Leptospiral LruA is required for virulence and modulates an interaction with mammalian apolipoprotein AI

Infection and Immunity

Volumn 81, Issue 10, 2013, Pages 3872-3879

  Zhang, Kunkun ^a   Murray, Gerald L ^a   Seemann, Torsten ^a   Srikram, Amporn ^b,c   Bartpho, Thanatchaporn ^b   Sermswan, Rasana W ^b   Adler, Ben ^a   Hoke, David E ^a  

^a MONASH UNIVERSITY   (Australia)

^b KHON KAEN UNIVERSITY   (Thailand)

^c KASETSART UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; LIPOPROTEIN LRUA; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DELETION MUTANT; GENE EXPRESSION; HAMSTER MODEL; IN VITRO STUDY; LEPTOSPIROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TRANSPOSON; WILD TYPE;

ANIMALS; APOLIPOPROTEIN A-I; BACTERIAL PROTEINS; CHICK EMBRYO; CRICETINAE; GENOME, BACTERIAL; GUINEA PIGS; LEPTOSPIRA; LEPTOSPIROSIS; MUTATION; PROTEIN BINDING; VIRULENCE;

EID: 84884389045     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01195-12     Document Type: Article

References (45)

1. Adler B, de la Peñmoctezuma A. 2010. Leptospira and leptospirosis. Vet. Microbiol. 140:287-a 296.
2. Pinne M, Haake DA. 2009. A comprehensive approach to identification of surface-exposed, outer membrane-spanning proteins of Leptospira interrogans. PLoS One 4:e6071. doi:10.1371/journal.pone.0006071.
3. Zipfel PF, Wurzner R, Skerka C. 2007. Complement evasion of pathogens: common strategies are shared by diverse organisms. Mol. Immunol. 44:3850-3857.
4. Schwarz-Linek U, Hook M, Potts JR. 2004. The molecular basis of fibronectin-mediated bacterial adherence to host cells. Mol. Microbiol. 52:631-641.
5. Ristow P, Bourhy P, McBride FW, Figueira CP, Huerre M, Ave P, Girons IS, Ko AI, Picardeau M. 2007. The OmpA-like protein Loa22 is essential for leptospiral virulence. PLoS Pathog. 3:e97. doi:10.1371/journal.ppat.0030097.
6. Murray GL, Srikram A, Henry R, Hartskeerl RA, Sermswan RW, Adler B. 2010. Mutations affecting Leptospira interrogans lipopolysaccharide attenuate virulence. Mol. Microbiol. 78:701-709.
7. Murray GL, Srikram A, Henry R, Puapairoj A, Sermswan RW, Adler B. 2009. Leptospira interrogans requires heme oxygenase for disease pathogenesis. Microbes Infect. 11:311-314.
8. Lambert A, Picardeau M, Haake DA, Sermswan RW, Srikram A, Adler B, Murray GA. 2012. FlaA proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath. Infect. Immun. 80:2019-2025.
9. Liao S, Sun A, Ojcius DM, Wu S, Zhao J, Yan J. 2009. Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai. BMC Microbiol. 9:253. doi:10.1186/1471-2180-9-253.
10. Zhang L, Zhang C, Ojcius DM, Sun D, Zhao J, Lin X, Li L, Li L, Yan J. 2012. The mammalian cell entry (Mce) protein of pathogenic Leptospira species is responsible for RGD motif-dependent infection of cells and animals. Mol. Microbiol. 83:1006-1023.
11. Eshghi A, Lourdault K, Murray GL, Bartpho T, Sermswan RW, Picardeau M, Adler B, Snarr B, Zuerner RL, Cameron CE. 2012. Leptospira interrogans catalase is required for resistance to H2O2 and for virulence. Infect. Immun. 80:3892-3899.
12. Lourdault K, Cerqueira GM, Wunder EA, Jr, Picardeau M. 2011. Inactivation of clpB in the pathogen Leptospira interrogans reduces virulence and resistance to stress conditions. Infect. Immun. 79:3711-3717.
13. Bulach DM, Zuerner RL, Wilson P, Seemann T, McGrath A, Cullen PA, Davis J, Johnson M, Kuczek E, Alt DP, Peterson-Burch Coppel BRL, Rood JI, Davies JK, Adler B. 2006. Genome reduction in Leptospira borgpetersenii reflects limited transmission potential. Proc. Natl. Acad. Sci. U. S. A. 103:14560-14565.
14. Verma A, Artiushin S, Matsunaga J, Haake DA, Timoney JF. 2005. LruA and LruB, novel lipoproteins of pathogenic Leptospira interrogans associated with equine recurrent uveitis. Infect. Immun. 73:7259-7266.
15. Verma A, Rathinam SR, Priya CG, Muthukkaruppan VR, Stevenson B, Timoney JF. 2008. LruA and LruB antibodies in sera of humans with leptospiral uveitis. Clin. Vaccine Immunol. 15:1019-1023.
16. Verma A, Kumar P, Babb K, Timoney JF, Stevenson B. 2010. Crossreactivity of antibodies against leptospiral recurrent uveitis-associated proteinsAand B (LruA and LruB) with eye proteins. PLoS Negl. Trop. Dis. 4:e778. doi:10.1371/journal.pntd.0000778.
17. Johnson RC, Walby J, Henry RA, Auran NE. 1973. Cultivation of parasitic leptospires: effect of pyruvate. Appl. Microbiol. 26:118-119.
18. Bourhy P, Louvel H, Saint Girons I, Picardeau M. 2005. Random insertional mutagenesis of Leptospira interrogans, the agent of leptospirosis, using a mariner transposon. J. Bacteriol. 187:3255-3258.
19. Murray GL, Morel V, Cerqueira GM, Croda J, Srikram A, Henry R, Ko AI, Dellagostin OA, Bulach DM, Sermswan RW, Adler B, Picardeau M. 2009. Genome-wide transposon mutagenesis in pathogenic Leptospira species. Infect. Immun. 77:810-816.
20. Murray GL, Ellis KM, Lo M, Adler B. 2008. Leptospira interrogans requires a functional heme oxygenase to scavenge iron from hemoglobin. Microbes Infect. 10:791-797.
21. Matsunaga J, Barocchi MA, Croda J, Young TA, Sanchez Y, Siqueira I, Bolin CA, Reis MG, Riley LW, Haake DA, Ko AI. 2003. Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily. Mol. Microbiol. 49:929-945.
22. Imin N, Kerim T, Weinman JJ, Rolfe BG. 2001. Characterisation of rice anther proteins expressed at the young microspore stage. Proteomics 1:1149-1161.
23. Noor NM, Steer DL, Wheaton BJ, Ek CJ, Truettner JS, Dietrich WD, Dziegielewska KM, Richardson SJ, Smith AI, VandeBerg JL, Saunders NR. 2011. Age-dependent changes in the proteome following complete spinal cord transection in a postnatal South American opossum (Monodelphis domestica). PLoS One 6:e27465. doi:10.1371/journal.pone.0027465.
24. Rumble SM, Lacroute P, Dalca AV, Fiume M, Sidow A, Brudno M. 2009. SHRiMP: accurate mapping of short color-space reads. PLoS Comput. Biol. 5:e1000386. doi:10.1371/journal.pcbi.1000386.
25. Biedzka-Sarek M, Metso J, Kateifides A, Meri T, Jokiranta TS, Muszynski A, Radziejewska-Lebrecht J, Zannis V, Skurnik M, Jauhiainen M. 2011. Apolipoprotein A-I exerts bactericidal activity against Yersinia enterocolitica serotype O:3. J. Biol. Chem. 286:38211-38219.
26. Chiang SL, Rubin EJ. 2002. Construction of a mariner-based transposon for epitope-tagging and genomic targeting. Gene 296:179-185.
27. Picardeau M. 2008. Conjugative transfer between Escherichia coli and Leptospira spp. as a new genetic tool. Appl. Environ. Microbiol. 74:319-322.
28. Picardeau M, Bulach DM, Bouchier C, Zuerner RL, Zidane N, Wilson PJ, Creno S, Kuczek ES, Bommezzadri S, Davis JC, McGrath A, Johnson MJ, Boursaux-Eude C, Seemann T, Rouy Z, Coppel RL, Rood JI, Lajus A, Davies JK, Medigue C, Adler B. 2008. Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis. PLoS One 3:e1607. doi:10.1371/journal.pone.0001607.
29. Patarakul K, Lo M, Adler B. 2010. Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum. BMC Microbiol. 10:31. doi:10.1186/1471-2180-10-31.
30. Arinami T, Hirano T, Kobayashi K, Yamanouchi Y, Hamaguchi H. 1990. Assignment of the apolipoprotein A-I gene to 11q23 based on RFLP in a case with a partial deletion of chromosome 11, del(11)(q23.3-- - - qter). Hum. Genet. 85:39-40.
31. Breslow JL, Ross D, McPherson J, Williams H, Kurnit D, Nussbaum AL, Karathanasis SK, Zannis VI. 1982. Isolation and characterization of cDNA clones for human apolipoprotein A-I. Proc. Natl. Acad. Sci. U. S. A. 79:6861-6865.
32. Lewis GF, Rader DJ. 2005. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ. Res. 96:1221-1232.
33. Walldius G, Jungner I. 2006. The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy-a review of the evidence. J. Intern. Med. 259:493-519.
34. Rader DJ. 2006. Molecular regulation of HDL metabolism and function: implications for novel therapies. J. Clin. Invest. 116:3090-3100.
35. Marcovina S, Packard CJ. 2006. Measurement and meaning of apolipoprotein AI and apolipoprotein B plasma levels. J. Intern. Med. 259:437-446.
36. Levine DM, Parker TS, Donnelly TM, Walsh A, Rubin AL. 1993. In vivo protection against endotoxin by plasma high density lipoprotein. Proc. Natl. Acad. Sci. U. S. A. 90:12040-12044.
37. Parker TS, Levine DM, Chang JC, Laxer J, Coffin CC, Rubin AL. 1995. Reconstituted high-density lipoprotein neutralizes gram-negative bacterial lipopolysaccharides in human whole blood. Infect. Immun. 63:253-258.
38. Wu A, Hinds CJ, Thiemermann C. 2004. High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications. Shock 21:210-221.
39. Feingold KR, Grunfeld C. 2011. The role of HDL in innate immunity. J. Lipid Res. 52:1-3.
40. Grunfeld C, Marshall M, Shigenaga JK, Moser AH, Tobias P, Feingold KR. 1999. Lipoproteins inhibit macrophage activation by lipoteichoic acid. J. Lipid Res. 40:245-252.
41. Courtney HS, Zhang YM, Frank MW, Rock CO. 2006. Serum opacity factor, a streptococcal virulence factor that binds to apolipoproteins A-I and A-II and disrupts high density lipoprotein structure. J. Biol. Chem. 281:5515-5521.
42. Hasebe A, Pennock ND, Mu HH, Chan FV, Taylor ML, Cole BC. 2006. A microbial TLR2 agonist imparts macrophage-activating ability to apolipoprotein A-I. J. Immunol. 177:4826-4832.
43. Gazi IF, Apostolou FA, Liberopoulos EN, Filippatos TD, Tellis CC, Elisaf MS, Tselepis AD. 2011. Leptospirosis is associated with markedly increased triglycerides and small dense low-density lipoprotein and decreased high-density lipoprotein. Lipids 46:953-960.
44. Vanaja R, Ratnam S, Vijayalakshmi KP. 2001. Lipid metabolic changes in experimentally induced leptospiral infection with serovars australis, canicola and icterohaemorrhagiae. Indian J. Exp. Biol. 39:75-77.
45. Srivastava R, Ray S, Vaibhav V, Gollapalli K, Jhaveri T, Taur S, Dhali S, Gogtay N, Thatte U, Srikanth R, Srivastava S. 2012. Serum profiling of leptospirosis patients to investigate proteomic alterations. J. Proteomics 76:56-68.