Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1

Biochemical and Biophysical Research Communications

Volumn 439, Issue 2, 2013, Pages 235-240

  Liu, Qi Feng ^a   Yu, Hong Wei ^b   You, Lu ^a   Liu, Ming Xin ^a   Li, Ke Yan ^a,b   Tao, Gui Zhou ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

^b Jinzhou Central Hospital   (China)

Author keywords

Apelin 13; Early growth response factor 1; Migration; Osteopontin; Proliferation; Vascular smooth muscle cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; APELIN; APELIN 13; DEOXYRIBOZYME; EARLY GROWTH RESPONSE FACTOR 1; MESSENGER RNA; OSTEOPONTIN; UNCLASSIFIED DRUG;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

APELIN-13; EARLY GROWTH RESPONSE FACTOR-1; MIGRATION; OSTEOPONTIN; PROLIFERATION; VASCULAR SMOOTH MUSCLE CELLS;

ANIMALS; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; EARLY GROWTH RESPONSE PROTEIN 1; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MYOCYTES, SMOOTH MUSCLE; OSTEOPONTIN; RATS; UP-REGULATION;

RATTUS;

EID: 84884292464     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.08.051     Document Type: Article

References (19)

1. Li G., Chen S.J., Oparil S., Chen Y.F., Thompson J.A. Direct in vivo evidence demonstrating neointimal migration of adventitial fibroblasts after balloon injury of rat carotid arteries. Circulation 2000, 101:1362-1365.
2. Schwartz R.S., Henry T.D. Pathophysiology of coronary artery restenosis. Rev. Cardiovasc. Med. 2002, 3:4-9.
3. Xu Y., Arai H., Murayama T., Kita T., Yokode M. Hypercholesterolemia contributes to the development of atherosclerosis and vascular remodeling by recruiting bone marrow-derived cells in cuff-induced vascular injury. Biochem. Biophys. Res. Commun. 2007, 363:782-787.
4. Barnes G., Japp A.G., Newby D.E. Translational promise of the apelin-APJ system. Heart 2010, 10:11-16.
5. Fukushima H., Kobayashi N., Takeshima H., Koguchi W., Ishimitsu T. Effects of olmesartan on Apelin/APJ and Akt/endothelial nitric oxide synthase pathway in Dahl rats with end-stage heart failure. J. Cardiovasc. Pharmacol. 2010, 55:83-88.
6. Luan R.H., Jia G.L., Li W., Jia Z.S., Lian J.Q. Inhibition of vascular smooth muscle cell proliferation by specific c-myc mRNA cleaving hammerhead ribozyme. J. Fourth Mil. Med. Univ. 2003, 24:517-521.
7. Thiel G., Cibelli G. Regulation of life and death by the zinc finger transcription factor Egr-1. J. Cell Physiol. 2002, 193:287-292.
8. Khachigian L.M. Early growth response-1 in cardiovascular pathobiology. Circ. Res. 2006, 98:186-191.
9. Mao X.H., Li L.F., Gao J., Yang L., Liu W., Qin X.P., Chen L.X. Apelin-13 promotes proliferation of vascular smooth muscle cells by downregulating caveolae expression. J. Clin. Rehabil. Tissue Eng. Res. 2011, 15:8603-8608.
10. Eyries M., Siegfried G., Ciumas M., Montagne K., Agrapart M., Lebrin F., Soubrier F. Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis. Circ. Res. 2008, 103:432-440.
11. Zhao T., Lu Q., Tao Y., Liang X.Y., Wang K., Jiang Y.R. Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study. Mol. Vis. 2011, 17:1044-1055.
12. Sakimoto S., Kidoya H., Naito H., Kamei M., Sakaguchi H., Goda N., Fukamizu A., Nishida K., Takakura N. A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice. Development 2012, 139:1327-1335.
13. Lu Q., Jiang Y.R., Qian J., Tao Y. Apelin-13 regulates proliferation, migration and survival of retinal Müller cells under hypoxia. Diabetes Res. Clin. Pract. 2013, 99:158-167.
14. Shan P.F., Lu Y., Cui R.R., Jiang Y., Yuan L.Q., Liao E.Y. Apelin attenuates the osteoblastic differentiation of vascular smooth muscle cells. PLoS One 2011, 6:e17938.
15. Liu C., Su T., Li F., Li L., Qin X., Pan W., Feng F., Chen F., Liao D., Chen L. PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13. Acta Biochim. Biophys. Sin. 2010, 42:396-402.
16. Liu G.N., Teng Y.X., Yan W. Transfected synthetic DNA enzyme gene specifically inhibits Egr-1 gene expression and reduces neointimal hyperplasia following balloon injury in rats. Int. J. Cardiol. 2008, 129:118-124.
17. Wu Y., Han W., Liu G.N. A DNA enzyme targeting Egr-1 inhibits rat vascular smooth muscle cell proliferation by down-regulation of cyclin D1 and TGF-beta1. Braz. J. Med. Biol. Res. 2010, 43:17-24.
18. Yu H.W., Liu Q.F., Liu G.N. Positive regulation of the Egr-1/ osteopontin positive feedback loop in rat vascular smooth muscle cells by TGF-β, ERK, JNK, and p38 MAPK signaling. Biochem. Biophys. Res. Commun. 2010, 396:451-456.
19. Yu H.W., Liu Q.F., Liu G.N. Egr-1 upregulates OPN through direct binding to its promoter and OPN upregulates Egr-1 via the ERK pathway. Mol. Cell. Biochem. 2009, 332:77-84.