Alcohol use biomarkers predicting cognitive performance: A secondary analysis in veterans with alcohol dependence and posttraumatic stress disorder

Military Medicine

Volumn 178, Issue 9, 2013, Pages 974-980

  Kalapatapu, Raj K ^a,b   Delucchi, Kevin L ^a   Lasher, Brooke A ^b,c   Vinogradov, Sophia ^a,b,c   Batki, Steven L ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CARBOHYDRATE DEFICIENT TRANSFERRIN; CARBOHYDRATE-DEFICIENT TRANSFERRIN; DIETHYL SULFATE; DRUG DERIVATIVE; ETHYL GLUCURONIDE; GAMMA GLUTAMYLTRANSFERASE; GLUCURONIC ACID; SULFATE; TRANSFERRIN;

ADULT; AGED; ALCOHOLISM; ARTICLE; BLOOD; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MEAN CORPUSCULAR VOLUME; METABOLISM; MIDDLE AGED; POSTTRAUMATIC STRESS DISORDER; PREDICTIVE VALUE; PSYCHOLOGIC TEST; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; RANDOMIZED CONTROLLED TRIAL; VETERAN;

ADULT; AGED; ALANINE TRANSAMINASE; ALCOHOLISM; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; COGNITION; ERYTHROCYTE INDICES; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; GLUCURONATES; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOLOGICAL TESTS; STRESS DISORDERS, POST-TRAUMATIC; SULFURIC ACID ESTERS; TRANSFERRIN; VETERANS;

EID: 84884162970     PISSN: 00264075     EISSN: 1930613X     Source Type: Journal    
DOI: 10.7205/MILMED-D-13-00097     Document Type: Article

References (62)

1. Rehm J: The risks associated with alcohol use and alcoholism. Alcohol Res Health 2011; 34(2): 135-43.
2. National Institute on Drug Abuse. Substance Abuse among the Military, Veterans, and their Families. April 2011. Available at http://www.drugabuse.gov/sites/default/files/veterans.pdf; accessed April 16, 2013.
3. Brust JC: Ethanol and cognition: indirect effects, neurotoxicity and neuroprotection: a review. Int J Environ Res Public Health 2010; 7(4): 1540-57.
4. Field M, Schoenmakers T, Wiers RW: Cognitive processes in alcohol binges: a review and research agenda. Curr Drug Abuse Rev 2008; 1(3): 263-79.
5. Stavro K, Pelletier J, Potvin S: Widespread and sustained cognitive deficits in alcoholism: a meta-analysis. Addict Biol 2013; 18(2): 203-13.
6. Noel X, Sferrazza R, Van Der Linden M, et al: Contribution of frontal cerebral blood flow measured by (99m)Tc-Bicisate spect and executive function deficits to predicting treatment outcome in alcoholdependent patients. Alcohol Alcohol 2002; 37(4): 347-54.
7. Dick DM, Smith G, Olausson P, et al: Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addict Biol 2010; 15(2): 217-26.
8. Wain RM, Wilbourne PL, Harris KW, et al: Motivational interview improves treatment entry in homeless veterans. Drug Alcohol Depend 2011; 115 (1-2): 113-9.
9. Stetter F, Ackermann K, Bizer A, Straube ER, Mann K: Effects of disease-related cues in alcoholic inpatients: results of a controlled "Alcohol Stroop" study. Alcohol Clin Exp Res 1995; 19(3): 593-9.
10. Moore SC, Cusens B: Delay discounting predicts increase in blood alcohol level in social drinkers. Psychiatry Res 2010; 179(3): 324-7.
11. Smith DE, McCrady BS: Cognitive impairment among alcoholics: impact on drink refusal skill acquisition and treatment outcome. Addict Behav 1991; 16(5): 265-4.
12. Fals-Stewart W: Ability to counselors to detect cognitive impairment among substance-abusing patients: an examination of diagnostic efficiency. Exp Clin Psychopharmacol 1997; 5(1): 39-50.
13. Schrimsher GW, Parker JD, Burke RS: Relation between cognitive testing performance and pattern of substance use in males at treatment entry. Clin Neuropsychol 2007; 21(3): 498-510.
14. Horner MD, Harvey RT, Denier CA: Self-report and objective measures of cognitive deficit in patients entering substance abuse treatment. Psychiatry Res 1999; 86(2): 155-61.
15. Shelton MD, Parsons OA: Alcoholics' self-assessment of their neuropsychological functioning in everyday life. J Clin Psychol 1987; 43(3): 395-403.
16. Copersino ML, Fals-Stewart W, Fitzmaurice G, Schretlen DJ, Sokoloff J, Weiss RD: Rapid cognitive screening of patients with substance use disorders. Exp Clin Psychopharmacol 2009; 17(5): 337-44.
17. Bates ME, Labouvie EW, Voelbel GT: Individual differences in latent neuropsychological abilities at addictions treatment entry. Psychol Addict Behav 2002; 16(1): 35-46.
18. Copersino ML, Schretlen DJ, Fitzmaurice GM, et al: Effects of cognitive impairment on substance abuse treatment attendance: predictive validation of a brief cognitive screening measure. Am J Drug Alcohol Abuse 2012; 38(3): 246-50.
19. Substance Abuse and Mental Health Services Administration. The Role of Biomarkers in the Treatment of Alcohol Use Disorders, 2012 Revision. Advisory 2012; 11(2). Available at http://www.kap.samhsa.gov/products/manuals/advisory/pdfs/Advisory_Biomarkers_Revision.pdf; accessed April 16, 2013.
20. Kalapatapu RK, Chambers R: Novel objective biomarkers of alcohol use: potential diagnostic and treatment management tools in dual diagnosis care. J Dual Diagn 2009; 5(1): 57-82.
21. Schafer K, Butters N, Smith T, et al: Cognitive performance of alcoholics: a longitudinal evaluation of the role of drinking history, depression, liver function, nutrition, and family history. Alcohol Clin Exp Res 1991; 15(4): 653-60.
22. Arria AM, Tarter RE, Kabene MA, Laird SB, Moss H, Van Thiel DH: The role of cirrhosis in memory functioning of alcoholics. Alcohol Clin Exp Res 1991; 15(6): 932-7.
23. Shah S, Weed HG, He X, Agrawal A, Ozer E, Schuller DE: Alcoholrelated predictors of delirium after major head and neck cancer surgery. Arch Otolaryngol Head Neck Surg 2012; 138(3): 266-71.
24. Irwin M, Smith TL, Butters N, et al: Graded neuropsychological impairment and elevated gamma-glutamyl transferase in chronic alcoholic men. Alcohol Clin Exp Res 1989; 13(1): 99-103.
25. van Thriel C, Zupanic M, Sietmann B, Demes P, Willer H, Seeber A: Association of biochemical and subjective indicators of drinking habits with performance on different neurobehavioral tasks. Neurotoxicology 1998; 19(4/5): 713-20.
26. Richardson ED, Malloy PF, Longabaugh R, Williams J, Noel N, Beattie MC: Liver function tests and neuropsychologic impairment in substance abusers. Addict Behav 1991; 16(1/2): 51-5.
27. Junghanns K, Backhaus J, Veltrup C, Dageforde J, Bruckmann H, Wetterling T: Mildly disturbed hepatic and pancreatic function during early abstention from alcohol is associated with brain atrophy and with disturbed psychometric performance. Alcohol Alcohol 2004; 39(2): 113-8.
28. Everett PS: The relationship between cognitive function and liver function in alcoholism. Br J Psychiatry 1984; 144: 521-4.
29. Fals-Stewart W, Bates ME: The neuropsychological test performance of drug-abusing patients: an examination of latent cognitive abilities and associated risk factors. Exp Clin Psychopharmacol 2003; 11(1): 34-45.
30. Ingall GB: Alcohol biomarkers. Clin Lab Med 2012; 32(3): 391-406.
31. Wurst FM, Schuttler R, Kempter C, et al: Can ethyl glucuronide be determined in post-mortem body fluids and tissues? Alcohol Alcohol 1999; 34(2): 262-3.
32. Fontana A, Rosenheck R, Desai R: Comparison of treatment outcomes for veterans with posttraumatic stress disorder with and without comorbid substance use/dependence. J Psychiatr Res 2012; 46(8): 1008-14.
33. McCauley JL, Killeen T, Gros DF, Brady KT, Back SE: Posttraumatic stress disorder and co-occurring substance use disorders: advances in assessment and treatment. Clin Psychol Sci Prac 2012; 19(3): 283-304.
34. Carter AC, Capone C, Short EE: Co-occurring posttraumatic stress disorder and alcohol use disorders in veteran populations. J Dual Diagn 2011; 7(4): 285-99.
35. Jacobsen LK, Southwick SM, Kosten TR: Substance use disorders in patients with posttraumatic stress disorder: a review of the literature. Am J Psychiatry 2001; 158(8): 1184-90.
36. National Institute on Alcohol Abuse and Alcoholism (NIAAA). Helping Patients Who Drink Too Much: A Clinician's Guide. National Institutes of Health 2007; Publication No. 07-3769. NIAAA Publications. Available at http://pubs.niaaa.nih.gov/publications/Practitioner/CliniciansGuide2005/guide.pdf; accessed April 16, 2013.
37. Pettinati HM, Weiss RD, Miller WR, Donovan D, Ernst DB, Rounsaville BJ: COMBINE Monograph Series, Volume 2. Medical Management Treatment Manual: A Clinical Research Guide for Medically Trained Clinicians Providing Pharmacotherapy as Part of the Treatment for Alcohol Dependence. Bethesda, MD: DHHS, NIAAA, 2004; Vol. 04-5289. NIAAA Publications. Available at http://pubs.niaaa.nih.gov/publications/combine/Combine%202.pdf; accessed April 16, 2013
38. First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P). New York, Biometrics Research, New York State Psychiatric Institute, 2002.
39. Sobell LC, Maisto SA, Sobell MB, Cooper AM: Reliability of alcohol abusers' self-reports of drinking behavior. Behavi Res Ther 1979; 17(2): 157-60.
40. Blake DD, Weathers FW, Nagy LM, et al: The development of a Clinician-Administered PTSD Scale. J Trauma Stress 1995; 8(1): 75-90.
41. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J: An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561-71.
42. Tombaugh TN: Trail Making Test A and B: normative data stratified by age and education. Arch Clin Neuropsychol 2004; 19(2): 203-14.
43. Brandt J: The Hopkins Verbal Learning Test: development of a new memory test with six equivalent forms. Clin Neuropsychol 1991; 5(2): 125-42.
44. Lejuez CW, Read JP, Kahler CW, et al: Evaluation of a behavioral measure of risk taking: the Balloon Analogue Risk Task (BART). J Exp Psychol Appl 2002; 8(2): 75-84.
45. Kirby KN, Petry NM, Bickel WK: Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen 1999; 128(1); 78-87.
46. Gotlib IH, Joormann J: Cognition and depression: current status and future directions. Annu Rev Clin Psychol 2010; 6: 285-312.
47. Qureshi SU, Long ME, Bradshaw MR, et al: Does PTSD impair cognition beyond the effect of trauma? J Neuropsychiatry Clin Neurosci 2011; 23(1): 16-28.
48. Bowen JD, Larson EB: Drug-induced cognitive impairment. Defining the problem and finding solutions. Drugs Aging 1993; 3(4): 349-57.
49. Field A: Regression. In: Discovering Statistics Using SPSS, Ed 3, pp 197-263. London, Sage, 2009.
50. de Bruin EA, Lemmens PH, Hulshoff Pol HE, Verbaten MN, Kenemans JL: Relationship between carbohydrate-deficient transferrin, gamma-glutamyl transferase, and mean corpuscular volume levels and alcohol-related brain volume decreases in male drinkers. Hum Psychopharmacol 2012; 27(6): 559-65.
51. Chen CH, Walker J, Momenan R, Rawlings R, Heilig M, Hommer DW: Relationship between liver function and brain shrinkage in patients with alcohol dependence. Alcohol Clin Exp Res 2012; 36(4): 625-32.
52. Yavuz BB, Yavuz B, Halil M, et al: Serum elevated gamma glutamyl-transferase levels may be a marker for oxidative stress in Alzheimer's disease. Int Psychogeriatr 2008; 20(4): 815-23.
53. Tarter RE, Moss H, Arria A, Van Thiel D: Hepatic, nutritional, and genetic influences on cognitive process in alcoholics. NIDA Res Monogr 1990; 101: 124-35.
54. Danon D, Bologna NB, Gavendo S: Memory performance of young and old subjects related to their erythrocyte characteristics. Exp Gerontol 1992; 27(3); 275-85.
55. Pfefferbaum A, Rosenbloom M, Crusan K, Jernigan TL: Brain CT changes in alcoholics: effects of age and alcohol consumption. Alcohol Clin Exp Res 1988; 12(1); 81-7.
56. Maes M, Van Der Planken M, Van Gastel A, et al: Influence of academic examination stress on hematological measurements in subjectively healthy volunteers. Psychiatry Res 1998; 80(3): 201-12.
57. Subramanian S, Elango T, Malligarjunan H, Kochupillai V, Dayalan H: Role of sudarshan kriya and pranayam on lipid profile and blood cell parameters during exam stress: a randomized controlled trial. Int J Yoga 2012; 5(1): 21-7.
58. Walton NH, Bowden SC: Does liver dysfunction explain neuropsychological status in recently detoxified alcohol-dependent clients? Alcohol Alcohol 1997; 32(3): 287-95.
59. O'Mahony JF: Cognitive performance and liver function among recently abstinent alcohol abusers. Addict Behav 2005; 30(2): 369-73.
60. Cohen J: The cost of dichotomization. Appl Psychol Meas 1983; 7(3): 249-53.
61. MacCallum RC, Zhang S, Preacher KJ, Rucker DD: On the practice of dichotomization of quantitative variables. Psychol Methods 2002; 7(1): 19-40.
62. Altman DG, Royston P: The cost of dichotomising continuous variables. BMJ 2006; 332(7549): 1080.