Iron Deposition following Chronic Myocardial Infarction as a Substrate for Cardiac Electrical Anomalies: Initial Findings in a Canine Model

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Cokic, Ivan ^a   Kali, Avinash ^a,b,c   Wang, Xunzhang ^a   Yang, Hsin Jung ^a,c   Tang, Richard L Q ^a,f   Thajudeen, Anees ^a   Shehata, Michael ^a   Amorn, Allen M ^a   Liu, Enzhao ^a   Stewart, Brian ^d   Bennett, Nathan ^d   Harlev, Doron ^d   Tsaftaris, Sotirios A ^b,e,f   Jackman, Warren M ^g   Chugh, Sumeet S ^a,c   Dharmakumar, Rohan ^a,b,c,f  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b Northwestern University   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Rhythmia Medical Inc   (United States)

^e IMT SCHOOL FOR ADVANCED STUDIES LUCCA   (Italy)

^f NORTHWESTERN UNIVERSITY   (United States)

^g UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DOG; ELECTRIC CAPACITANCE; ELECTROCARDIOGRAM; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; EX VIVO STUDY; HEART ARRHYTHMIA; HEART INFARCTION; HEART LEFT VENTRICLE VOLUME; HEART RATE; IN VIVO STUDY; IRON STORAGE; MASS SPECTROMETRY; NONHUMAN; QT DISPERSION; QT INTERVAL;

ANIMALS; DOGS; ELECTRIC CAPACITANCE; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; IRON; MAGNETIC RESONANCE IMAGING; MYOCARDIAL INFARCTION;

EID: 84884194786     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073193     Document Type: Article

References (52)

1. Issa ZF, Miller JM, Zipes DP (2012) Clinical arrhythmology and electrophysiology: a companion to Braunwald's heart disease. Philadelphia, Pa; London: Saunders.
2. Shenasa M (2013) Cardiac mapping. ChichesterWest Sussex; HobokenNJ: Wiley-Blackwell. xx, 945 p.
3. de Bakker JM, van Capelle FJ, Janse MJ, Wilde AA, Coronel R, et al. (1988) Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: electrophysiologic and anatomic correlation. Circulation 77: 589-606.
4. de Bakker JM, Coronel R, Tasseron S, Wilde AA, Opthof T, et al. (1990) Ventricular tachycardia in the infarcted, Langendorff-perfused human heart: role of the arrangement of surviving cardiac fibers. J Am Coll Cardiol 15: 1594-1607.
5. Cinca J, Bardaji A, Carreno A, Mont L, Bosch R, et al. (1995) ST segment elevation at the surface of a healed transmural myocardial infarction in pigs. Conditions for passive transmission from the ischemic peri-infarction zone. Circulation 91: 1552-1559.
6. Cinca J, Warren M, Rodriguez-Sinovas A, Tresanchez M, Carreno A, et al. (1998) Passive transmission of ischemic ST segment changes in low electrical resistance myocardial infarct scar in the pig. Cardiovasc Res 40: 103-112.
7. Tucker HS Jr, Moss LF, Williams JP, (1948) Hemochromatosis with death from heart failure. Am Heart J 35: 993-1000.
8. Buja LM, Roberts WC, (1971) Iron in the heart. Etiology and clinical significance. Am J Med 51: 209-221.
9. Engle MA, (1964) Cardiac Involvement in Cooley's Anemia. Ann N Y Acad Sci 119: 694-702.
10. Carpenter JP, He T, Kirk P, Roughton M, Anderson LJ, et al. (2011) On T2* magnetic resonance and cardiac iron. Circulation 123: 1519-1528.
11. Hildebrand AM, Bhagirath KM, Ariyarajah V, Walker JR, Houston DS, et al. (2009) Myocardial siderosis due to hemochromatosis in an individual with hypertrophic cardiomyopathy. Can J Cardiol 25: e424-425.
12. Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, et al. (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106: 1460-1465.
13. Kaye SB, Owen M, (1978) Cardiac arrhythmias in thalassaemia major: evaluation of chelation treatment using ambulatory monitoring. Br Med J 1: 342.
14. Schwartz KA, Li Z, Schwartz DE, Cooper TG, Braselton WE, (2002) Earliest cardiac toxicity induced by iron overload selectively inhibits electrical conduction. J Appl Physiol 93: 746-751.
15. Kirk P, Roughton M, Porter JB, Walker JM, Tanner MA, et al. (2009) Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation 120: 1961-1968.
16. Isma'eel H, Shamseddeen W, Taher A, Gharzuddine W, Dimassi A, et al. (2009) Ventricular late potentials among thalassemia patients. Int J Cardiol 132: 453-455.
17. Jackowski C, Schwendener N, Grabherr S, Persson A (2013) Postmortem cardiac 3T magnetic resonance imaging: Visualizing the sudden cardiac death? J Am Coll Cardiol.
18. Jackowski C, Christe A, Sonnenschein M, Aghayev E, Thali MJ, (2006) Postmortem unenhanced magnetic resonance imaging of myocardial infarction in correlation to histological infarction age characterization. Eur Heart J 27: 2459-2467.
19. Tsuda N (1991) Electronic conduction in oxides. Berlin; London: Springer-Verlag. x, 323 p.
20. Gabriel C, Peyman A, Grant EH, (2009) Electrical conductivity of tissue at frequencies below 1 MHz. Phys Med Biol 54: 4863-4878.
21. Kofod G, Risse S, Stoyanov H, McCarthy DN, Sokolov S, et al. (2011) Broad-spectrum enhancement of polymer composite dielectric constant at ultralow volume fractions of silica-supported copper nanoparticles. ACS Nano 5: 1623-1629.
22. Wang J, Profitt JA, Pugia MJ, Suni II, (2006) Au nanoparticle conjugation for impedance and capacitance signal amplification in biosensors. Anal Chem 78: 1769-1773.
23. Kali A, Kumar A, Cokic I, Tang RL, Tsaftaris SA, et al. (2013) Chronic manifestation of postreperfusion intramyocardial hemorrhage as regional iron deposition: a cardiovascular magnetic resonance study with ex vivo validation. Circ Cardiovasc Imaging 6: 218-228.
24. Fishbein MC, Meerbaum S, Rit J, Lando U, Kanmatsuse K, et al. (1981) Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique. Am Heart J 101: 593-600.
25. Schwan HP (1963) 'Determination of biological impedances' in Nastuk WL: 'Physical techniques in biological research, vol. 6 (Electrophysiological Methods, Part B) p. 323-408.
26. Schwartzman D, Chang I, Michele JJ, Mirotznik MS, Foster KR, (1999) Electrical impedance properties of normal and chronically infarcted left ventricular myocardium. J Interv Card Electrophysiol 3: 213-224.
27. Schwan HP, Kay CF, (1957) The conductivity of living tissues. Ann N Y Acad Sci 65: 1007-1013.
28. Grimnes S, Martinsen RGT (2008) Bioimpedance and bioelectricity basics. Oxford: Elsevier/Academic. xi, 471 p.
29. Ahnve S, (1985) Correction of the QT interval for heart rate: review of different formulas and the use of Bazett's formula in myocardial infarction. Am Heart J 109: 568-574.
30. Bondarenko O, Beek AM, Hofman MB, Kuhl HP, Twisk JW, et al. (2005) Standardizing the definition of hyperenhancement in the quantitative assessment of infarct size and myocardial viability using delayed contrast-enhanced CMR. J Cardiovasc Magn Reson 7: 481-485.
31. Kumar A, Green JD, Sykes JM, Ephrat P, Carson JJ, et al. (2011) Detection and quantification of myocardial reperfusion hemorrhage using T2*-weighted CMR. JACC Cardiovasc Imaging 4: 1274-1283.
32. O'Regan DP, Ariff B, Neuwirth C, Tan Y, Durighel G, et al. (2010) Assessment of severe reperfusion injury with T2* cardiac MRI in patients with acute myocardial infarction. Heart 96: 1885-1891.
33. Gupta S, Desjardins B, Baman T, Ilg K, Good E, et al. (2012) Delayed-enhanced MR scar imaging and intraprocedural registration into an electroanatomical mapping system in post-infarction patients. JACC Cardiovasc Imaging 5: 207-210.
34. Kocovic DZ, Harada T, Friedman PL, Stevenson WG, (1999) Characteristics of electrograms recorded at reentry circuit sites and bystanders during ventricular tachycardia after myocardial infarction. J Am Coll Cardiol 34: 381-388.
35. Saito J, Downar E, Doig JC, Masse S, Sevaptsidis E, et al. (1998) Characteristics of local electrograms with diastolic potentials: identification of different components of return pathways in ventricular tachycardia. J Interv Card Electrophysiol 2: 235-245.
36. Cabo C, Schmitt H, Masters G, Coromilas J, Wit AL, et al. (1998) Location of diastolic potentials in reentrant circuits causing sustained ventricular tachycardia in the infarcted canine heart: relationship to predicted critical ablation sites. Circulation 98: 2598-2607.
37. Scott PA, Morgan JM, Carroll N, Murday DC, Roberts PR, et al. (2011) The extent of left ventricular scar quantified by late gadolinium enhancement MRI is associated with spontaneous ventricular arrhythmias in patients with coronary artery disease and implantable cardioverter-defibrillators. Circ Arrhythm Electrophysiol 4: 324-330.
38. Scott PA, Rosengarten JA, Shahed A, Yue AM, Murday DC, et al. (2013) The relationship between left ventricular scar and ventricular repolarization in patients with coronary artery disease: insights from late gadolinium enhancement magnetic resonance imaging. Europace 15: 899-906.
39. Kirschvink JL, Kobayashi-Kirschvink A, Diaz-Ricci JC, Kirschvink SJ (1992) Magnetite in human tissues: a mechanism for the biological effects of weak ELF magnetic fields. Bioelectromagnetics Suppl 1: 101-113.
40. Jackson JD (1999) Classical electrodynamics. New York: Wiley. xxi, 808 p.
41. Yi G, Guo XH, Reardon M, Gallagher MM, Hnatkova K, et al. (1998) Circadian variation of the QT interval in patients with sudden cardiac death after myocardial infarction. Am J Cardiol 81: 950-956.
42. Straus SM, Kors JA, De Bruin ML, van der Hooft CS, Hofman A, et al. (2006) Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 47: 362-367.
43. Kulbertus H (1977) Re-entrant arrhythmias: mechanisms and treatment. Lancaster, [Eng.]: MTP Press. x, 372 p.
44. Josephson ME, Horowitz LN, Farshidi A, (1978) Continuous local electrical activity. A mechanism of recurrent ventricular tachycardia. Circulation 57: 659-665.
45. Simson MB, Euler D, Michelson EL, Falcone RA, Spear JF, et al. (1981) Detection of delayed ventricular activation on the body surface in dogs. Am J Physiol 241: H363-369.
46. el-Sherif N, Gomes JA, Restivo M, Mehra R, (1985) Late potentials and arrhythmogenesis. Pacing Clin Electrophysiol 8: 440-462.
47. Nakahara S, Vaseghi M, Ramirez RJ, Fonseca CG, Lai CK, et al. (2011) Characterization of myocardial scars: electrophysiological imaging correlates in a porcine infarct model. Heart Rhythm 8: 1060-1067.
48. Klem I, Weinsaft JW, Bahnson TD, Hegland D, Kim HW, et al. (2012) Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation. J Am Coll Cardiol 60: 408-420.
49. Dawson DK, Hawlisch K, Prescott G, Roussin I, Di Pietro E, et al. (2013) Prognostic role of CMR in patients presenting with ventricular arrhythmias. JACC Cardiovasc Imaging 6: 335-344.
50. Boye P, Abdel-Aty H, Zacharzowsky U, Bohl S, Schwenke C, et al. (2011) Prediction of life-threatening arrhythmic events in patients with chronic myocardial infarction by contrast-enhanced CMR. JACC Cardiovasc Imaging 4: 871-879.
51. Miller JM, Kienzle MG, Harken AH, Josephson ME, (1984) Subendocardial resection for ventricular tachycardia: predictors of surgical success. Circulation 70: 624-631.
52. Miller JM, Tyson GS, Hargrove WC 3rd, Vassallo JA, Rosenthal ME, et al. (1995) Effect of subendocardial resection on sinus rhythm endocardial electrogram abnormalities. Circulation 91: 2385-2391.