Discovery of oral and inhaled PDE4 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5528-5532

  Ting, Pauline C ^a   Lee, Joe F ^a   Kuang, Rongze ^a   Cao, Jianhua ^a   Gu, Danlin ^a   Huang, Ying ^a   Liu, Zhidan ^a   Aslanian, Robert G ^a   Feng, Kung I ^a   Prelusky, Daniel ^a   Lamca, James ^a   House, Aileen ^a   Phillips, Jonathan E ^a   Wang, Peng ^a   Wu, Ping ^a   Lundell, Daniel ^a   Chapman, Richard W ^a   Celly, Chander S ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MERCK ANIMAL HEALTH   (United States)

Author keywords

Asthma; COPD; PDE4 inhibitor

Indexed keywords

PHOSPHODIESTERASE IV INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; IN VIVO STUDY; NONHUMAN; PNEUMONIA; RAT; VOMITING;

RATTUS;

ASTHMA; COPD; PDE4 INHIBITOR;

ADMINISTRATION, ORAL; ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DRUG EVALUATION, PRECLINICAL; HALF-LIFE; INHALATION; OXAZOLES; PHOSPHODIESTERASE 4 INHIBITORS; PROLINE; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884284098     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.056     Document Type: Article

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