Combined PET/MR imaging in neurology: MR-based attenuation correction implies a strong spatial bias when ignoring bone

NeuroImage

Volumn 84, Issue , 2014, Pages 206-216

  Andersen, Flemming Littrup ^a   Ladefoged, Claes Nøhr ^a   Beyer, Thomas ^a,b   Keller, Sune Høgild ^a   Hansen, Adam Espe ^a   Højgaard, Liselotte ^a   Kjær, Andreas ^a   Law, Ian ^a   Holm, Søren ^a  

^a Rigshospitalet   (Denmark)

^b cmi experts GmbH   (Switzerland)

Author keywords

Attenuation correction; Image reconstruction; Neurology; PET MR; Positron Emission Tomography

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; ARTICLE; BASAL GANGLION; CLINICAL ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DEMENTIA; FEMALE; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; IMAGE RECONSTRUCTION; MALE; PHANTOM; PRIORITY JOURNAL; SKULL; WHOLE BODY MRI; WHOLE BODY PET; ARTIFACT; BRAIN; IMAGE ENHANCEMENT; MIDDLE AGED; MULTIMODAL IMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; POSITRON EMISSION TOMOGRAPHY; PROCEDURES; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ARTIFACTS; BRAIN; DEMENTIA; FEMALE; HUMANS; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIMODAL IMAGING; POSITRON-EMISSION TOMOGRAPHY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SKULL;

EID: 84884139383     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2013.08.042     Document Type: Article

References (34)

1. Andersen F.L., Keller S.H., Hansen A.E., Beyer T., Law I., Højgaard L., Holm S. Bone attenuation in brain-PET/MR imaging should be accounted for during attenuation correction and PET reconstruction. Eur. J. Nucl. Med. Mol. Imaging 2012, 39(2):174.
2. Beyer T., Freudenberg L.S., Czernin J., Townsend D.W. The future of hybrid imaging-part 3: PET/MR, small-animal imaging and beyond. Insights Imaging 2011, 2(3):235-246.
3. Bezrukov I., Mantlik F., Schmidt H., Schölkopf B., Pichler B.J. MR-based PET attenuation correction for PET/MR imaging. Semin. Nucl. Med. 2013, 43(1):45-59.
4. Budinger T.F. Time-of-flight positron emission tomography: status relative to conventional PET. J. Nucl. Med. 1983, 24(1):73-78.
5. Burger C., Goerres G., Schoenes S., Buck A., Lonn A.H., Von Schulthess G.K. PET attenuation coefficients from CT images: experimental evaluation of the transformation of CT into PET 511-keV attenuation coefficients. Eur. J. Nucl. Med. Mol. Imaging 2002, 29(7):922-927.
6. Carney J.P., Townsend D.W., Rappoport V., Bendriem B. Method for transforming CT images for attenuation correction in PET/CT imaging. Med. Phys. 2006, 33(4):976-983.
7. Catana C., van der Kouwe A., Benner T., Michel C.J., Hamm M., Fenchel M., Fischl B., Rosen B., Schmand M., Sorensen A.G. Towards implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype. J. Nucl. Med. 2010, 51(9):1431-1438.
8. Catana C., Drzezga A., Heiss W.D., Rosen B.R. PET/MRI for neurologic applications. J. Nucl. Med. 2012, 53(12):1916-1925.
9. Clark C.M., Pontecorvo M.J., Beach T.G., Bedell B.J., Coleman R.E., Doraiswamy P.M., Fleisher A.S., Reiman E.M., Sabbagh M.N., Sadowsky C.H., Schneider J.A., Arora A., Carpenter A.P., Flitter M.L., Joshi A.D., Krautkramer M.J., Lu M., Mintun M.A., Skovronsky D.M., AV-45-A16 Study Group Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study. Lancet Neurol. 2012, 11(8):669-678.
10. Delso G., Fürst S., Jakoby B., Ladebeck R., Ganter C., Nekolla S.G., Schwaiger M., Ziegler S.I. Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner. J. Nucl. Med. 2011, 52:1914-1922.
11. Hasselbalch S.G., Knudsen G.M., Videbaek C., Pinborg L.H., Schmidt J.F., Holm S., Paulson O.B. No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 1999, 48(10):1915-1921.
12. Heiss W.D. The potential of PET/MR for brain imaging. Eur. J. Nucl. Med. Mol. Imaging 2009, 36(1):105-112.
13. Hitz S., Habekost C., Delso G., Souvatzoglou M., Grimmer T., Beer A., Fürst S., Ziegler S., Schwaiger M., Drzezga A. Evaluation of the qualitative performance of PET/MR versus PET/CT in patients with Alzheimer's disease. J. Nucl. Med. 2012, 53(1):1932.
14. Hitz S., Habekost C., Fürst S., Delso G., Föster S., Ziegler S., Nekolla G., Souvatzoglou M., Beer A., Grimmer T., Schwaiger M., Drzezga A. Qualitative performance of an integrated whole-body PET/MR scanner for brain imaging: systematic comparison to conventional PET/CT inpatients examined for suspected dementia with [18F]FDG. J. Nucl. Med. 2013, (in review).
15. Hofmann M., Pichler B., Schölkopf B., Beyer T. Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques. Eur. J. Nucl. Med. Mol. Imaging 2009, 39(1):93-104.
16. Huang S.C., Hoffman E.J., Phelps M.E., Kuhl D.E. Quantitation in positron emission computed tomography: 2. Effects of inaccurate attenuation correction. J. Comput. Assist. Tomogr. 1979, 3(6):804-814.
17. Jakoby B.W., Bercier Y., Conti M., Casey M.E., Bendriem B., Townsend D.W. Physical and clinical performance of the mCT time-of-flight PET/CT scanner. Phys. Med. Biol. 2011, 56(8):2375-2389.
18. Kalemis A., Delattre B.M., Heinzer S. Sequential whole-body PET/MR scanner: concept, clinical use, and optimisation after two years in the clinic. The manufacturer's perspective. MAGMA 2013, 26(1):5-23.
19. Keereman V., Mollet P., Berker Y., Schulz V., Vandenberghe S. Challenges and current methods for attenuation correction in PET/MR. MAGMA 2013, 26(1):81-98.
20. Keller S.H., Holm S., Hansen A.E., Sattler B., Andersen F., Klausen T.L., Højgaard L., Kjær A., Beyer T. Image artifacts from MR-based attenuation correction in clinical, whole-body PET/MRI. MAGMA 2013, 26(1):173-181.
21. Kinahan P.E., Townsend D.W., Beyer T., Sashin D. Attenuation correction for a combined 3D PET/CT scanner. Med. Phys. 1998, 25:2046-2053.
22. Krak N.C., van der Hoeven J.J., Hoekstra O.S., Twisk J.W., van der Wall E., Lammertsma A.A. Measuring [(18)F]FDG uptake in breast cancer during chemotherapy: comparison of analytical methods. Eur. J. Nucl. Med. Mol. Imaging 2003, 30(5):674-681.
23. LaCroix K.J., Tsui B.M.W., Hasegawa B.H., Brown J.K. Investigation of the use of X-ray CT images for attenuation compensation in SPECT. IEEE Trans. Nucl. Sci. 1994, 41(6):2793-2799.
24. Martinez-Möller A., Souvatzoglou M., Delso G., Bundschuh R.A., Chefd'hotel C., Ziegler S.I., Navab N., Schwaiger M., Nekolla S.G. Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J. Nucl. Med. 2009, 50:520-526.
25. Ostrowitzki S., Deptula D., Thurfjell L., et al. Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab. Arch. Neurol. 2011, 69(2):198-207.
26. Pauleit D., Floeth F., Hamacher K., et al. O-(2-[18F]fluoroethyl)-L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas. Brain 2005, 128:678-687.
27. Pichler B.J., Kolb A., Nägele T., Schlemmer H.P. PET/MRI: paving the way for the next generation of clinical multimodality imaging applications. J. Nucl. Med. 2010, 51(3):333-336.
28. Schulz V., Torres-Espallardo I., Renisch S., Hu Z., Ojha N., Börnert P., Perkuhn M., Niendorf T., Schäfer W.M., Brockmann H., Krohn T., Buhl A., Günther R.W., Mottaghy F.M., Krombach G.A. Automatic, three-segment, MR-based attenuation correction for whole-body PET/MR data. Eur. J. Nucl. Med. Mol. Imaging 2011, 38:138-152.
29. Silverman D.H. Brain 18FFDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging. J. Nucl. Med. 2004, 45(4):594-607.
30. Spence A.M., Muzi M., Mankoff D.A., O'Sullivan S.F., Link J.M., Lewellen T.K., Lewellen B., Pham P., Minoshima S., Swanson K., Krohn K.A. 18F-FDG PET of gliomas at delayed intervals: improved distinction between tumor and normal gray matter. J. Nucl. Med. 2004, 45(10):1653-1659.
31. Wagenknecht G., Kaiser H.J., Mottaghy F.M., Herzog H. MRI for attenuation correction in PET: methods and challenges. MAGMA 2013, 26(1):99-113.
32. Wahl R.L., Quint L.E., Cieslak R.D., Aisen A.M., Koeppe R.A., Meyer C.R. "Anatometabolic" tumor imaging: fusion of FDG PET with CT or MRI to localize foci of increased activity. J. Nucl. Med. 1993, 34(7):1190-1197.
33. Watson C.C. A technique for measuring the energy response of a PET tomograph using a compact scattering source. IEEE Trans. Nucl. Sci. 1997, 44(6):2500-2508.
34. Zaidi H., Ojha N., Morich M., Griesmer J., Hu Z., Maniawski P., Ratib O., Izquierdo-Garcia D., Fayad Z., Shao L. Design and performance evaluation of a whole-body ingenuity TF PET-MRI system. Phys. Med. Biol. 2011, 56:3091-3106.