Impact of Pongamia Pinnata extract on lead acetate mediated toxicity in rat liver

International Journal of PharmTech Research

Volumn 4, Issue 2, 2012, Pages 878-882

  Anuradha, R ^a   Krishnamoorthy, Palaniyandi ^b  

^a STET Women's College   (India)

^b Rajah Serfoji Govt College(Auto)   (India)

Author keywords

Carvedilol; Hepatic markers; Lead acetate; Liver; Methanol; Pongamia pinnata

Indexed keywords

ASTRAGALIN; CARVEDILOL; LEAD ACETATE; PLANT EXTRACT; PONGAMIA PINNATA EXTRACT; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; FLOWER; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; LIVER TOXICITY; MALE; NONHUMAN; PONGAMIA PINNATA; PROTEIN BLOOD LEVEL; RAT;

EID: 84884323174     PISSN: 09744304     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Patrick, L. 2002. Mercury toxicity and antioxidants. Part I: Role of glutathione and alphalipoic acid in the treatment of mercury toxicity. Altern. Med. Rev., 7: 456-471.
2. Sharma, R.K. and Agarwal, M. 2005. Biological effects of heavy metals; an overview. J. Environ. Biol., 26: 301-313.
3. Ceribasi, I. H. and Yetis, U. 2001. Biosorption of Ni (ii) and Pb (ii) by Phanaerochaete chrysosporium from a binary metal systemkinetics, Water SA, 24: 1-15.
4. Hernandez-Munoz, R., Diaz-Munoz, M. and Sanchez, V. C. 1992. Effects of adenosine administration on the function and membrane composition of liver mitochondria in carbon tetrachloride-induced cirrhosis. Arch. Biochem. Biophys., 294: 160-7.
5. Tyagi, P., Buddhi, D., Chodhary, R. and Sawheny, R.L. 1999. Degradation of ground water quality due to heavy metals in industrial areas of India- A review. IJEP, 20:174-179.
6. Mudakavi, J. P. and Narayana, B. V. 1997. Toxic heavy metal contamination of the soil and biota: Part II-Environmental implications, IJEP, 18:108-116.
7. Eisler, R. 2000. Nickel hazards to fish wild life and invertebrates: A synoptic review, in Contaminant hazard reviews, 1-35, Patuxtent Wild life Research Centre, Laurel, Maryland, P. 1.
8. Colbourn, P. and Thronton R. 1978. Lead pollution in agricultural soils, J. Soil Sci., 29: 513-517.
9. Neugebauer, G., Akpan, W., Kaufmann, B. and Reiff, K. 1990. Stereoselective disposition of carvedilol in man after intravenous and oral administration of the racemic compound. Eur. J. Clin. Pharmacol., 38: S108-S111.
10. Fujimaki, M., Murakoshi, Y. and Hakusui, H. 1990. Assay and disposition of carvedilil enantiomers in humans and monkeys: evidence of stereoselective presystemic metabolism. J. Pharm. Sci., 79: 568-572.
11. Fujimaki, M. and Hakusui, H. 1989. Studies on the metabolic fate of carvedilol. III. Biliary excretion and enterohepatic circulation in rats. Yakubutsu Dotai, 4: 667-671.
12. Fujimaki, M. and Hakusui, H. 1990. Identification of two major biliary metabolites of carvedilol in rats. Xenobiotica, 20: 1025-1034.
13. Fujimaki, M., Shintani, S. and Hakusui, H. 1991. Steroselective metabolism of carvedilol in the rat: use of enantiomerically radiolabeled pseudoracemates. Drug Metab. Dispos., 19: 749-753.
14. Krishnamurthi, A. 1969. The Wealth of India, vol. VIII. Publication and Information Directorate CSIR, New Delhi, India.
15. Punitha, R. and Manoharan, S. 2006. Antihyperglycemic and antilipideroxidative effects of Pongamia pinnata (Linn.) Pierre flowers in alloxan induced diabtetic rats. J. Ethnopharmacol., 105: 39-46.
16. Sarma, A. K., Konwer, D. and Bordoloi, P. K. 2005. A comprehensive analysis of fuel properties of biodiesel from Koroch seed oil. Energy Fuels, 19: 656-657.
17. Meera, B., Kumar, S. and Kalidhar, S. B. 2003. A review of the chemistry and biological activity of Pongamia pinnata. J. Medicinal Aromatic Plant Sci., 25: 441-465.
18. Shoba, G. F. and Thomas, M. 2001. Study of antidiarrhoel activity of four medicinal plants in castor-oil induced diarrhea. J. Enthnopharmacol., 76: 73-76.
19. Brijesh, S., Daswani, P.G., Tetali, P., Rojatkar, S.R., Antia, N.H. and Birdi, T.J. 2006. Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea. J. Zhejiang Univ. Sci., 7: 665-674.
20. Banu, R., Sharma, R. and Quershi, N. 2006. Protection of lead-induced renal toxicity by antioxidant vitamins C and E, Adv. Pharmacol. Toxicol., 7: 37-46.
21. Reitman, S., Frankel, S. 1934. A colorimetric method for the determination of serum glutamic oxloacetate acid and glutamic pyruvate transaminases. Am. J., 31: 56-63.
22. King, E. J. and Armstrong, A. R. 1934. Determination of serum and bile phosphatase activity. Can. Med. Assoc. J., 31: 56-63.
23. Rosalki, S.B. and Rau, D. 1972. Serum gammaglutamyl transpeptidase activity in alcoholism. Clin. Chem. Acta., 39: 41-47.
24. Lowry, O. H., Roseborough, N. J., Farr, A. L. and Randal, R. J. 1951. Protein measurement with Folin's phenol reagent. J. Biol. Chem., 193: 265-275.
25. Malloy, H. T. and Evelyn, K. A. 1937. The determination of bilirubin with the photoelectric colorimeter. J. Biol. Chem., 119: 481-490.
26. Mitra, S.K., Venkataranganna, M.V., Sundaram, R. and Gopumadhavan, S. 1998. Protective effect of HD - 03, a herbal formulation against various hepatotoxic agents in rats. J. Ethanopharmacol., 63: 181-186.
27. Talmage, R.V., Vander Wiel, C.J., Norimatsu, H. 1978. A reevaluation of the cause of acute hypercalcemia following intravenous administration of lead acetate. Calcif. Tiss. Res., 26: 149-153.
28. Hassanin, L.A.M. 1994. The effect of lead pollution on the susceptibility of rats to anticoagulants rodenticides, M.Sc., Thesis, Zoology Department, Faculty of Science, Cairo University, Giza, Egypt. P.123.
29. Shalan, M. A., Mostafa, M. S., Hassouna, M. M., El-Nabi, S. E. and El-Refale, A. 2005. Amelioration of lead toxicity on rat liver with vitamin C and silymarin supplements. Toxicol., 206: 1-15.
30. Latner, A.L. 1975. In: Contarow, Tramper (Eds.), Clinical Biochemistry. Sunders, Philadelphia. P.23.
31. Georing, P.L. 1993. Lead-protein interaction as a basis for lead toxicity, Neurotoxicol., 14: 45-60.
32. El-Zayat, E.M., El-Ymany, N.A., Kamel, Z.H. 1996. Combined supplementation of zinc and vitamin C as protective agents against lead toxicity in growing male albino rats. Liver functions, J. Egypt Ger. Soc. Zool., 20: 115-139.
33. Harper, H.A. 1961. The functions and tests of the liver. In: Review of physiological chemistry. Lange Medical Publishers, Los Atlos, California, P. 271-283.