CK2 inhibitor CX4945 induces sequential inactivation of proteins in the signaling pathways related with cell migration and suppresses metastasis of A549 human lung cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5609-5613

  Ku, Min Jeong ^a   Park, Jong Woo ^a   Ryu, Byung Jun ^b   Son, Young Jin ^c   Kim, Seong Hwan ^b   Lee, Sang Yeol ^a  

^a Gachon University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Sunchon National University   (South Korea)

Author keywords

CK2; CX 4945; Human lung cancer; Matrix metalloproteinases; Metastasis

Indexed keywords

ANTINEOPLASTIC AGENT; CASEIN KINASE II; CX 4945; DSA CX 4945; GELATINASE; GELATINASE A; MATRIX METALLOPROTEINASE 14; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL MIGRATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LUNG CANCER; METASTASIS; SIGNAL TRANSDUCTION; TUMOR INVASION;

CK2; CX-4945; HUMAN LUNG CANCER; MATRIX METALLOPROTEINASES; METASTASIS;

ANTINEOPLASTIC AGENTS; CASEIN KINASE II; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; GELATINASES; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NAPHTHYRIDINES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84884287257     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.043     Document Type: Article

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