Morphology of atherosclerotic lesions

Inflammation and Atherosclerosis

Volumn 9783709103388, Issue , 2012, Pages 19-37

  Simionescu, Maya ^a   Sima, Anca V ^a  

^a INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84884220025     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-7091-0338-8_2     Document Type: Chapter

References (54)

1. Millonig G, Malcom GT, Wick G (2002) Early inflammatory-immunological lesions in juvenile atherosclerosis from the pathobiological determinants of atherosclerosis in youth (PDAY)-study. Atherosclerosis 160:441-448
2. Libby P, Ridker PM, Göran K (2009) Hansson, inflammation in atherosclerosis, from patho-physiology to practice. J Am Coll Cardiol 54:2129-2138
3. Nielsen LB, Nordestgaard BG, Stender S, Kjeldsen K (1992) Aortic permeability to LDL as a predictor of aortic cholesterol accumulation in cholesterol-fed rabbits. Arterioscler Thromb 12:1402-1409
4. Nordestgaard BG, Hjelms E, Stender S, Kjeldsen K (1990) Different efflux pathways for high and low density lipoproteins from porcine aortic intima. Arterioscler Thromb Vasc Biol 10:477-485
5. Schwenke DC, StClair RW (1993) Influx, efflux, and accumulation of LDL in normal arterial areas and atherosclerotic lesions of white Carneau pigeons with naturally occurring and cholesterol aggravated aortic atherosclerosis. Arterioscler Thromb 13:1368-1381
6. Vasile E, Antohe F, Simionescu M, Simionescu N (1989) Transport pathways of beta-VLDL by aortic endothelium of normal and hypercholesterolemic rabbits. Atherosclerosis 75:195-210
7. Nordestgaard BG, Hjelms E, Stender S, Kjeldsen K (1990) Different efflux pathways for high and low density lipoproteins from porcine aortic intima. Arteriosclerosis 10:477-485
8. Faggiotto A, Ross R, Harker L (1984) Studies of hypercholesterolemia in the nonhuman primate I. Changes that lead to fatty streak formation. Arterioscler Thromb Vasc Biol 4:323-340
9. Kruth HS (1983) Filipin-positive, oil red 0-negative particles in atherosclerotic lesions induced by cholesterol feeding. Lab Invest 50:87-93
10. Nistor A, Bulla A, Filip DA, Radu A (1987) The hyperlipidemic hamster as a model of experimental atherosclerosis. Atherosclerosis 68:159-173
11. Simionescu N, Vasile E, Lupu F, Popescu G, Simionescu M (1986) Prelesional events in atherogenesis: accumulation of extracellular cholesterol rich liposomes in the arterial intima and cardiac valves of hyperlipidemic rabbits. Am J Pathol 123:85-101
12. Kruth HS (1984) Localization of unesterified cholesterol in human atherosclerotic lesions. Demonstration of filipin positive, Oil-Red-0-negative particles. Am J Pathol 114:201-208
13. Tirziu D, Dobrian A, Tasca C, Simionescu M, Simionescu N (1995) Intimal thickenings of human aortas contain modified reassembled lipoproteins. Atherosclerosis 112:101-114
14. Sima A, Stancu C, Simionescu M (2009) Vascular endothelium in atherosclerosis. Cell Tissue Res 335:191-203
15. Tabas I, Williams KJ, Borén J (2007) Macrophages, apoptotic cells and cholesterol-strategies for survival. Circulation 116:1832-1844
16. Steinberg D (2009) The LDL modification hypothesis of atherogenesis: an update. J Lipid Res 50:S376-S381
17. Ishigakia Y, Okaa Y, Katagiri H (2009) Circulating oxidized LDL: a biomarker and a pathogenic factor. Curr Opin Lipidol 20:363-369
18. Tsimikas S, Willerson JT, Ridker PM (2006) C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 47:C19-C31
19. Filip DA, Nistor A, Bulla A, Radu A, Simionescu M (1987) Cellular events in the development of the valvular atherosclerotic lesions induced by experimental atherosclerosis. Atherosclerosis 67:199-214
20. Sima A, Bulla A, Simionescu N (1990) Experimental obstructive coronary atherosclerosis in the hyperlipidemic hamster. J Submicrosc Cytol Pathol 22:1-6
21. Simionescu M (2007) Implications of early structural-functional changes in the endothelium for vascular disease. Arterioscler Thromb Vasc Biol 27:266-274
22. Mompeo B, Popov D, Sima A, Constantinescu E, Simionescu M (1998) Diabetes induced structural changes of venous and arterial endothelium and smooth muscle cells. J Submicrosc Cytol Pathol 30:475-484
23. Sima A, Stancu C, Constantinescu E (2004) The hyperlipidemic hamster, a model to study atheroma formation and anti-atherosclerotic drugs effects. In: Simionescu M, Sima A, Popov D (eds) Cellular dysfunction in atherosclerosis and diabetes-reports from bench to bedside. Academy Publishing House, Bucharest, pp 309-322
24. Boisvert WA, Santiago R, Curtiss LK, Terkeltaub RA (1998) A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest 101:353-363
25. Haley KJ, Lilly CM, Yang JH, Feng Y, Kennedy SP, Turi TG, Thompson JF, Sukhova GH, Libby P, Lee RT (2000) Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation. Circulation 102:2185-2189
26. Geissmann F, Jung S, Littman DR (2003) Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19(1):71-82
27. Weber C, Zernecke A, Libby P (2008) The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol 8:802-815
28. Woollard KJ, Geissmann F (2010) Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol 7:77-86
29. Davi G, Patrono C (2007) Platelet activation and atherothrombosis. New Engl J Med 357: 2482-2494
30. Huo Y, Schober A, Forlow SB, Smith DF, Hyman MC, Jung S, Littman DR, Weber C, Ley K (2003) Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipo-protein E. Nat Med 9:61-67
31. Hansson GK (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352:1685-1695
32. Packard RR, Lichtman AH, Libby P (2009) Innate and adaptive immunity in atherosclerosis. Semin Immunopathol 31(1):5-22
33. Bobryshev YV (2005) Dendritic cells in atherosclerosis: current status of the problem and clinical relevance. Eur Heart J 26:1700-1704
34. Weis M, Schlichting CL, Engleman EG, Cooke JP (2002) Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases. Arterioscler Thromb Vasc Biol 22:1817-1823
35. Galkina E, Ley K (2009) Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol 27:165-197
36. Packard RR, Maganto-Garcia E, Gotsman I, Tabas I, Libby P, Lichtman AH (2008) CD11c (+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Circ Res 103:965-973
37. Soehnlein O, Zernecke A, Eriksson EE, Rothfuchs AG, Pham CT, Herwald H, Bidzhekov K, Rottenberg ME, Weber C, Lindbom L (2008) Neutrophil secretion products pave the way for inflammatory monocytes. Blood 112:1461-1471
38. Soehnlein O, Weber C, Lindbom L (2009) Neutrophil granule proteins tune monocytic cell function. Trends Immunol 30:538-546
39. Soehnlein O, Lindbom L, Weber C (2009) Mechanisms underlying neutrophil-mediated monocyte recruitment. Blood 114:4613-4623
40. Zernecke A, Bot I, Djalali-Talab Y et al (2008) Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res 102:209-217
41. Luxa CA, Koschinskib A, Derscha K, Husmanna M, Bhakdia S (2009) Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein. Atherosclerosis 207:116-122
42. Drechsler M, Megens RTA, van Zandvoort M, Weber C, Soehnlein O (2010) Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation 122:1837-1845
43. Baetta R, Corsini A (2010) Role of polymorphonuclear neutrophils in atherosclerosis: current state and future perspectives. Atherosclerosis 210:1-13
44. Lappalainen J, Lindstedt KA, Oksjoki R, Kovanen PT (2011) OxLDL-IgG immune complexes induce expression and secretion of proatherogenic cytokines by cultured human mast cells. Atherosclerosis 214(2):357-363
45. Kovanen PT (2009) Mast cells in atherogenesis: actions and reactions. Curr Atheroscler Rep 11:214-219
46. Tiwari RL, Singh V, Barthwal MK (2008) Macrophages: an elusive yet emerging therapeutic target of atherosclerosis. Med Res Rev 28:483-544
47. Velican C, Velican D (1985) Study of coronary intimal thickening. Atherosclerosis 56: 331-344
48. Stary HC (2000) Natural history and histological classification of atherosclerotic lesions: an update. Arterioscler Thromb Vasc Biol 20:1177-1178
49. Tabas I, Tall A, Accili D (2010) The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circ Res 106:58-67
50. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 20:1262-1275
51. Rudd JFH, Narula J, Strauss HW, Virmani R, Machac J, Klimas M et al (2010) Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography. Ready for prime time? J Am Coll Cardiol 55:2527-2535
52. Kolodgie FD, Nakazawa G, Sangiorgi G, Ladich E, Burke AP, Virmani R (2007) Pathology of atherosclerosis and stenting. Neuroimaging Clin N Am 17(3):285-310
53. Watanabe M, Sangawa A, Sasaki Y, Yamashita M, Tanaka-Shintani M, Shintaku M, Ishikawa Y (2007) Distribution of inflammatory cells in adventitia changed with advancing atherosclerosis of human coronary artery. J Atheroscler Thromb 14:325-331
54. Langheinrich AC, Kampschulte M, Buch T, Bohle RM (2007) Vasa vasorum and atherosclerosis. Quid novi? Thromb Haemost 97:873-879