Mesenchymal stem cells utilize CXCR4-SDF-1 signaling for acute, but not chronic, trafficking to gastric mucosal inflammation

Digestive Diseases and Sciences

Volumn 58, Issue 9, 2013, Pages 2466-2477

  Stoicov, Calin ^a   Li, Hanchen ^a   Liu, Jian Hua ^a   Houghton, Jeanmarie ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

CXCR4; Gastric cancer; Helicobacter; Mesenchymal stem cells; SDF 1

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; STROMAL CELL DERIVED FACTOR 1; ALCOHOL; CXCR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CARCINOGENESIS; CELL CULTURE; CELL DIFFERENTIATION; CELL HOMING; CELL LINEAGE; CELL MIGRATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GASTRITIS; HELICOBACTER; HELICOBACTER FELIS; HELICOBACTER INFECTION; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; STOMACH EPITHELIUM; STOMACH MUCOSA; UPREGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; COMPLICATION; CYTOLOGY; EPITHELIUM CELL; MESENCHYMAL STROMA CELL; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; STOMACH; STOMACH NEOPLASMS;

ANIMALS; CELL DIFFERENTIATION; EPITHELIAL CELLS; ETHANOL; GASTRITIS; HELICOBACTER FELIS; HELICOBACTER INFECTIONS; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; STOMACH; STOMACH NEOPLASMS;

EID: 84884203793     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-013-2782-y     Document Type: Article

References (33)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74-108.
2. Stoicov C, Saffari R, Cai X, Hasyagar C, Houghton J. Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling Gene. 2004;341:1-17.
3. Gold JS, Jaques DP, Bentrem DJ, et al. Outcome of patients with known metastatic gastric cancer undergoing resection with therapeutic intent. Ann Surg Oncol. 2007;14:365-372.
4. Cai X, Carlson J, Stoicov C, Li H, Wang TC, Houghton J. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology. 2005;128:1937-1952.
5. Stoicov C, Li H, Cerny J, Houghton JM. How the study of Helicobacter infection can contribute to the understanding of carcinoma development. Clin Microbiol Infect. 2009;15:813-822.
6. IARC Working Group. Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994 IARC Monogr Eval Carcinog Risks Hum 1994;61:1-241.
7. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674.
8. Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer. 2008;8:755-768.
9. Spaeth EL, Dembinski JL, Sasser AK, et al. Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One. 2009;4:e4992.
10. Mishra PJ, Humeniuk R, Medina DJ, et al. Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res. 2008;68:4331-4339.
11. Bergfeld SA, DeClerck YA. Bone marrow-derived mesenchymal stem cells and the tumor microenvironment. Cancer Metastasis Rev. 2010;29:249-261.
12. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med. 1996;184:1101-1109.
13. Luster AD. Chemokines-chemotactic cytokines that mediate inflammation N. Engl J Med. 1998;338:436-445.
14. Hamm HE. The many faces of G protein signaling. J Biol Chem. 1998;273:669-672.
15. Cubedo N, Cerdan E, Sapede D, Rossel M. CXCR4 and CXCR7 cooperate during tangential migration of facial motoneurons. Mol Cell Neurosci. 2009;40:474-484.
16. Mazzinghi B, Ronconi E, Lazzeri E, et al. Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells. J Exp Med. 2008;205:479-490.
17. Dubeykovskaya Z, Dubeykovskiy A, Solal-Cohen J, Wang TC. Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J Biol Chem. 2009;284:3650-3662.
18. Domanska UM, Kruizinga RC, Nagengast WB, et al. A review on CXCR4/CXCL12 axis in oncology: No place to hide. Eur J Cancer. 2012;49:219-230.
19. Kwak MK, Hur K, Park DJ, et al. Expression of chemokine receptors in human gastric cancer. Tumour Biol. 2005;26:65-70.
20. Yasumoto K, Koizumi K, Kawashima A, et al. Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res. 2006;66:2181-2187.
21. Balkwill F. Cancer and the chemokine network. Nat Rev Cancer. 2004;4:540-550.
22. Houghton J, Stoicov C, Nomura S, et al. Gastric cancer originating from bone marrow-derived cells. Science. 2004;306:1568-1571.
23. Ohmae T, Hirata Y, Maeda S, et al. Helicobacter pylori activates NF-kappaB via the alternative pathway in B lymphocytes. J Immunol. 2005;175:7162-7169.
24. Zhao BC, Wang ZJ, Mao WZ, et al. CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma. World J Gastroenterol. 2011;17:2389-2396.
25. Varon C, Dubus P, Mazurier F, et al. Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice. Gastroenterology. 2012;142:281-291.
26. Li H, Fan X, Kovi RC, et al. Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice. Cancer Res. 2007;67:10889-10898.
27. Andrade MC, Menezes JS, Cassali GD, Martins-Filho OA, Cara DC, Faria AM. Alcohol-induced gastritis prevents oral tolerance induction in mice Clin. Exp Immunol. 2006;146:312-322.
28. Wynn RF, Hart CA, Corradi-Perini C, et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood. 2004;104:2643-2645.
29. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418:41-49.
30. Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res. 2002;62:3603-3608.
31. Dhar K, Dhar G, Majumder M, et al. Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1. Mol Cancer. 2010;9:209.
32. Chavakis E, Urbich C, Dimmeler S. Homing and engraftment of progenitor cells: a prerequisite for cell therapy. J Mol Cell Cardiol. 2008;45:514-522.
33. Ries C, Egea V, Karow M, Kolb H, Jochum M, Neth P. MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines. Blood. 2007;109:4055-4063.