N-glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5641-5645

  Yamamoto, Yasuo ^a   Kawanishi, Eiji ^a   Koga, Yuichi ^a   Sakamaki, Shigeki ^a   Sakamoto, Toshiaki ^a   Ueta, Kiichiro ^a   Matsushita, Yasuaki ^a   Kuriyama, Chiaki ^a   Tsuda Tsukimoto, Minoru ^a   Nomura, Sumihiro ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Diabetes; Glucoside; N glucoside; SGLT2; Sodium dependent glucose cotransporter

Indexed keywords

GLUCOSE; GLUCOSIDE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; GLUCOSE URINE LEVEL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION; URINARY EXCRETION;

RATTUS;

DIABETES; GLUCOSIDE; N-GLUCOSIDE; SGLT2; SODIUM-DEPENDENT GLUCOSE COTRANSPORTER;

ANIMALS; GLUCOSE; GLUCOSIDES; HALF-LIFE; HUMANS; INDOLES; PROTEIN BINDING; RATS; SODIUM-GLUCOSE TRANSPORTER 2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884290137     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.042     Document Type: Article

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