Applications of the rare earth elements in cancer imaging and therapy

Current Nanoscience

Volumn 9, Issue 5, 2013, Pages 686-691

  Townley, Helen E ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cancer; Imaging; Nanoparticles; Rare earth elements

Indexed keywords

CANCER; CANCER IMAGING; HISTORY OF USE; IMAGING TECHNOLOGY; IN-VIVO IMAGING;

DISEASES; IMAGING TECHNIQUES; MAGNETIC RESONANCE IMAGING; MEDICAL IMAGING; NANOPARTICLES;

RARE EARTH ELEMENTS;

AZELAIC ACID; CERIUM; CERIUM OXIDE; CHELATE; CHLORIDE; CONTRAST MEDIUM; FLUORIDE; GADOLINIUM; LANTHANIDE; LANTHANUM; LANTHANUM CHLORIDE; LUTETIUM; METAL NANOPARTICLE; NANOCRYSTAL; PENTETIC ACID; PHOSPHATE; QUANTUM DOT; REACTIVE OXYGEN METABOLITE; SCANDIUM; TETRAXETAN; VANADIC ACID; YTTRIUM;

APOPTOSIS; ARTICLE; AUTOFLUORESCENCE; BLEACHING; CANCER CELL; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER THERAPY; CELL DEATH; CELL MEMBRANE FLUIDITY; CELL MEMBRANE PERMEABILITY; CHROMATOPHORE; DECOMPOSITION; DIAGNOSTIC IMAGING; DIAGNOSTIC IMAGING EQUIPMENT; ENERGY TRANSFER; ENVIRONMENTAL CHANGE; EXTRACELLULAR MATRIX; FLUORESCENCE IMAGING; GLIOBLASTOMA; HEMATOPOIETIC CELL; HUMAN; IN VIVO STUDY; LASER; LIGHT; LUMINESCENCE; METASTASIS; NANOTECHNOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTODYNAMIC THERAPY; PHOTOLUMINESCENCE; PRIORITY JOURNAL; RADIOFREQUENCY; SIGNAL NOISE RATIO;

EID: 84884267634     PISSN: 15734137     EISSN: 18756786     Source Type: Journal    
DOI: 10.2174/15734137113099990063     Document Type: Article

References (70)

1. Emsley, J. "Yttrium". Nature's Building Blocks: An A-Z Guide to the Elements. Oxford, England, UK: Oxford University Press. pp. 495-498, 2001.
2. Nockemann, P.; Beurer, E.; Driesen, K.; Van Deun, R.; Van Hecke, K.; Van Meervelt, L.; Binnemans, K. Photostability of a highly luminescent europium β-diketonate complex in imidazolium ionic liquids. Chem. Commun., 2005, 34, 4354-4356.
3. Naczynski, D.J.; Andelman, T.; Pal, D.; Chen, S.; Riman, R.E.; Roth, C.M.; Moghe, P.V. Albumin Nanoshell Encapsulation of Near-Infrared-Excitable Rare-Earth Nanoparticles Enhances Biocompatibility and Enables Targeted Cell Imaging. Small, 2010, 6(15), 1631-1640.
4. Bunzli, J-C. Benefiting from the unique properties of lanthanide ions. Acc. Chem. Res., 2006, 39(1), 53-61.
5. Sabbatini, N.; Guardigli, M.; Lehn, J.M. Luminescent lanthanide complexes as photochemical supramolecular devices. Coord. Chem. Rev., 1993, 123(1-2), 201-228.
6. Thibon, A.; Pierre, V.C. Principles of Responsive Lanthanide-Based Luminescent Probes. Anal. Bioanal. Chem., 2009, 394(1), 107-120.
7. Evans, W.J. Perspectives in Reductive Lanthanoid Chemistry. Coord. Chem. Rev., 2000, 206-207, 263-283.
8. 4 Nanocrystals. Adv. Funct. Mater., 2009, 19(6), 853-859.
9. 3:Eu nanocrystal phosphor through direct solution combustion. Nanotechnology, 2010, 21(34), 345601.
10. 3+-Codoped Nanocrystalline Yttria: Saturation and Thermal Effects. J. Phys. Chem. C, 2007, 111(36), 13611-13617.
11. Di, W.; Ren, X.; Zhao, H.; Shirahata, N.; Sakka, Y.; Qin, W. Single-phased luminescent mesoporous nanoparticles for simultaneous cell imaging and anticancer drug delivery. Biomaterials, 2011, 32(29), 7226-7233.
12. Casanova, D.; Bouzigues, C.; Nguyen, T-L.; Ramodiharilafy, R.O.; Bouzhir-Sima, L.; Gacoin, T.; Boilot, J-P.; Tharaux, P.L.; Alexandrou, A. Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells. Nat. Nanotechnol., 2009, 4, 581-585.
13. Ozben, T. Oxidative stress and apoptosis: impact on cancer therapy. J Pharm. Sci., 2007, 96(9), 2181-2196.
14. Toler, S.M.; Noe, D.; Sharma, A. Selective enhancement of cellular oxidative stress by chloroquine: implications for the treatment of glioblastoma multiforme. Neurosurg. Focus., 2006, 21(6), E10.
15. Frangioni, J.V. In vivo near-infrared fluorescence imaging. Curr. Opin. Chem. Biol., 2003, 7(5), 626-634.
16. Le Masne de Chermont, Q.; Chaneac, C.; Seguin, J.; Pelle, F.; Maitrejean, S.; Jolivet, J-P.; Gourier, D.; Bessodes, M.; Scherman, D. Nanoprobes with near-infrared persistent luminescence for in vivo imaging. Proc. Natl. Acad. Sci. USA., 2007, 104(22), 9266-9271.
17. Teng, Y.; Zhou, J.; Ma, Z.; Smedskjaer, M.; Qiu, J. Persistent near infrared phosphorescence from rare earth ions co-doped strontium aluminate phosphors. J. Electrochem. Soc., 2011, 158(2), K17-K19.
18. http://guedel.dcb.unibe.ch
19. Wang, F.; Liu, X. Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals. Chem. Soc. Rev., 2009, 38(4), 976-989.
20. Palmer, R.J.; Butenhoff, J.L.; Stevens, J.B. Cytotoxicity of the rare earth metals cerium, lanthanum, and neodymium in vitro: Comparisons with cadmium in a pulmonary macrophage primary culture system. Environ. Res., 1987, 43(1), 142-156.
21. 4: Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery. Adv. Mater., 2012, 24(9), 1226-1231.
22. 4 Upconversion Fluorescent Nanocrystals. Biomaterials, 2008, 29(30), 4122-4128.
23. Idris, N.M.; Li, Z.; Ye, L.; Sim, E.K.; Mahendran, R.; Ho, P.C.; Zhang, Y. Tracking transplanted cells in live animal using upconversion fluorescent nanoparticles. Biomaterials, 2009, 30(28), 5104-5413.
24. 4 Nanocrystals in Aqueous Solution Displaying Strong Up-Conversion Emission Chem. Chem. Mater., 2007, 19(6), 1396-1400.
25. 4 nanoparticles with upconversion fluorescence. Nanotechnology, 2006, 17(23), 5786-5791.
26. Chatterjee, D.K.; Rufaihah, A.J.; Zhang, Y. Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals. Biomaterials, 2008, 29(7), 29937-29943.
27. 4 Nanocrystals with Multicolour Upconversion Fluorescence Emission. Angew. Chem. Int. Ed., 2006, 45, 7732-7735.
28. Wang, Y-F; Sun, L-D; Xiao, J-W; Fang, W.; Zhou, J-C; Shen, J.; Yan, C-H. Rare-Earth Nanoparticles with Enhanced Upconversion Emission and Suppressed Rare-Earth-Ion Leakage. Chem. Eur. J., 2012, 18(18), 5558-5564.
29. 3:Er Nanostructures for bioimaging: Tuning of the upconversion fluorescence with silver nanoparticles. J. Am. Chem., 2010, 132(9), 2850-2851.
30. Babu, S.; Cho, J-H; Dowding, J. M; Heckert, E.; Komanski, C.; Das, S.; Colon, J.; Baker, C.H.; Bass, M.; Self, W.T.; Seal, S. Multicoloured redox active upconverter cerium oxide nanoparticle for bio-imaging and therapeutics. Chem. Commun., 2010, 46(37), 6915-6917.
31. 6. Optic. Mater., 2011, 33(4), 643-646.
32. 3+ Doped Fluoride Nanophosphors. Nano Lett., 2008, 8(11), 3834-3838.
33. Yu, X. F; Sun, Z.; Li, M.; Xiang, Y.; Wang, Q-Q; Tang, F.; Wu, Y.; Cao, Z.; Li, W. Neurotoxin-conjugated upconversion nanoprobes for direct visualization of tumors under near-infrared irradiation. Biomaterials, 2010, 31(33), 8724-8731.
34. Zhou, J.; Sun, Y.; Du, X.; Xiong, L.; Hu, H.; Li, F. Dual-modality in vivo imaging using rare-earth nanocrystals with near-infrared to near-infrared (NIR-to-NIR) upconversion luminescence and magnetic resonance properties. Biomaterials, 2010, 31(12), 3287-3295.
35. 3 targeted magnetic resonance imaging. Nat. Med. 1998, 4(5), 623-626.
36. Allen, M.; Bulte, J.W.M.; Liepold, L.; Basu, G.; Zywicke, H.A.; Frank, J.A.; Young, M.; Douglas T. Paramagnetic viral nanoparticles as potential high relaxivity magnetic resonance contrast agents. Magn. Reson. Med., 2005, 54(4), 807-812.
37. Park, J-A; Kim, H-K; Kim, J-H; Jeong, S-W; Jung, J-C; Lee, G-H; Lee, J.; Chang, Y.; Kim, T-J. Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent. Bioorg. Med. Chem. Lett., 2010, 20(7), 2287-2291.
38. Carr, D.H.; Brown, J.; Bydder, G.M., Steiner, RE, Weinmann, H.J.; Speck, U.; Hall, A.S.; Young, I.R. Gadolinium-DTPA as a contrast agent in MRI: initial clinical experience in 20 patients. Am. J. Roentgenol., 1984, 143(2), 215-224.
39. Bouzigues, C.; Alexandrou, T.G. Biomedical applications of rare-earth based nanoparticles. ACS Nano, 2011, 5(11), 8488-8505.
40. 2 nanoparticles for use as an efficient MRI contrast agent. Contrast Media Mol. Imaging., 2011, 6(2), 110-118.
41. Faucher, L.; Guay-Begin, A-A; Lagueux, J.; Cote, M-F; Petitclerc, E.; Fortin, M-A. Ultra-small gadolinium oxide nanoparticles to image brain cancer cells in vivo with MRI. Contrast Media Mol. Imaging, 2010, 6(4), 209-218.
42. Burai, L.; Toth, E.; Seibig, S.; Scopelliti, R.; Merbach, A.E. Solution and solid-state characterization of Eu (II) chelates: A possible route towards redox responsive MRI contrast agents. Chem-Eur. J., 2000, 6(20), 3761-3770.
43. Elst, L.V.; Roch, A.; Gillis, P.; Laurent, S.; Botteman, F.; Bulte, J.; Muller, R. Dy-DTPA Derivatives as Relaxation Agents for Very High Field MRI: The Beneficial Effect of Slow Water Exchange on the Transverse Relaxivities. Magn. Reson. Med., 2002, 47(6), 1121-1130.
44. Fenton, R.G.; Longo. D.L. Cancer cell Biology and Angiogenesis. Chapter 24 294-318 in Harrison's Haematology and Oncology, ed. DL Longo, Mc Graw Hill Medical 2010.
45. Dellian, M.; Yuan, F.; Trubetskoy, V.S.; Torchilin, V.P.; Jain, R.K. Vascular permeability in a human xenograft: molecular science dependence and cut off size. Cancer Res., 1995, 55(17), 3752-3756.
46. Maeda, H.; Bharate, G.Y.; Daruwall, J. Polymeric drugs for efficient tumourtargetted drug delivery based on EPR-effect. Eur. J. Pharm. Biopharm., 2009, 71(3), 409-419.
47. Ji, Y.J.; Xiao, B.; Wang, Z.H.; Cui, M.Z.; Lu, Y.Y. The suppression effect of light rare earth elements on proliferation of two cancer cell lines. Biomed. Environ., 2000, 13(4), 287-292.
48. Shi, P.; Huang, Z. Proteomic detection of changes in protein synthesis induced by lanthanum in BGC-823 human gastric cancer cells. Biomaterials, 2005, 18(1), 89-95
49. An, Y.; Li, R.; Wang, K. Effects of rare earth elements on proliferation of Human Hepatoma Cell SMMC-7721. J. Chinese Rare Earth Soc., 2005, 23, 105-108.
50. 3+) on growth of human normal liver line 7701 and human cervical carcinoma and the effect of cell apoptosis induced by lanthanide. J. Chinese Rare Earth Soc., 2006, 24, 484-488.
51. Man, N.; Yu, L; Yu, S-H.; Wen, L-P. Rare earth oxides as a new class of autophagy inducers. Autophagy, 2010, 6(2), 310-311.
52. Bai, X.; Yunjing, J.; Mingzhen, C. Effects of Lanthanum and Cerium on Malignant Proliferation and Expression of Tumor related Gene. Chin. J. Prev. Med., 1997, 31(4), 228-230.
53. 3+ ions. Biometals, 1998, 11, 107-112.
54. Dai, Y.; Li, J.; Li, J.; Yu, L.; Dai, G.; Hu, A.; Yuan L.; Wen, Z. Effects of rare earth compounds on growth and apoptosis of leukaemic cell lines. In vitro Cell Dev Bio-Anim., 2002, 38(7), 373-375.
55. Pałasz, A.; Czekaj, P. Toxicological and cytophysiological aspects of lanthanides action. Acta Biochim. Pol., 2000, 47(4), 1107-1114.
56. Su, X.; Zheng, X.; Ni, J. Lanthanum citrate induces anoikis of Hela cells. Cancer Lett., 2009, 285(2), 200-209.
57. Zhuang, G.S.; Zhou, Y.L.; Lu, H.J.; Lu, W.D.; Shou, M.F.; Wang, Y.; Tan, MG. Concentration of rare earth elements, As and Th in human brain and brain tumours, determined by neutron activation analysis. Biol. Trace Elem. Res., 1996, 53(1-3), 45-49.
58. Liu, X.; Wang, S.; Feng, C. Synthesis and anticancer properties of tungstosilic polyoxometalate containing 5-fluorouracil and neodymium. J. Rare Earths, 2010, 28(6), 965-968.
59. Gai, S.; Yang, P.; Li, C.; Wang, W.; Dai, Y.; Niu, N.; Lin, J. Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers. Adv. Funct. Mater., 2010, 20(7), 1166-1172.
60. Wang, C.; Cheng, L.; Liu, Z. Upconversion nanoparticles for potential cancer theranostics. Ther. Deliv., 2011a, 2(10), 1235-1239
61. Wang, C.; Tao, H.; Cheng, L.; Liu, Z. Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles. Biomaterials, 2011b, 32(26), 6145-6154.
62. Townley, H.E.; Rapa, E.; Wakefield, G.; Dobson, PJ. Nanoparticle augmented radiation treatment decreases cancer cell proliferation. Nanomedicine, 2012, 8(4), 526-536.
63. Trachootham, D.; Alexandre, J.; Huang, P. Targeting cancer cells by ROSmediated mechanisms: a radical therapeutic approach? Nat. Rev. Drug Discov., 2009, 8(7), 579-591.
64. Toyokuni S. Novel aspects of oxidative stress-associated carcinogenesis. Antioxid. Redox. Sign., 2006, 8(7-8), 1373-1377.
65. Ramanathan, B.; Jan, K.Y.; Chen, C.H.; Hour, T.C.; Yu, H.J., Pu, Y.S. Resistance to paclitaxel is proportional to cellular total antioxidant capacity. Cancer Res., 2005, 65(18), 8455-8460.
66. Hour, T.C.; Huang, C.Y.; Lin, C.C.; Chen, J.; Guan, J.Y.; Lee, J.M.; Pu, Y.S. Characterization of molecular events in a series of bladder urothelial carcinoma cell lines with progressive resistance to arsenic trioxide. Anti-cancer Drug., 2004, 15(8), 779-785.
67. Townley, H.E.; Kim, J.; Dobson, P.J. In vivo demonstration of enhanced radiotherapy using Rare Earth doped Titania Nanoparticles. Nanoscale, 2012, 4, 5043-5050.
68. Colon, J.; Hsieh, N.; Ferguson, A.; Kupelian, P.; Seal, S.; Jenkins, D.W., Baker, C.H. Cerium oxide nanoparticles protect gastrointestinal epithelium from radiation-induced damage by reduction of reactive oxygen species and upregulation of superoxide dismutase 2. Nanomedicine, 2010, 6(5), 697-705.
69. Niederhuber, J.E. "Global Cancer Control: An Essential Duty". NCI Cancer Bull., 2009.
70. Kolata, G. "As Other Death Rates Fall, Cancer's Scarcely Moves". The New York Times (April 24, 2009).