Electrophysiological characteristics of cardiomyocyte-like cells from rat bone marrow derived mesenchymal stem cells by four inductors

Chinese Medical Journal

Volumn 126, Issue 18, 2013, Pages 3528-3533

  Liu, Bo Wu ^a   Lü, An Lin ^a   Hou, Jing ^a   Huang, Wei ^a   Hou, Hong ^a   Hou, Zhao Lei ^a   Da, Jing ^a   Ai, Shi Yi ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bone marrow mesenchymal stem cells; Cardiomyocyte; Differentiation; Electrophysiological characteristics

Indexed keywords

ANGIOTENSIN II; AZACITIDINE; BONE MORPHOGENETIC PROTEIN 2; CONNEXIN 43; GREEN FLUORESCENT PROTEIN; P53 INHIBITOR ALPHA; PROTEIN; TROPONIN T; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONFOCAL LASER MICROSCOPY; ELECTROPHYSIOLOGY; FLOW CYTOMETRY; HEART MUSCLE CELL; IMMUNOFLUORESCENCE MICROSCOPY; MESENCHYMAL STEM CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; ELECTROPHYSIOLOGY; MALE; MESENCHYMAL STROMAL CELLS; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84884231334     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20122675     Document Type: Article

References (19)

1. Lauer MS. Advancing cardiovascular research. Chest 2012; 141: 500-505.
2. Nabel GN. Cardiovascular disease. N Engl J Med 2003; 349: 60-72.
3. Bosch X, Marrugat J, Sanchis J. Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes. Cochrane Database Syst Rev 2010; CD002130.
4. Taglieri N, Di Mario C. Percutaneous coronary intervention following thrombolysis: for whom and when? Acute Card Care 2009; 11: 195-203.
5. Yoshioka D, Sakaguchi T, Saito S, Miyagawa S, Nishi H, Yoshikawa Y, et al. Predictor of early mortality for severe heart failure patients with left ventricular assist device implantation. Circ J 2012; 76: 1631-1638.
6. Wang H, Zhou J, Liu Z, Wang C. Injectable cardiac tissue engineering for the treatment of myocardial infarction. J Cell Mol Med 2010; 14: 1044-1055.
7. Price MJ, Chou CC, Frantzen M, Miyamoto T, Kar S, Lee S, et al. Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties. Int J Cardiol 2006; 111: 231-239.
8. Schueller PO, Meyer C, Brehm M, Wernet P, Schannwell CM, Strauer BE. Intracoronary autologous bone marrow cell transplantation beneficially modulates heart rate variability. Int J Cardiol 2007; 119: 398-399.
9. Xing YJ, Lü AL, Zhao XM, Li F, Wang L, Du JJ. Current state of myocardial tissue engineering. Chin Med J 2009; 122: 1811-1815.
10. Yan X, Lv A, Xing Y, Liu B, Hou J, Huang W, et al. Inhibition of p53-p21 pathway promotes the differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Mol Cell Biochem 2011; 353: 21-28.
11. Xing Y, Lv A, Wang L, Yan X. The combination of angiotensin II and 5AZAcytidine promotes cardiomyocyte differentiation of rat bone marrow mesenchymal stem cells. Mol Cell Biochem 2012; 360: 279-287.
12. Balana B, Nicoletti C, Zahanich I, Graf EM, Christ T, Boxberger S. 5AZAcytidine induces changes in electrophysiological properties of human mesenchymal stem cells. Cell Res 2006; 16: 949-960.
13. Wang Y, Zhang G, Hou Y, Chen J, Wang J, Zou C, et al. Transplantation of microencapsulated Schwann cells and mesenchymal stem cells augment angiogenesis and improve heart function. Mol Cell Biochem 2012; 366: 139-147.
14. Rose RA, Jiang H, Wang X, Helke S, Tsoporis JN, Gong N, et al. Bone marror derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells 2008; 26: 2884-2892.
15. Miyoshi S, Ikegami Y, Itabashi Y, Furuta A, Umezawa A, Ogawa S. Cardiac cell therapy and arrhythmias. Circ J 2007; 71 Suppl A: A45-A49.
16. Liu BW, Lü AL, Hou J, Huang W, Li Y, Hou ZL, et al. Cardiac differentiation and electrophysiology characteristics of bone marrow mesenchymal stem cells. Chin Med J 2012; 125: 3318-3324.
17. Arufe MC, De la Fuente A, Fuentes I, de Toro FJ, Blanco FJ. Chondrogenic potential of subpopulations of cells expressing mesenchymal stem cell markers derived from human synovial membranes. J Cell Biochem 2010; 111: 834-845.
18. Wolfe M, Pochampally R, Swaney W, Reger RL. Isolation and culture of bone marror derived human multipotent stromal cells (hMSCs). Methods Mol Biol 2008; 449: 3-25.
19. Chang Q, Yan L, Wang CZ, Zhang WH, Hu YZ, Wu BY. In vivo transplantation of bone marrow mesenchymal stem cells accelerates repair of injured gastric mucosa in rats. Chin Med J 2012; 125: 1169-1174.