996, Academic Press, New York.
20. Schmued L.C., Hopkins K.J. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 2000, 874:123-130.
21. Scorza C.A., Araujo B.H., Arida R.M., Scorza F.A., Torres L.B., Amorim H.A., Cavalheiro E.A. Distinctive hippocampal CA2 subfield of the Amazon rodent Proechimys. Neuroscience 2010, 169:965-973.
22. Sibley B.A., Etnier J.L. The relationship between physical activity and cognition in children: a meta-analysis. Pediatr. Exerc. Sci. 2003, 15:243-256.
23. Spedding M., Gressens P. Neurotrophins and cytokines in neuronal plasticity. Novartis Found. Symp. 2008, 289:222-233. discussion 233-240.
24. Uysal N., Tugyan K., Kayatekin B.M., Acikgoz O., Bagriyanik H.A., Gonenc S., Ozdemir D., Aksu I., Topcu A., Semin I. The effects of regular aerobic exercise in adolescent period on hippocampal neuron density, apoptosis and spatial memory. Neurosci. Lett. 2005, 383:241-245.
25. van Praag H., Christie B.R., Sejnowski T.J., Gage F.H. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:13427-13431.