Anti-inflammatory entrapment in polycaprolactone/silica hybrid material prepared by sol-gel route, characterization, bioactivity and in vitro release behavior

Journal of Applied Biomaterials and Functional Materials

Volumn 11, Issue 3, 2013, Pages 172-179

  Catauro, Michelina ^a   Bollino, Flavia ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Bioactivity; Drug delivery; Organic inorganic hybrid; Sol gel

Indexed keywords

ATOMIC FORCE MICROSCOPY; CONTROLLED DRUG DELIVERY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HYBRID MATERIALS; HYDROXYAPATITE; POLYCAPROLACTONE; SCANNING ELECTRON MICROSCOPY; SILICONES; SOL-GEL PROCESS; SOL-GELS; TARGETED DRUG DELIVERY; ULTRAVIOLET VISIBLE SPECTROSCOPY;

ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY AGENTS; DRUG-DELIVERY SYSTEMS; HYBRIDS MATERIAL; ORGANIC-INORGANIC HYBRID MATERIALS; ORGANIC/INORGANIC HYBRIDS; SILICA HYBRIDS; SIMULATED BODY FLUIDS; SOL'GEL; SYNTHESISED;

SILICA;

INDOMETACIN; POLYCAPROLACTONE; SILICON DIOXIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATOMIC FORCE MICROSCOPY; BODY FLUID; CRYSTALLIZATION; DRUG STRUCTURE; ENZYME KINETICS; HYDROGEN BOND; INFRARED SPECTROSCOPY; MICELLE; PHASE SEPARATION; ULTRAVIOLET SPECTROSCOPY;

ANTI-INFLAMMATORY AGENTS; DRUG CARRIERS; GELS; INDOMETHACIN; KINETICS; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING; POLYESTERS; SILICON DIOXIDE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84884335562     PISSN: None     EISSN: 22808000     Source Type: Journal    
DOI: 10.5301/JABFM.2012.9256     Document Type: Article

References (45)

1. Vallet-Regí M. Ceramics for medical applications. Journal of the Chemical Society, Dalton Transactions 2001; 2: 97-108.
2. Vallet-Regí M, Arcos D. Nanostructured hybrid materials for bone tissue regeneration. Curr Nanosci 2006; 2: 179-89.
3. Vallet-Regí M. Ordered mesoporous materials in the context of drug delivery systems and bone tissue engineering. Chemistry A European Journal 2006; 12: 5934-43.
4. Vallet-Regí M. Bone repair and regeneration: possibilities. Materwiss Werksttech 2006; 37: 478-84.
5. Black J, Hastings G eds. Handbook of biomaterial properties. New York: Chapman & Hall 1998.
6. Vallet-Regi M, Ramila A, del Real RP, Perez-Pariente J. A new property of MCM-41: drug delivery system. Chem Mater 2000; 13: 308-11.
7. Ragel CV, Vallet-Regí M. In vitro bioactivity and gentamicin release from glass-polymer-antibiotic composites. J Biomed Mater Res 2000; 51: 424-29.
8. Arcos D, Ragel CV, Vallet-Regí M. Bioactivity in glass/PMMA composites used as drug delivery system. Biomaterials 2001; 22: 701-08.
9. Judeinstein P, Sanchez C. Hybrid organic-inorganic materials: a land of multidisciplinarity. J Mater Chem 1996; 6: 511-25
10. Hench LL, West JK. The sol-gel process. Chem Rev 1990; 90: 33-72.
11. Novak BM. Hybrid nanocomposite materials between inorganic glasses and organic polymers. Adv Mater 1993; 5: 422-33
12. Hsiue GH, Kuo JK, Jeng RJ, et al. Stable second-order non linear optical polymer network based on an organosoluble polyimide. Chem Mater 1994; 6: 884-7.
13. Wei Y, Xu J, Dong H, Dong JH, Qiu K, Jansen-Varnum SA. Preparation and physisorption characterization of d-glucose-templated mesoporous silica sol-gel materials. Chem Mater 1999; 11: 2023-9.
14. Klein CPAT eds. Sol-gel technology for thin films, fibers, preforms, electronics and specialty shapes. Park Ridge, N.J., U.S.A. Noyes Publications 1988.
15. Brinker CJ, Scherer GW eds. Sol-gel science, the physics and chemistry of sol-gel processing. San Diego: Academic Press 1989.
16. Wei Y, Bakthavatchalam R, Whitecar CK. Synthesis of new organic-inorganic hybrid glasses. Chem Mater 1990; 2: 337-9.
17. Wei Y, Dachuan Y, Bakthavatchalam R. Thermal stability and hardness of new polyacrylate-SiO2 hybrid sol-gel materials. Mater Lett 1992; 13: 261-6.
18. Hay JN, Raval HM. Synthesis of organic-inorganic hybrids via the non-hydrolytic sol-gel process. Chem Mater 2001; 13: 3396-403.
19. Gao Y, Choudhury NR, Dutta N, Matisons J, Reading M, Delmotte L. Organic-inorganic hybrid from ionomer via sol-gel reaction. Chem Mater 2001; 13: 3644-52.
20. David IA, Scherer GW. An organic/inorganic single-phase composite. Chem Mater 1995; 7: 1957-67.
21. Fitzgerald JJ, Landry CJT, Pochan JM. Dynamic studies of the molecular relaxations and interactions in microcosm posites prepared by in-situ polymerization of silicon alkoxides. Macromolecules 1992; 25: 3715-22.
22. Saegusa T. Organic/inorganic polymer hybrids. Macromol Symp 1995; 98: 719-29.
23. Klein LL, Sanchez C. Hybrid organic-inorganic materials. J Sol-Gel Sci Technol 1995; 5: 75-157.
24. Sanchez C, Ribot F. Design of hybrid organic-inorganic materials synthesized via sol-gel chemistry. New J Chem 1994; 18: 1007-47.
25. Young SK, Gemeinhardt GC, Sherman JW, et al. Covalent and non-covalently coupled polyester-inorganic composite materials. Polymer 2002; 43: 6101-14.
26. Kokubo T, Kim H-M, Kawashita M, Nakamura T. Process of calcification on artificial materials. Z. Kardiol. 2001; 90: iii/86-iii/91.
27. Ohtsuki C, Kokubo T, Yamamuro T. Mechanism of apatite formation on CaO • SiO2 • P 2O5 glasses in a simulated body fluid. J Non-Crys Solids 1992; 143: 84-92.
28. Hutmacher DW, Schantz T, Zein I, Woei Ng K, Hin Teoh S, Cheng Tan K. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res 2001; 55: 203-16.
29. Khor HL, Ng KW, Schantz JT, et al. Poly(e-caprolactone) films as a potential substrate for tissue engineering an epidermal equivalent. Mat Sci Eng C 2002; 20: 71-5.
30. Allen C, Han J, Yu Y, Maysinger D, Eisenberg A. Polycaprolactoneb-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone. J Control Release 2000; 63: 275-86.
31. Chen B, Evans JRG. Poly(e-caprolactone)-clay nanocomposites: structure and mechanical properties. Macromolecules 2005; 39: 747-54.
32. Messersmith PB, Giannelis EP. Polymer-layered silicate nanocomposites: in situ intercalative polymerization of e-caprolactone in layered silicates. Chem Mater 1993; 5: 1064-6.
33. Nie K, Pang W, Wang Y, Lu F, Zhu Q. Effects of specific bonding interactions in poly(e-caprolactone)/silica hybrid materials on optical transparency and melting behavior. Mater Lett 2005; 59: 1325-8.
34. Wu C-S. In situ polymerization of titanium isopropoxide in polycaprolactone: Properties and characterization of the hybrid nanocomposites. J Appl Polym Sci 2004; 92: 1749-57.
35. Catauro M, Raucci MG, De Gaetano F, Marotta A. Sol-gel synthesis, characterization and bioactivity of polycaprolactone/SiO2 hybrid material. J Mater Sci 2003; 38: 3097-102.
36. Catauro M, Raucci MG, de Gaetano F, Buri A, Marotta A, Ambrosio L. Sol-gel synthesis, structure and bioactivity of polycaprolactone/CaO • SiO2 hybrid material. J Mater Sci Mater Med 2004; 15: 991-5.
37. De Gaetano F, Ambrosio L, Raucci MG, Marotta A, Catauro M. Sol-gel processing of drug delivery materials and release kinetics. J Mater Sci Mater Med 2005; 16: 261-5.
38. Catauro M, Raucci MG, Marco Dd, Ambrosio L. Release kinetics of ampicillin, characterization and bioactivity of TiO2/ PCL hybrid materials synthesized by sol-gel processing. J Biomed Mater Res A 2006; 77A: 340-50.
39. Catauro M, Raucci M, Ausanio G. Sol-gel processing of drug delivery zirconia/polycaprolactone hybrid materials. J Mater Sci Mater Med 2008; 19: 531-40.
40. De Santis R, Catauro M, Di Silvio L, et al. Effects of polymer amount and processing conditions on the in vitro behavior of hybrid titanium dioxide/polycaprolactone composites. Biomaterials 2007; 28: 2801-09.
41. Teoli D, Parisi L, Realdon N, Guglielmi M, Rosato A, Morpurgo M. Wet sol-gel derived silica for controlled release of proteins. J Control Release 2006; 116: 295-303.
42. Hench LL, Clark DE. Physical chemistry of glass surfaces. J Non Cryst Solids 1978; 28: 83-105.
43. Paul A eds. Chemistry of glasses. New York: Chapman and Hall 1990; 184.
44. Wang DS, Pantano CG. Surface chemistry of multicomponent silicate gels. J Non Cryst Solids 1992; 147-148: 115-22.
45. Sanchez C, Livage J, Henry M, Babonneau F. Chemical modification of alkoxide precursors. J Non Cryst Solids 1988; 100: 65-76.