Radioimmunotherapy of Cryptococcus neoformans spares bystander mammalian cells

Future Microbiology

Volumn 8, Issue 9, 2013, Pages 1081-1089

  Bryan, Ruth A ^a   Jiang, Zewei ^a   Morgenstern, Alfred ^b   Bruchertseifer, Frank ^b   Casadevall, Arturo ^a   Dadachova, Ekaterina ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b JOINT RESEARCH CENTRE   (Italy)

Author keywords

bystander effects; Cryptococcus neoformans; fungal infection; NO production; particulate radiation; radioimmunotherapy

Indexed keywords

ANTIBODY; BISMUTH 213; CRYSTAL VIOLET; LACTATE DEHYDROGENASE; RHENIUM 188; TETRAZOLIUM;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CHINESE HAMSTER; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; ENVIRONMENTAL EXPOSURE; MACROPHAGE; MAMMAL CELL; MEMBRANE BIOLOGY; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOTHERAPY;

ANIMALS; CELL LINE; CELL SURVIVAL; CRICETINAE; CRICETULUS; CRYPTOCOCCUS NEOFORMANS; GENTIAN VIOLET; L-LACTATE DEHYDROGENASE; MICE; NITRIC OXIDE; RADIOIMMUNOTHERAPY; TETRAZOLIUM SALTS;

EID: 84884124932     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.13.79     Document Type: Article

References (17)

1. Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23(4), 525-530 (2009).
2. Sun HY, Alexander BD, Lortholary O et al. Unrecognized pretransplant and donor-derived cryptococcal disease in organ transplant recipients. Clin. Infect. Dis. 51(9), 1062-1069 (2010).
3. Filler SG, Sheppard DC. Fungal invasion of normally non-phagocytic host cells. PLoS Pathog. 2(12), e129 (2006).
4. Dadachova, E, Casadevall A. Radioimmunotherapy of infectious diseases. Semin. Nucl. Med. 39(2), 146-153 (2009).
5. Dadachova E, Nakouzi A, Bryan RA, Casadevall A. Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection. Proc. Natl Acad. Sci. USA 100(19), 10942-10947 (2003).
6. Jiang Z, Bryan RA, Morgenstern A, Bruchertseifer F, Casadevall A, Dadachova E. Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice. Antimicrob. Agents Chemother. 56(1), 552-554 (2012).
7. Bryan RA, Jiang Z, Huang X et al. Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells. Antimicrob. Agents Chemother. 53(4), 1679-1682 (2009).
8. Casadevall A, Cleare W, Feldmesser M et al. Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies. Antimicrob. Agents Chemother. 42(6), 1437-1446 (1998).
9. Alvarez M, Casadevall A. Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages. BMC Immunol. 8, 16 (2007).
10. Rivera J, Mukherjee J, Weiss LM, Casadevall A. Antibody efficacy in murine pulmonary Cryptococcus neoformans infection: a role for nitric oxide. J. Immunol. 168(7), 3419-3427 (2002).
11. Granger DL, Hibbs JB Jr, Broadnax LM. Urinary nitrate excretion in relation to murine macrophage activation: influence of dietary l-arginine and oral NG-monomethyl-l-arginine. J. Immunol. 146(4), 1294-1302 (1991).
12. Schweitzer AD, Howell RC, Jiang Z et al. Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors. PLoS ONE 4(9), e7229 (2009).
13. Martinez LR, Bryan RA, Apostolidis C, Morgenstern A, Casadevall A, Dadachova E. Antibody-guided alpha radiation effectively damages fungal biofilms. Antimicrob. Agents Chemother. 50(6), 2132-2136 (2006).
14. Bryan RA, Jiang Z, Howell RC et al. Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection. J. Infect. Dis. 202(4), 633-637 (2010).
15. Dadachova E, Bryan RA, Frenkel A et al. Evaluation of acute hematological and long-term pulmonary toxicity of radio-immunotherapy of Cryptococcus neoformans infection in murine models. Antimicrob. Agents Chemother. 48(3), 1004-1006 (2004).
16. Dadachova E, Howell RW, Bryan RA, Frenkel A, Nosanchuk JD, Casadevall A. Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioimmunotherapy with alpha-and beta-emitting radioisotopes. J. Nucl. Med. 45(2), 313-320 (2004).
17. Bryan RA, Huang X, Morgenstern A, Bruchertseifer F, Casadevall A, Dadachova E. Radio-fungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans. Antimicrob. Agents Chemother. 52(6), 2232-2235 (2008).