Importance of particle size and shape on the tensile strength distribution and de-agglomeration of cohesive powders

Powder Technology

Volumn 249, Issue , 2013, Pages 297-303

  Das, Shyamal C ^a,b   Behara, Srinivas Ravindra Babu ^a   Morton, David A V ^a   Larson, Ian ^a   Stewart, Peter J ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Agglomerate strength; De agglomeration; Dry powder inhaler; Intermediate lactose; Shape; Size

Indexed keywords

AGGLOMERATE STRENGTH; DE AGGLOMERATIONS; DRY POWDER INHALER; INTERMEDIATE LACTOSE; SHAPE; SIZE;

ADHESION; AIR; DIFFRACTION; FLOW RATE; GAS CHROMATOGRAPHY; MONTE CARLO METHODS; PARTICLE SIZE; POWDERS; SCANNING ELECTRON MICROSCOPY; SIZE DISTRIBUTION; STRENGTH OF MATERIALS; SUGARS; TENSILE STRENGTH;

AGGLOMERATION;

LACTOHALE 201; LACTOHALE 210; LACTOHALE 220; LACTOSE; UNCLASSIFIED DRUG;

AIRFLOW; ARTICLE; CHEMICAL STRUCTURE; COHESION; COHESIVE POWDER; CONTROLLED STUDY; DE AGGLOMERATION; DENSITY; FLOW RATE; INVERSE GAS CHROMATOGRAPHY; LASER DIFFRACTION; MONTE CARLO METHOD; PARTICLE SIZE; PHYSICAL PARAMETERS; PHYSICAL PHENOMENA; PLUME; POWDER; SCANNING ELECTRON MICROSCOPY; TENSILE STRENGTH;

EID: 84884314480     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2013.08.034     Document Type: Article

References (40)

1. Adi H., Larson I., Stewart P.J. Adhesion and redistribution of salmeterol xinafoate particles in sugar-based mixtures for inhalation. Int. J. Pharm. 2007, 337:229-238.
2. Qui Y., Adjei A.L., Gupta P.K. Absorption and bioavailability of inhaled peptides and proteins. Inhalation delivery of Therapeutic Peptides and Proteins 1997, Mercel Dekker, Inc., New york. A.L. Adjei, P.K. Gupta (Eds.).
3. Adi H., Larson I., Chiou H., Young P., Traini D., Stewart P. Agglomerate strength and dispersion of salmeterol xinafoate from powder mixtures for inhalation. Pharm. Res. 2006, 23:2556-2565.
4. Das S., Larson I., Young P., Stewart P. Influence of storage relative humidity on the dispersion of salmeterol xinafoate powders for inhalation. J. Pharm. Sci. 2009, 98:1015-1027.
5. Adi S., Adi H., Chan H.-K., Finlay W.H., Tong Z., Yang R., Yu A. Agglomerate strength and dispersion of pharmaceutical powders. J. Aerosol Sci. 2011, 42:285-294.
6. Kendall K., Stainton C. Adhesion and aggregation of fine particles. Powder Technol. 2001, 121:223-229.
7. Das S., Behara S., Bulitta J., Morton D., Larson I., Stewart P. Powder strength distributions for understanding de-agglomeration of lactose powders. Pharm. Res. 2012, 29:2926-2935.
8. Das S.C., Behara S.R., Morton D.A.V., Larson I., Stewart P. Superiority of powder strength distribution for understanding de-agglomeration of lactose powders. Respiratory Drug Delivery 2012, 585-590. Davis Healthcare International publishing, LLC, Arizona. R. Dalby, P. Byron, J. Peart, J. Suman, S. Farr, P. Young (Eds.).
9. Brouwers H.J.H. Particle-size distribution and packing fraction of geometric random packings. Phys. Rev. E 2006, 74.
10. Sohn H.Y., Moreland C. Effect of particle size distribution on packing density. Can. J. Chem. Eng. 1968, 46:162-167.
11. Steckel H., Muller B.W. In vitro evaluation of dry powder inhalers.2. Influence of carrier particle size and concentration on in vitro deposition. Int. J. Pharm. 1997, 154:31-37.
12. Donovan M.J., Smyth H.D.C. Influence of size and surface roughness of large lactose carrier particles in dry powder inhaler formulations. Int. J. Pharm. 2010, 402:1-9.
13. Islam N., Stewart P., Larson I., Hartley P. Effect of carrier size on the dispersion of salmeterol xinafoate from interactive mixtures. J. Pharm. Sci. 2004, 93:1030-1038.
14. Ooi J., Traini D., Hoe S., Wong W., Young P.M. Does carrier size matter? A fundamental study of drug aerosolisation from carrier based dry powder inhalation systems. Int. J. Pharm. 2011, 413:1-9.
15. Zeng X.M., Martin G.P., Tee S.K., Marriott C. The role of fine particle lactose on the dispersion and deaggregation of salbutamol sulphate in an air stream in vitro. Int. J. Pharm. 1998, 176:99-110.
16. Lucas P., Anderson K., Staniforth J.N. Protein deposition from dry powder inhalers: fine particle multiplets as performance modifiers. Pharm. Res. 1998, 15:562-569.
17. Louey M.D., Stewart P.J. Particle interactions involved in aerosol dispersion of ternary interactive mixtures. Pharm. Res. 2002, 19:1524-1531.
18. Ulusoy U., Kursun I. Comparison of different 2D image analysis measurement techniques for the shape of talc particles produced by different media milling. Miner. Eng. 2011, 24:91-97.
19. Zeng X.M., Martin G.P., Marriott C., Pritchard J. The influence of carrier morphology on drug delivery by dry powder inhalers. Int. J. Pharm. 2000, 200:93-106.
20. Alway B., Sangchantra R., Stewart P.J. Modelling the dissolution of diazepam in lactose interactive mixtures. Int. J. Pharm. 1996, 130:213-224.
21. Das S.C., Larson I., Morton D.A.V., Stewart P.J. Determination of the polar and total surface energy distributions of particulates by inverse gas chromatography. Langmuir 2011, 27:521-523.
22. Das S.C., Zhou Q., Morton D.A.V., Larson I., Stewart P.J. Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. Eur. J. Pharm. Sci. 2011, 43:325-333.
23. Schultz J., Lavielle L., Martin C. The role of the interface in carbon-fiber epoxy composites. J. Adhes. 1987, 23:45-60.
24. Thielmann F., Naderi M., Burnett D., Jervis H. Investigation of the acid-base properties of an MCM-supported ruthenium oxide catalyst by inverse gas chromatography and dynamic vapour sorption. Catalysis in application, Royal Soc. Chem. Great Britain 2003, 237. S. Jackson, J. Hargreaves, D. Lennon (Eds.).
25. Traini D., Young P.M., Thielmann F., Acharya M. The influence of lactose pseudopolymorphic form on salbutamol sulfate-lactose interactions in DPI formulations. Drug Dev. Ind. Pharm. 2008, 34:992-1001.
26. Grimsey I.M., Feeley J.C., York P. Analysis of the surface energy of pharmaceutical powders by inverse gas chromatography. J. Pharm. Sci. 2002, 91:571-583.
27. Vanoss C.J., Good R.J., Chaudhury M.K. Additive and nonadditive surface tension components and the interpretation of contact angles. Langmuir 1988, 4:884-891.
28. Rowe R., Sheskey P., Quinn M. Handbook of Pharmaceutical Excipients 2009, Pharmaceutical Press, London. 6th ed.
29. Coady T.J., Davies H.J., Barnes P. Evaluation of a breath actuated pressurized aerosol. Clin. Allergy 1976, 6:1-6.
30. Sarinas P.S.A., Robinson T.E., Clark A.R., Canfield J., Chitkara R.K., Fick R.B. Inspiratory flow rate and dynamic lung function in cystic fibrosis and chronic obstructive lung diseases. Chest 1998, 114:988-992.
31. Wijkstra P.J., Vandermark T.W., Boezen M., Vanaltena R., Postma D.S., Koeter G.H. Peak inspiratory mouth pressure in healthy-subjects and in patients with COPD. Chest 1995, 107:652-656.
32. Behara S.R.B., Kippax P., McIntosh M.P., Morton D.A.V., Larson I., Stewart P. Structural influence of cohesive mixtures of salbutamol sulphate and lactose on aerosolisation and de-agglomeration behaviour under dynamic conditions. Eur. J. Pharm. Sci. 2011, 42:210-219.
33. Behara S.R.B., Larson I., Kippax P., Morton D.A.V., Stewart P. An approach to characterising the cohesive behaviour of powders using a flow titration aerosolisation based methodology. Chem. Eng. Sci. 2011, 66:1640-1648.
34. Ho R., Hinder S.J., Watts J.F., Dilworth S.E., Williams D.R., Heng J.Y.Y. Determination of surface heterogeneity of D-mannitol by sessile drop contact angle and finite concentration inverse gas chromatography. Int. J. Pharm. 2010, 387:79-86.
35. Marquardt D. An algorithm for least-squares estimation of nonlinear parameters. J. Soc. Ind. Appl. Math. 1963, 11:431-441.
36. Draper N., Smith H. Applied Regression Analysis 1981, John wiley and Sons, New York.
37. Jones M.D., Price R. The influence of fine excipient particles on the performance of carrier-based dry powder inhalation formulations. Pharm. Res. 2006, 23:1665-1674.
38. Hiçyilmaz, Ulusoy U., Yekeler M. Effect of shape properties of talc and quartz particles on the wettability based separation processes. Appl. Surf. Sci. 2004, 233:204-212.
39. Stojmenović M., Žunić J. Measuring elongation from shape boundary. J. Math. Imaging Vis. 2008, 30:73-85.
40. Yekeler M., Ulusoy U., Hiçyilmaz C. Effect of particle shape and roughness of talc mineral ground by different mills on the wettability and floatability. Powder Technol. 2004, 68-78.