HDAC9 gene is associated with stroke risk in a Chinese population

Experimental Biology and Medicine

Volumn 238, Issue 7, 2013, Pages 842-847

  Han, Yan ^a   Sun, Wenzhu ^b   Wang, Li ^c   Tao, Sha ^c   Tian, Lu ^c   Hao, Yong ^a   Zhang, Wei ^d,e   Wu, Shuai ^a   Li, Shixu ^a   Lv, Huihui ^a   Zheng, S Lilly ^c   Sun, Jielin ^c   Xu, Jianfeng ^b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d CHINESE PLA GENERAL HOSPITAL   (China)

^e Beijing 307 Hospital   (China)

Author keywords

Chinese; HDAC9; ischaemic; large vessel; SNP; stroke

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE 9; UNCLASSIFIED DRUG;

AGED; ALLELE; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM;

CHINESE; HDAC9; ISCHAEMIC; LARGE VESSEL; SNP; STROKE;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CHROMOSOME MAPPING; DEMOGRAPHY; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HISTONE DEACETYLASES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRESSOR PROTEINS; RISK FACTORS; STROKE;

EID: 84884180602     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370213494650     Document Type: Article

References (15)

1. Singh RB,Suh I,Singh VP,Chaithiraphan S,Laothavorn P,Sy RG,Babilonia NA,Rahman ARA,Sheikh S,Tomlinson B,Sarraf-Zadigan N.Hypertension and stroke in Asia: prevalence, control and strategies in developing countries for prevention.J Hum Hypertens. 2000;14:749-63.
2. Liao DP,Myers R,Hunt S,Shahar E,Paton C,Burke G,Province M,Heiss G.Familial history of stroke and stroke risk - The Family Heart Study.Stroke. 1997;28:1908-12.
3. Bejot Y,Benatru I,Rouaud O,Fromont A,Besancenot JP,Moreau T,Giroud M.Epidemiology of stroke in Europe: geographic and environmental differences.J Neurol Sci. 2007;262:85-8.
4. Bellenguez C,Bevan S,Gschwendtner A,Spencer CCA,Burgess AI,Pirinen M,Jackson CA,Traylor M,Strange A,Su Z,Band G,Syme PD,Malik R,Pera J,Norrving B,Lemmens R,Freeman C,Schanz R,James T,Poole D,Murphy L,Segal H,Cortellini L,Cheng Y-C,Woo D,Nalls MA,Mueller-Myhsok B,Meisinger C,Seedorf U,Ross-Adams H,Boonen S,Wloch-Kopec D,Valant V,Slark J,Furie K,Delavaran H,Langford C,Deloukas P,Edkins S,Hunt S,Gray E,Dronov S,Peltonen L,Gretarsdottir S,Thorleifsson G,Thorsteinsdottir U,Stefansson K,Boncoraglio GB,Parati EA,Attia J,Holliday E,Levi C,Franzosi M-G,Goel A,Helgadottir A,Blackwell JM,Bramon E,Brown MA,Casas JP,Corvin A,Duncanson A,Jankowski J,Mathew CG,Palmer CNA,Plomin R,Rautanen A,Sawcer SJ,Trembath RC,Viswanathan AC,Wood NW,Worrall BB,Kittner SJ,Mitchell BD,Kissela B,Meschia JF,Thijs V,Lindgren A,Macleod MJ,Slowik A,Walters M,Rosand J,Sharma P,Farrall M,Sudlow CLM,Rothwell PM,Dichgans M,Donnelly P,Markus HS,Isgc, Wtccc.Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.Nat Genet. 2012;44:328-33.
5. Jerrard-Dunne P,Cloud G,Hassan A,Markus HS.Evaluating the genetic component of ischemic stroke subtypes - A family history study.Stroke. 2003;34:1364-9.
6. Liu J,Cheng J,Peng J,Han S,Yu L,Nie S.Effects of polymorphisms of heat shock protein 70 gene on ischemic stroke, and interaction with smoking in China.Clin Chim Acta. 2007;384:64-8.
7. Jia Q,Liu L,Wang Y.Risk factors and prevention of stroke in the Chinese Population.J Stroke Cerebrovasc Dis. 2011;20:395-400.
8. Barrett JC,Fry B,Maller J,Daly MJ.Haploview: analysis and visualization of LD and haplotype maps.Bioinformatics. 2005;21:263-5.
9. Purcell S,Neale B,Todd-Brown K,Thomas L,Ferreira MAR,Bender D,Maller J,Sklar P,de Bakker PIW,Daly MJ,Sham PC.PLINK: a tool set for whole-genome association and population-based linkage analyses.Am J Hum Genet. 2007;81:559-75.
10. Bertos NR,Wang AH,Yang XJ.Class II histone deacetylases: structure, function, and regulation.Biochem Cell Biol-Biochim Biol Cell. 2001;79:243-52.
11. Antos CL,McKinsey TA,Dreitz M,Hollingsworth LM,Zhang CL,Schreiber K,Rindt H,Gorczynski RJ,Olson EN.Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors.J Biol Chem. 2003;278:28930-7.
12. Zhang CL,McKinsey TA,Chang SR,Antos CL,Hill JA,Olson EN.Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy.Cell. 2002;110:479-88.
13. Chang SR,McKinsey TA,Zhang CL,Richardson JA,Hill JA,Olson EN.Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.Mol Cell Biol. 2004;24:8467-76.
14. Zhou XB,Marks PA,Rifkind RA,Richon VM.Cloning and characterization of a histone deacetylase, HDAC9.Proc Natl Acad Sci U S A. 2001;98:10572-7.
15. Mejat A,Ramond F,Bassel-Duby R,Khochbin S,Olson EN,Schaeffer L.Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression.Nat Neurosci. 2005;8:313-21.