Making a mountain out of a Molehill: NRAS, mosaicism, and large congenital nevi

Journal of Investigative Dermatology

Volumn 133, Issue 9, 2013, Pages 2127-2130

  Gerami, Pedram ^a   Paller, Amy S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANOCORTIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA;

BLADDER DYSFUNCTION; BLOOD BRAIN BARRIER; CELL AGING; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CHROMOSOME 8Q; CHROMOSOME ANALYSIS; CONGENITAL NEVUS; DNA DAMAGE; EMBRYO DEVELOPMENT; FUNCTIONAL DISEASE; GENE MUTATION; GENETIC ASSOCIATION; HEADACHE; HUMAN; HYDROCEPHALUS; INTRACRANIAL HYPERTENSION; KERATINOCYTE; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOCYTIC NEVUS; MELANOCYTOSIS; MELANOMA; MELANOSIS; MENINX; MOSAICISM; MUSCLE HYPOTONIA; NEUROGENIC BOWEL; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE C MYC; ONCOGENE N RAS; ONCOGENE RAS; PHENOTYPE; PHOTOSENSITIVITY; PIGMENTED NEVUS; PRIORITY JOURNAL; REVIEW; SEIZURE; VOMITING;

EID: 84884365535     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.146     Document Type: Note

References (10)

1. Alikhan A, Ibrahimi OA, Eisen DB (2012) Congenital melanocytic nevi: Where are we now? Part I. Clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocutaneous melanosis. J Am Acad Dermatol 67:495-17
2. Bastian BC, Xiong J, Frieden IJ et al. (2002) Genetic changes in neoplasms arising in congenital melanocytic nevi: Differences between nodular proliferations and melanomas. Am J Pathol 161:1163-9
3. Bett BJ (2006) Large or multiple congenital melanocytic nevi: Occurrence of neurocutaneous melanocytosis in 1008 persons. J Am Acad Dermatol 54:767-77
4. Hydbring P, Bahram F, Su Y et al. (2010) Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation. Proc Natl Acad Sci USA 107: 58-63
5. Ichii-Nakato N, Takata M, Takayanagi S et al. (2006) High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi. J Invest Dermatol 126:2111-8
6. Kelleher FC, McArthur GA (2012) Targeting NRAS in melanoma. Cancer J 18:132-6
7. Kinsler VA, Abu-Amero S, Budd P et al. (2012) Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: A role for MC1R in human fetal development. J Invest Dermatol 132:2026-32
8. Kinsler VA, Thomas AC, Ishida M et al. (2013) Multiple congenital melanocytic naevi and neurocutaneous melanosis are caused by post-zygotic mutations in codon 61 of NRAS. J Invest Dermatol 133:2229-36
9. Li A, Ma Y, Jin M et al. (2012) Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism. J Invest Dermatol 132:2610-21
10. Torrelo A, Baselga E, Nagore E et al. (2005) Delineation of the various shapes and patterns of nevi. Eur J Dermatol 15:439-50