Low-dose cyclophosphamide-induced acute hepatotoxicity

American Journal of Case Reports

Volumn 14, Issue , 2013, Pages 345-349

  Subramaniam, S Ravih ^a   Cader, Rizna Abdul ^a   Mohd, Rozita ^a   Yen, Kong Wei ^a   Ghafor, Halim Abdul ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA MEDICAL CENTER   (Malaysia)

Author keywords

Cyclophosphamide; Granulomatosis with polyangiitis; Hepatotoxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; CYCLOPHOSPHAMIDE; FUNGUS ANTIBODY; ITRACONAZOLE; METHYLPREDNISOLONE; NEUTROPHIL CYTOPLASMIC ANTIBODY; TUBERCULOSTATIC AGENT;

ACUTE CORONARY SYNDROME; ACUTE LIVER FAILURE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIBODY DETECTION; ARTICLE; ASTHMA; BRONCHIECTASIS; CANDIDA ALBICANS; CASE REPORT; CHINESE; COMPUTER ASSISTED TOMOGRAPHY; CONSTRUCTION WORK; DEATH; DIARRHEA; DISEASE SEVERITY; DRUG MEGADOSE; DRUG PULSE THERAPY; DRUG WITHDRAWAL; DYSPNEA; ECHOCARDIOGRAPHY; EPIGASTRIC PAIN; FEVER; GLOMERULONEPHRITIS; GRANULOMATOSIS; GRANULOMATOSIS WITH POLYANGIITIS; HEMODIALYSIS; HOSPITAL ACQUIRED PNEUMONIA; HUMAN; KIDNEY FAILURE; LABORATORY TEST; LEG PAIN; LIMB WEAKNESS; LIVER TOXICITY; LOW DRUG DOSE; LUNG LAVAGE; LUNG NODULE; LUNG TUBERCULOSIS; MALE; MITRAL VALVE REGURGITATION; MYCETOMA; NERVE ROOT COMPRESSION; PARESTHESIA; PHYSICAL EXAMINATION; PLASMAPHERESIS; POLYNEUROPATHY; POSTPRIMARY TUBERCULOSIS; RESPIRATORY TRACT INFECTION; SCLERITIS; SERODIAGNOSIS; SIDE EFFECT; SYSTOLIC HEART MURMUR; THORAX PAIN; TOXIC HEPATITIS; TRICUSPID VALVE REGURGITATION; TUBERCULOUS SPONDYLITIS; VASCULAR DISEASE; VASCULITIC RASH; WALKING DIFFICULTY;

EID: 84884386207     PISSN: None     EISSN: 19415923     Source Type: Journal    
DOI: 10.12659/AJCR.889401     Document Type: Article

References (16)

1. Ponticelli C, Passerini P: Alkylating agents and purine analogues in primary glomerulonephritis with nephrotic syndrome. Nephrol Dial Transplant, 1991; 6: 381-88
2. Mukhtyar C, Guillevin L, Cid MC et al., for the European Vasculitis Study Group: EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis, 2009; 68(3): 310-17
3. Haubitz M: Acute and Long term Toxicity of cyclophosphamide. Transplantationsmedizin, 2007
4. Cleland BD, Pokorny CS: Cyclophosphamide related hepatotoxicity, NZ J Med, 1993; 23: 408
5. Muratori L, Ferrari R, Muratori P et al: Acute icteric hepatitis induced by a short course of low-dose cyclophosphamide in a patient with lupus nephritis. Dig Dis Sci, 2005; 50(12): 2364-65
6. Fraiser LH, Kanekal S, Kehrer JP: Cyclophosphamide toxicity. Characterizing and avoiding the problem. Drugs, 1991; 42: 781-95
7. Turnbull J, Harper L: Adverse effects of therapy for ANCA-associated vasculitis. Best Pract Res Clin Rheumatol, 2009; 23(3): 391-401
8. Akay H, Akay T, Secilmis S et al: Hepatotoxicity after low dose cyclophosphamide therapy. South Med J, 2006; 99: 1399-400
9. Synder LS, Heigh RI, Anderson ML: Cyclophosphamide induced hepatotoxicity in a patient with Wegener's granulomatosis. Mayo Clin Proc, 1993; 68: 1203-4
10. Centers for Disease Control and Prevention: Update: fatal and severe liver injuries associated with rifampin and pyrazinamide for latent tuberculosis infection. MMWR Morb Mortal Wkly Rep, 2002; 51: 998-99
11. Denning DW, Lee JY, Hostetler JS et al: NIAID mycoses study group multicenter trial of oral itraconazole for invasive aspergillosis. Am J Med, 1994; 97: 135-44
12. Lisker-Melman M, Hoofnagle JH: Phenytoin hepatotoxicity masked by corticosteroids. Arch Intern Med, 1989; 149: 1196-97
13. Jonge ME, Huitema AD, Beijnen JH, Rodenhuis S: High exposures to bioactivated cyclophosphamide are related to the occurrence of veno-occlusive disease of the liver following high-dose chemotherapy. Br J Cancer, 2006; 94: 1226-30
14. McDonald GB, Slattery JT, Bouvier ME et al: Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation. Blood, 2003; 101: 2043-48
15. Martinez-Gabarron M, Enriquez R, Sirvent AE et al: Hepatotoxicity following cyclophosphamide treatment in a patient with MPO-ANCA vasculitis: Nefrologia, 2011; 31(4): 496-98
16. Pinto N, Ludeman SM, Dolan ME: Drug focus: Pharmacogenetic studies related to cyclophosphamide-based therapy. Pharmacogenomics, 2009; 10: 1897-903