Earliest cardiac toxicity induced by iron overload selectively inhibits electrical conduction

Journal of Applied Physiology

Volumn 93, Issue 2, 2002, Pages 746-751

  Schwartz, Kenneth A ^a   Li, Zy ^a   Schwartz, Dianne E ^a   Cooper, Thomas G ^b   Emmett Braselton, W ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

Author keywords

Arrhythmia; Cardiomyopathy; Electrophysiology; Sudden death

Indexed keywords

IRON DEXTRAN; IRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; FEMALE; GUINEA PIG; HEART ARRHYTHMIA; HEART CONDUCTION; HEART LEFT VENTRICLE CONTRACTILITY; HEART MUSCLE CONTRACTILITY; HEART PAPILLARY MUSCLE; IRON OVERLOAD; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PURKINJE FIBER; SUDDEN DEATH; ANIMAL; CARDIOMYOPATHY; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART MUSCLE CONDUCTION SYSTEM; LIVER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ARRHYTHMIA; CARDIOMYOPATHIES; DEATH, SUDDEN, CARDIAC; ELECTRIC CONDUCTIVITY; FEMALE; GUINEA PIGS; HEART CONDUCTION SYSTEM; IRON; IRON OVERLOAD; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MYOCARDIUM; VENTRICULAR FUNCTION, LEFT;

EID: 0036021847     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01144.2001     Document Type: Article

References (32)

1. Iron-induced myocardial and hepatic lysosomal abnormalities in the guinea pig
2. Magnetic resonance imaging in idiopathic hemochromatosis
3. Efficacy of deferoxamine in preventing complications of iron loaded in patients with thalassemia major
4. Iron in the heart: Etiology and clinical significance
5. A unique rodent model for both the cardiotoxic and hepatotoxic effects of prolonged iron overload
6. Hereditary hemochromatosis: Phenotypic expression of the disease
7. Hepatic iron stores and markers of iron loaded in alcoholics and patients with idiopathic hemochromatosis
8. Hepatic iron overload: Diagnosis and quantification by noninvasive imaging
9. Cardiac abnormalties in primary hemochromatosis
10. Longitudinal study of cardiac function in thalassemia major
11. The detection of iron overload
12. Cardiac involvement in secondary haemochromatosis: A catheter biopsy study and analysis of mycocardium
13. Chelation therapy in alphathalassemia: The benefits and limitations of desferrioxamine
14. Overdrive suppression of conduction at the canine Purkinje-muscle junction
15. Purkinkje-muscle coupling and endocardial response to hyperkalemia, hypokalemia and acidosis
16. Dynamics of circus movement re-entry across canine Purkinje fiber-muscle junctions
17. Hepatic iron overload: Quantitative MR imaging
18. Severity of iron overload in patients with sickle cell disease receiving chronic red blood cell transfusion therapy
19. Evaluation of tranfusional iron overload before and during iron chelation by magnetic resonance imaging of the liver and determination of serum ferritin in adult non-thalassaemic patients
20. Non-invasive quantitation of liver iron overloaded by magnetic resonance imaging
21. Cardiac arrhythmias in thalassaemia major: Evaluation of chelation treatment using ambulatory monitoring
22. Decreased sodium and increased transient outward potassium currents in iron-loaded cardiac myocytes
23. Iron, free radicals, and oxidative injury
24. Idiopathic hemochromatosis an interim report
25. Electrophysiological derangements induced by lipid peroxidation in cardiac tissure
26. Liver iron stores in patients with secondary haemosiderosis under iron chelation therapy with deferoxamine or deferiprone
27. Evaluation of cardiac function in patients with thalassemia major
28. Survival in medically treated patients with homozygous-α thalassemia
29. Continuous subcutaneous administration of deferoxamine in patients with iron overload
30. Morphologic investigation of the guinea pig model of iron overload
31. Histochemical studies of the myocardium and conduction system in acquired iron-storage disease
32. Multielement assays of bovine tissue specimens by inductively coupled argon plasma emission spectroscopy