Resveratrol decreases B-cell lymphoma-2 expression and viability in GH3 pituitary adenoma cells of the rat

OncoTargets and Therapy

Volumn 6, Issue , 2013, Pages 1269-1276

  Voellger, Benjamin ^a   Kirches, Elmar ^a   Wilisch Neumann, Annette ^a   Weise, Andreas ^a   Tapia Perez, Jorge Humberto ^a   Rupa, Rosita ^a   Mawrin, Christian ^a   Firsching, Raimund ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

GH3 cells; Phytoestrogens; Resveratrol; Viability

Indexed keywords

BETA 2 MICROGLOBULIN; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; RESVERATROL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL ELECTROPHORESIS; GENE EXPRESSION; HYPOPHYSIS ADENOMA; IN VITRO STUDY; NONHUMAN; NUCLEOSOME; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 84884256973     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S45154     Document Type: Article

References (22)

1. Fahlbusch R, Buchfelder M. Pituitary surgery. In: Melmed S, editor. The Pituitary. 3rd ed. London: Academic Press; 2011:703-719.
2. Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL. Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms. Arch Biochem Biophys. 2009;486:95-102.
3. Zaldivar V, Magri ML, Zárate S, et al. Estradiol increases the Bax/Bcl-2 ratio and induces apoptosis in the anterior pituitary gland. Neuroendocrinology. 2009;90:292-300.
4. Jankowska A, Wasko R, Waligorska-Stachura J, et al. Survivin products in pituitary tumors. Neuroendocrinol Lett. 2008;29:1033-1037.
5. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
6. Wang C, Hu ZQ, Chu M, et al. Resveratrol inhibited GH3 cell growth and decreased prolactin level via estrogen receptors. Clin Neurol Neurosurg. 2012;114:241-248.
7. Mossmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55-63.
8. Berridge MV, Tan AS. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch Biochem Biophys. 1993;303:474-482.
9. Zini R, Morin C, Bertelli A, Bertelli AA, Tillement JP. Effects of resveratrol on the rat brain respiratory chain. Drugs Exp Clin Res. 1999;25:87-97.
10. Chan GK, Kleinheinz TL, Peterson D, Moffat JG. A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays. PLoS One. 2013;8:e63583.
11. Miki I, Ishihara N, Otoshi M, Kase H. Simple colorimetric cell-cell adhesion assay using MTT-stained leukemia cells. J Immunol Methods. 1993;164:255-261.
12. Tanase C, Ogrezeanu I, Badiu C. Molecular Pathology of Pituitary Adenomas. London: Elsevier; 2012:45-52.
13. Jones MK, Padilla OR, Webb NA, Norng M. The anti-apoptosis protein, survivin, mediates gastric epithelial cell cytoprotection against ethanol-induced injury via activation of the p34(cdc2) cyclin-dependent kinase. J Cell Physiol. 2008;215:750-764.
14. Jones MK, Padilla OR, Zhu E. Survivin is a key factor in the differential susceptibility of gastric endothelial and epithelial cells to alcohol-induced injury. J Physiol Pharmacol. 2010;61:253-264.
15. Walle T. Bioavailability of resveratrol. Ann N Y Acad Sci. 2011;1215: 9-15.
16. Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004;32:1377-1382.
17. Lin X, Wu G, Huo WQ, Zhang Y, Jin FS. Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells. Int J Urol. 2012;19:757-764.
18. Zhou JH, Cheng HY, Yu ZQ, He DW, Pan Z, Yang DT. Resveratrol induces apoptosis in pancreatic cancer cells. Chin Med J (Engl). 2011;124:1695-1699.
19. Fang Y, DeMarco VG, Nicholl MB. Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis. Cancer Sci. 2012;103:1090-1098.
20. Tak JK, Lee JH, Park JW. Resveratrol and piperine enhance radiosensitivity of tumor cells. BMB Rep. 2012;45:242-246.
21. Huang H, Lin H, Zhang X, Li J. Resveratrol reverses temozolomide resistance by downregulation of MGMT in T98G glioblastoma cells by the NF-κB-dependent pathway. Oncol Rep. 2012;27:2050-2056.
22. Gupta SC, Kannappan R, Reuter S, Kim JH, Aggarwal BB. Chemosensitization of tumors by resveratrol. Ann N Y Acad Sci. 2011;1215:150-160.