Effect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status

Intensive Care Medicine

Volumn 39, Issue 4, 2013, Pages 727-733

  White, Hayden ^a   Venkatesh, Balasubramanian ^b   Jones, Mark ^b   Worrall, Simon ^b   Chuah, Teong ^b   Ordonez, Jenny ^b  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Beta hydroxybutyrate; Brain injury; Hypertonic saline; Intracranial hypertension; Ketone bodies; Ketones

Indexed keywords

3 HYDROXYBUTYRIC ACID; HYPERTONIC SOLUTION; KETONE; SODIUM CHLORIDE;

ACID BASE BALANCE; ALKALOSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN; BRAIN LEVEL; BRAIN METABOLISM; CEREBROSPINAL FLUID; COMPARATIVE STUDY; CONTROLLED STUDY; NONHUMAN; RAT; TREATMENT DURATION;

3-HYDROXYBUTYRIC ACID; ANIMALS; BLOOD CHEMICAL ANALYSIS; BRAIN CHEMISTRY; CEREBROSPINAL FLUID; INFUSIONS, INTRAVENOUS; KETONE BODIES; RATS; RATS, SPRAGUE-DAWLEY; SALINE SOLUTION, HYPERTONIC;

EID: 84884212338     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-012-2790-y     Document Type: Article

References (33)

1. Owen OE, Morgan AP, Kemp HG, Sullivan JM, Herrera MG, Cahill GF Jr (1967) Brain metabolism during fasting. J Clin Invest 46:1589-1595
2. Prins ML (2008) Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab 28:1-16
3. Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, Paulson OB (1996) Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Physiol 270:E746-E751
4. Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF Jr (2001) Ketone bodies, potential therapeutic uses. IUBMB Life 51:241-247
5. Kashiwaya Y, Sato K, Tsuchiya N, Thomas S, Fell DA, Veech RL, Passonneau JV (1994) Control of glucose utilization in working perfused rat heart. J Biol Chem 269:25502-25514
6. Suzuki M, Suzuki M, Kitamura Y, Mori S, Sato K, Dohi S, Sato T, Matsuura A, Hiraide A (2002) Beta-hydroxybutyrate, a cerebral function improving agent, protects rat brain against ischemic damage caused by permanent and transient focal cerebral ischemia. Jpn J Pharmacol 89:36-43
7. Puchowicz MA, Zechel JL, Valerio J, Emancipator DS, Xu K, Pundik S, LaManna JC, Lust WD (2008) Neuroprotection in diet-induced ketotic rat brain after focal ischemia. J Cereb Blood Flow Metab 28:1907-1916
8. Gasior M, Rogawski MA, Hartman AL (2006) Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol 17:431-439
9. Reger MA, Henderson ST, Hale C, Cholerton B, Baker LD, Watson GS, Hyde K, Chapman D, Craft S (2004) Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging 25:311-314
10. Hasselbalch SG, Knudsen GM, Jakobsen J, Hageman LP, Holm S, Paulson OB (1994) Brain metabolism during short-term starvation in humans. J Cereb Blood Flow Metab 14:125-131
11. Leino RL, Gerhart DZ, Duelli R, Enerson BE, Drewes LR (2001) Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem Int 38:519-527
12. Pan JW, Rothman TL, Behar KL, Stein DT, Hetherington HP (2000) Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis. J Cereb Blood Flow Metab 20:1502-1507
13. Pan JW, Telang FW, Lee JH, de Graaf RA, Rothman DL, Stein DT, Hetherington HP (2001) Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain. J Neurochem 79:539-544
14. Linde R, Hasselbalch SG, Topp S, Paulson OB, Madsen PL (2006) Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat. J Cereb Blood Flow Metab 26:170-180
15. Prins ML, Lee SM, Fujima LS, Hovda DA (2004) Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats. J Neurochem 90:666-672
16. Eilig I, Rachinsky M, Artru AA, Alonchin A, Kapuler V, Tarnapolski A, Shapira Y (2001) The effect of treatment with albumin, hetastarch, or hypertonic saline on neurological status and brain edema in a rat model of closed head trauma combined with uncontrolled hemorrhage and concurrent resuscitation in rats. Anesth Analg 92:669-675
17. Shackford SR (1997) Effect of small-volume resuscitation on intracranial pressure and related cerebral variables. J Trauma 42:S48-S53
18. Cooper DJ, Myles PS, McDermott FT, Murray LJ, Laidlaw J, Cooper G, Tremayne AB, Bernard SS, Ponsford J (2004) Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial. JAMA 291:1350-1357
19. Salim A, Hadjizacharia P, Dubose J, Brown C, Inaba K, Chan LS, Margulies D (2009) Persistent hyperglycemia in severe traumatic brain injury: an independent predictor of outcome. Am Surg 75:25-29
20. Ritter AM, Robertson CS, Goodman JC, Contant CF, Grossman RG (1996) Evaluation of a carbohydrate-free diet for patients with severe head injury. J Neurotrauma 13:473-485
21. Katayama M, Hiraide A, Sugimoto H, Yoshioka T, Sugimoto T (1994) Effect of ketone bodies on hyperglycemia and lactic acidemia in hemorrhagic stress. JPEN J Parenter Enteral Nutr 18:442-446
22. Kammula RG (1976) Metabolism of ketone bodies by ovine brain in vivo. Am J Physiol 231:1490-1494
23. Hawkins RA (1971) Uptake of ketone bodies by rat brain in vivo. Biochem J 121:17P
24. Miles JM, Nissen SL, Rizza RA, Gerich JE, Haymond MW (1983) Failure of infused beta-hydroxybutyrate to decrease proteolysis in man. Diabetes 32:197-205
25. Arvidsson S, Haggendal E, Wins o I (1981) Effects on cerebral blood flow of infusion of hyperosmolar saline during cerebral vasodilation in the dog. Acta Anaesthesiol Scand 25:153-157
26. Schrock H, Kuschinsky W (1989) Cerebrospinal fluid ionic regulation, cerebral blood flow, and glucose use during chronic metabolic alkalosis. Am J Physiol 257:H1220-H1227
27. Pannier JL, Demeester G, Leusen I (1974) The influence of nonrespiratory alkalosis on cerebral blood flow in cats. Stroke 5:324-329
28. Giffard RG, Weiss JH, Choi DW (1992) Extracellular alkalinity exacerbates injury of cultured cortical neurons. Stroke 23:1817-1821
29. Bourdeaux CP, Brown JM (2011) Randomized controlled trial comparing the effect of 8.4% sodium bicarbonate and 5% sodium chloride on raised intracranial pressure after traumatic brain injury. Neurocrit Care 15:42-45
30. Kamel H, Navi BB, Nakagawa K, Hemphill JC 3rd, Ko NU (2011) Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials. Crit Care Med 39:554-559
31. Cottenceau V, Masson F, Mahamid E, Petit L, Shik V, Sztark F, Zaaroor M, Soustiel JF (2011) Comparison of effects of equiosmolar doses of mannitol and hypertonic saline on cerebral blood flow and metabolism in traumatic brain injury. J Neurotrauma 28:2003-2012
32. Ware ML, Nemani VM, Meeker M, Lee C, Morabito DJ, Manley GT (2005) Effects of 23.4% sodium chloride solution in reducing intracranial pressure in patients with traumatic brain injury: a preliminary study. Neurosurgery 57:727-736 discussion 727-736
33. White H, Venkatesh B (2011) Clinical review: ketones and brain injury. Crit Care 15:219