Optimization of radiosynthesis of molecular tracers in EWOD microfluidic chip

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

Volumn 1, Issue , 2010, Pages 668-670

  Keng, Pei Yuin ^a,b   Chen, Supin ^b   Ding, Hui Jiang ^a,b   Sadeghi, Sam ^a,b   Phelps, Michael E ^a,b   Satyamurthy, Nagichettiar ^a,b   Kim, Chang Jin ^b   Van Dam, R Michael ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Digital microfluidics; Electrowetting on dielectric (EWOD); Molecular tracers; Positron emission tomography (PET); Radiosynthesis

Indexed keywords

ELECTROWETTING ON DIELECTRICS; MICROFLUIDIC CHIP; MOLECULAR PROBES; MOLECULAR TRACER; OPTIMIZATION STUDIES; POSITRON EMISSION TOMOGRAPHY (PET); RADIOSYNTHESIS; REACTION CONDITIONS;

DIELECTRIC MATERIALS; DIGITAL MICROFLUIDICS; OPTIMIZATION; POSITRON EMISSION TOMOGRAPHY; WETTING;

DIELECTRIC DEVICES;

EID: 84884296500     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (10)

1. M. E. Phelps, "Positron Emission Tomography Provides Molecular Imaging of Biological Processess", Proc Natl Acad Sci 97, 9226 (2000).
2. A. M. Elizarov, "Microreactors for Radiopharmaceutical Synthesis", Lab Chip 9, 1326 (2009).
3. P. W. Miller, "Radiolabelling with Short-Lived Pet (Positron Emission Tomography) Isotopes Using Microfluidic Reactors", J Chem Technol Biotechnol 84, 309 (2009).
4. C.-C. Lee, G. Sui, A. Elizarov, C. Y. J. Shu, Y.-S. Shin, A. N. Dooley, J. Huang, A. Daridon, P. Wyatt, D. Stout, H. C. Kolb, O. N. Witte, N. Satyamurthy, J. R. Heath, M. E. Phelps, S. R. Quake, H.-R. Tseng, "Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics", Science 310, 1793 (2005).
5. J. N. Lee, C. Park, G. M. Whitesides, "Solvent Compatibility of Poly(Dimethylsiloxane)-Based Microfluidic Devices", Anal. Chem. 75, 6544 (2003).
6. R. B. Fair, "Digital Microfluidics: Is a True Lab-on-a-Chip Possible?" Microfluid. Nanofluid. 3, 245 (2007).
7. J. Lee, C.-J. Kim, "Surface-Tension-Driven Microactuation Based on Continuous Electrowetting", J. Microelectromech. Syst, 9, 171 (2000).
8. M. G. Pollack, R. B. Fair, "Electrowetting-Based Actuation of Liquid Droplets for Microfluidic Applications", Appl. Phys. Lett. 77, 1725 (2000).
9. S. Chen, H. Ding, G. J. Shah, R. M. van Dam, C.-J. Kim, in Technical Digest of Solid-State Sensors and Actuators Workshop. (Hilton Head Island, June 2010).
10. 18f]Fluor-2-Deoxy-D-Glucose Involving Base Hydrolysis", Radiochem 44, 403 (2002).