An attenuated cytomegalovirus vaccine with a deletion of a viral chemokine gene is protective against congenital CMV transmission in a guinea pig model

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Leviton, Michael P ^a   Lacayo, Juan C ^a,b   Choi, K Yeon ^a,c   Hernandez Alvarado, Nelmary ^a   Wey, Andrew ^d   Schleiss, Mark R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOMEGALOVIRUS VACCINE; PHOSPHORIBOSYLTRANSFERASE; PLACEBO; VIRUS DNA; LIVE VACCINE; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BIRTH WEIGHT; CELL CULTURE; CHEMOPROPHYLAXIS; CONGENITAL INFECTION; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; FOOT PAD; GENE DELETION; GUINEA PIG MODEL; HISTOPATHOLOGY; IMMUNOGENICITY; INFLAMMATION; INOCULATION; KNOCKOUT GENE; MALE; MARE; MORTALITY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SALIVARY GLAND; THIRD TRIMESTER PREGNANCY; VACCINATION; VIREMIA; VIRUS ATTENUATION; VIRUS GENE; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS TRANSMISSION; WILD TYPE; ANIMAL; CELL LINE; CYTOMEGALOVIRUS; DISEASE TRANSMISSION; GENE ORDER; GENETICS; GUINEA PIG; IMMUNOLOGY; PREGNANCY; PREGNANCY OUTCOME; VERTICAL TRANSMISSION; CYTOMEGALOVIRUS INFECTIONS; TRANSMISSION;

ANIMALS; CELL LINE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; CYTOMEGALOVIRUS VACCINES; FEMALE; GENE ORDER; GUINEA PIGS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; PREGNANCY; PREGNANCY OUTCOME; SEQUENCE DELETION; VACCINATION; VACCINES, ATTENUATED; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84884249571     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/906948     Document Type: Article

References (43)

1. Nyholm J. L., Schleiss M. R., Prevention of maternal cytomegalovirus infection: current status and future prospects. International Journal of Women's Health 2010 2 1 23 35 2-s2.0-77953401818
2. Oliver S. E., Cloud G. A., Sánchez P. J., Demmler G. J., Dankner W., Shelton M., Jacobs R. F., Vaudry W., Pass R. F., Soong S.-J., Whitley R. J., Kimberlin D. W., Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system. Journal of Clinical Virology 2009 46 supplement 4 S22 S26 2-s2.0-71649099631 10.1016/j.jcv.2009.08.012
3. Whitley R. J., Congenital cytomegalovirus infection: epidemiology and treatment. Advances in Experimental Medicine and Biology 2004 549 155 160 2-s2.0-3242780934
4. Swanson E. C., Schleiss M. R., Congenital cytomegalovirus infection: new prospects for prevention and therapy. Pediatric Clinics of North America 2013 60 2 335 349
5. Schleiss M. R., Nonprimate models of congenital cytomegalovirus (CMV) infection: gaining insight into pathogenesis and prevention of disease in newborns. ILAR Journal 2006 47 1 65 72 2-s2.0-29544437911
6. Kern E. R., Pivotal role of animal models in the development of new therapies for cytomegalovirus infections. Antiviral Research 2006 71 2-3 164 171 2-s2.0-33747343175 10.1016/j.antiviral.2006.05.018
7. Miller-Kittrell M., Sparer T. E., Feeling manipulated: cytomegalovirus immune manipulation. Virology Journal 2009 6, article 4 2-s2.0-60549097787 10.1186/1743-422X-6-4
8. Hengel H., Brune W., Koszinowski U. H., Immune evasion by cytomegalovirus-survival strategies of a highly adapted opportunist. Trends in Microbiology 1998 6 5 190 197 2-s2.0-0032077622 10.1016/S0966-842X(98)01255-4
9. Mocarski E. S. Jr., Immunomodulation by cytomegaloviruses: manipulative strategies beyond evasion. Trends in Microbiology 2002 10 7 332 339 2-s2.0-0036646149 10.1016/S0966-842X(02)02393-4
10. Mocarski E. S. Jr., Immune escape and exploitation strategies of cytomegaloviruses: impact on and imitation of the major histocompatibility system. Cellular Microbiology 2004 6 8 707 717 2-s2.0-4043117595 10.1111/j.1462-5822.2004.00425.x
11. Vischer H. F., Vink C., Smit M. J., A viral conspiracy: hijacking the chemokine system through virally encoded pirated chemokine receptors. Current Topics in Microbiology and Immunology 2006 303 121 154 2-s2.0-33645419087
12. Powers C., DeFilippis V., Malouli D., Früh K., Cytomegalovirus immune evasion. Current Topics in Microbiology and Immunology 2008 325 333 359 2-s2.0-48849096987 10.1007/978-3-540-77349-8-19
13. Haggerty S. M., Schleiss M. R., A novel CC-chemokine homolog encoded by guinea pig cytomegalovirus. Virus Genes 2002 25 3 271 279 2-s2.0-0036455094 10.1023/A:1020923924471
14. Penfold M., Miao Z., Wang Y., Haggerty S., Schleiss M. R., A macrophage inflammatory protein homolog encoded by guinea pig cytomegalovirus signals via CC chemokine receptor 1. Virology 2003 316 2 202 212 2-s2.0-0344120227 10.1016/S0042-6822(03)00581-6
15. Schraff S. A., Brown D. K., Schleiss M. R., Meinzen-Derr J., Greinwald J. H., Choo D. I., The role of CMV inflammatory genes in hearing loss. Otology and Neurotology 2007 28 7 964 969 2-s2.0-34848869999 10.1097/MAO.0b013e318067bd42
16. Schraff S. A., Schleiss M. R., Brown D. K., Meinzen-Derr J., Choi K. Y., Greinwald J. H., Choo D. I., Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury. Otolaryngology 2007 137 4 612 618 2-s2.0-34548832504 10.1016/j.otohns.2007.03.044
17. Bernstein D. I., Vaccines for cytomegalovirus. Infectious Disorders Drug Targets 2011 11 5 514 525 10.2174/187152611797636695
18. Söderberg-Nauclér C., Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? Journal of Internal Medicine 2006 259 3 219 246 2-s2.0-33645099725 10.1111/j.1365-2796. 2006.01618.x
19. Čičin-Šain L., Bubić I., Schnee M., Ruzsics Z., Mohr C., Jonjić S., Koszinowski U. H., Targeted deletion of regions rich in immune-evasive genes from the cytomegalovirus genome as a novel vaccine strategy. Journal of Virology 2007 81 24 13825 13834 2-s2.0-37049031043 10.1128/JVI.01911-07
20. Mohr C. A., Cîcîn-Saîn L., Wagner M., Sacher T., Schnee M., Ruzsics Z., Koszinowski U. H., Engineering of cytomegalovirus genomes for recombinant live herpesvirus vaccines. International Journal of Medical Microbiology 2008 298 1-2 115 125 2-s2.0-36749076662 10.1016/j.ijmm.2007.07.008
21. Mohr C. A., Arapovic J., Mühlbach H., Panzer M., Weyn A., Dölken L., Krmpotic A., Voehringer D., Ruzsics Z., Koszinowski U., Sacher T., A spread-deficient cytomegalovirus for assessment of first-target cells in vaccination. Journal of Virology 2010 84 15 7730 7742 2-s2.0-77954516840 10.1128/JVI.02696-09
22. Johnson K. P., Mouse cytomegalovirus: placental infection. Journal of Infectious Diseases 1969 120 4 445 450 2-s2.0-0014588992
23. McGregor A., Schleiss M. R., Molecular cloning of the guinea pig cytomegalovirus (GPCMV) genome as an infectious bacterial artificial chromosome (BAC) in Escherichia coli. Molecular Genetics and Metabolism 2001 72 1 15 26 2-s2.0-0035715264 10.1006/mgme.2000.3102
24. McGregor A., Liu F., Schleiss M. R., Identification of essential and non-essential genes of the guinea pig cytomegalovirus (GPCMV) genome via transposome mutagenesis of an infectious BAC clone. Virus Research 2004 101 2 101 108 2-s2.0-1642367352 10.1016/j.virusres.2003.12.030
25. Saederup N., Aguirre S. A., Sparer T. E., Bouley D. M., Mocarski E. S., Murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is a determinant of dissemination that increases inflammation at initial sites of infection. Journal of Virology 2001 75 20 9966 9976 2-s2.0-0034806363 10.1128/JVI.75.20. 9966-9976.2001
26. Crumpler M. M., Choi K. Y., McVoy M. A., Schleiss M. R., A live guinea pig cytomegalovirus vaccine deleted of three putative immune evasion genes is highly attenuated but remains immunogenic in a vaccine/challenge model of congenital cytomegalovirus infection. Vaccine 2009 27 31 4209 4218 2-s2.0-67349171033 10.1016/j.vaccine.2009.04.036
27. Schleiss M. R., Cloning and characterization of the guinea pig cytomegalovirus glycoprotein B gene. Virology 1994 202 1 173 185 2-s2.0-0027998619 10.1006/viro.1994.1333
28. Schleiss M. R., Bourne N., Bravo F. J., Jensen N. J., Bernstein D. I., Quantitative-competitive PCR monitoring of viral load following experimental guinea pig cytomegalovirus infection. Journal of Virological Methods 2003 108 1 103 110 2-s2.0-0037357489 10.1016/S0166-0934(02)00265-3
29. Muffly T. M., Barber M. D., Insertion and removal of vaginal mesh for pelvic organ prolapse. Clinical Obstetrics and Gynecology 2010 53 1 99 114 2-s2.0-77049097916 10.1097/GRF.0b013e3181cefab8
30. Nozawa N., Yamamoto Y., Fukui Y., Katano H., Tsutsui Y., Sato Y., Yamada S., Inami Y., Nakamura K., Yokoi M., Kurane I., Inoue N., Identification of a 1.6 kb genome locus of guinea pig cytomegalovirus required for efficient viral growth in animals but not in cell culture. Virology 2008 379 1 45 54 2-s2.0-48949100380 10.1016/j.virol.2008.06.018
31. Kaptein S. J. F., van Cleef K. W. R., Gruijthuijsen Y. K., Beuken E. V. H., Van Buggenhout L., Beisser P. S., Stassen F. R. M., Bruggeman C. A., Vink C., The r131 gene of rat cytomegalovirus encodes a proinflammatory CC chemokine homolog which is essential for the production of infectious virus in the salivary glands. Virus Genes 2004 29 1 43 61 2-s2.0-3142510686 10.1023/B:VIRU.0000032788.53592.7c
32. Schleiss M. R., Bourne N., Stroup G., Bravo F. J., Jensen N. J., Bernstein D. I., Protection against congenital cytomegalovirus infection and disease in guinea pigs, conferred by a purified recombinant glycoprotein B vaccine. Journal of Infectious Diseases 2004 189 8 1374 1381 2-s2.0-2142705176 10.1086/382751
33. Fleming P., Davis-Poynter N., Degli-Esposti M., Densley E., Papadimitriou J., Shellam G., Farrell H., The murine cytomegalovirus chemokine homolog, m131/129, is a determinant of viral pathogenicity. Journal of Virology 1999 73 8 6800 6809 2-s2.0-0032786534
34. Slavuljica I., Busche A., Babić M., Mitrović M., Gašparović I., Cekinović D., Car E. M., Pugel E. P., Ciković A., Lisnić V. J., Britt W. J., Koszinowski U., Messerle M., Krmpotić A., Jonjić S., Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties. Journal of Clinical Investigation 2010 120 12 4532 4545 2-s2.0-78649899880 10.1172/JCI43961
35. Sung H., Schleiss M. R., Update on the current status of cytomegalovirus vaccines. Expert Review of Vaccines 2010 9 11 1303 1314 2-s2.0-78649344229 10.1586/erv.10.125
36. Yamada S., Nozawa N., Katano H., Fukui Y., Tsuda M., Tsutsui Y., Kurane I., Inoue N., Characterization of the guinea pig cytomegalovirus genome locus that encodes homologs of human cytomegalovirus major immediate-early genes, UL128, and UL130. Virology 2009 391 1 99 106 2-s2.0-67650732354 10.1016/j.virol.2009.05.034
37. Ryckman B. J., Chase M. C., Johnson D. C., HCMV gH/gL/UL128-131 interferes with virus entry into epithelial cells: evidence for cell type-specific receptors. Proceedings of the National Academy of Sciences of the United States of America 2008 105 37 14118 14123 2-s2.0-52949141855 10.1073/pnas.0804365105
38. Ryckman B. J., Jarvis M. A., Drummond D. D., Nelson J. A., Johnson D. C., Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion. Journal of Virology 2006 80 2 710 722 2-s2.0-30344435010 10.1128/JVI.80.2.710-722.2006
39. Ryckman B. J., Rainish B. L., Chase M. C., Borton J. A., Nelson J. A., Jarvis M. A., Johnson D. C., Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells. Journal of Virology 2008 82 1 60 70 2-s2.0-37349028312 10.1128/JVI.01910-07
40. Hahn G., Revello M. G., Patrone M., Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes. Journal of Virology 2004 78 18 10023 10033
41. Auerbach M., Yan D., Fouts A., Characterization of the guinea pig CMV gH/gL/GP129/GP131/GP133 complex in infection and spread. Virology 2013 441 1 75 84 10.1016/j.virol.2013.03.008
42. Cui X., McGregor A., Schleiss M. R., McVoy M. A., Cloning the complete guinea pig cytomegalovirus genome as an infectious bacterial artificial chromosome with excisable origin of replication. Journal of Virological Methods 2008 149 2 231 239 2-s2.0-41349100866 10.1016/j.jviromet.2008.01.031
43. + T cell epitope recognition paradigms. Science 2013 340 6135 1 17 10.1126/science.1237874