Measurement of Single Protein Molecules Using Digital ELISA

The Immunoassay Handbook

Volumn , Issue , 2013, Pages 223-242

  Rissin, David M ^a   Wilson, David H ^a   Duffy, David C ^a  

^a QUANTERIX CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84883951376     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-08-097037-0.00016-6     Document Type: Chapter

References (33)

1. Armani A.M., Kulkarni R.P., Fraser S.E., Flagan R.C., Vahala K.J. Label-free, single-molecule detection with optical microcavities. Science 2007, 317:783-787.
2. Bartels E.M., Wätjen I., Andersen E., Danneskiold-Samsøe B., Bliddal H., Ribel-Madsen S. Rheumatoid factor and its interference with cytokine measurements: problems and solutions. Arthritis 2011, 2011:741071.
3. Chang L., Rissin D.M., Fournier D.F., Piech T., Patel P.P., Wilson D.H., Duffy D.C. Single molecule enzyme-linked immunosorbent assays: theoretical considerations. J. Immunol. Meth. 2012, 378:102-115.
4. Chang L., Song L., Fournier D.R., Kan C.W., Patel P.P., Ferrell E.P., Pink B.A., Minnehan K.A., Hanlon D.W., Duffy D.C., Wilson D.H. Simple diffusion-constrained immunoassay for p24 protein with the sensitivity of nucleic acid amplification for detecting acute HIV infection. J Virol Methods 2012 Oct 2, pii: S0166-0934(12)00296-0. doi: 10.1016/j.jviromet.2012.08.017. [Epub ahead of print].
5. Clinical Laboratory Standards Institute. Evaluation of the Linearity of Quantitative Measurement Procedure: A Statistical Approach; Approved Guideline. 2nd edn. CLSI Document EP6-A, 2003.
6. Clinical Laboratory Standards Institute. Evaluation of Precision Performance of Quantitative Measurement Methods; Approved Guideline. 2nd edn. CLSI Document EP5-A2, 2004.
7. Craig D.B., Arriaga E.A., Wong J.C.Y., Lu H., Dovichi N.J. Studies on single alkaline phosphatase molecules: reaction rate and activation energy of a reaction catalyzed by a single molecule and the effect of thermal denaturation-the death of an enzyme. J. Am. Chem. Soc. 1996, 118:5245-5253.
8. Davies C. Introduction to immunoassay principles. The Immunoassay Handbook 2005, 3-37. Elsevier Ltd, Oxford. 3rd edn. D. Wild (Ed.).
9. Ferguson R.A., Yu H., Kalyvas M., Zammit S., Diamandis E.P. Ultrasensitive detection of prostate-specific antigen by a time-resolved immunofluorometric assay and the immulite immunochemiluminescent third-generation assay: potential applications in prostate and breast cancers. Clin. Chem. 1996, 42:675-684.
10. Gorris H.H., Rissin D.M., Walt D.R. Stochastic inhibitor release and binding from single-enzyme molecules. Proc. Nat. Acad. Sci. 2007, 104:17680-17685.
11. Hermanson G.T. Bioconjugate Techniques 2008, Academic Press. 2nd edn.
12. Kan C.W., Rivnak A.J., Campbell T.G., Piech T., Rissin D.M., Mösl M., Peterça A., Niederberger H.P., Minnehan K.A., Patel P.P., Ferrell E.P., Meyer R.E., Chang L., Wilson D.H., Fournier D.R., Duffy D.C. Isolation and detection of single molecules on paramagnetic beads using sequential fluid flows in microfabricated polymer array assemblies. Lab. Chip 2012, 12:987-995.
13. Karlsson R., Michaelsson A., Mattsson L. Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. J. Immunol. Methods 1991, 145:229-240.
14. Kourilov V., Steinitz M. Magnetic-bead enzyme-linked immunosorbent assay verifies adsorption of ligand and epitope accessibility. Anal. Biochem. 2002, 311:166-170.
15. Kricka L.J. Human anti-animal antibody interference in immunological assays. Clin. Chem. 1999, 45:942-956.
16. Kuhn K., Baker S.C., Chudin E., Lieu M.H., Oeser S., Bennett H., Rigault P., Barker D., McDaniel T.K., Chee M.S. A novel, high-performance random array platform for quantitative gene expression profiling. Genome Res. 2004, 14:2347-2356.
17. Lepor H., Cheli C.D., Thiel R.P., Taneja S.S., Laze J., Chan D.W., Sokoll L.J., Mangold L., Partin A.W. Clinical evaluation of a novel method for the measurement of prostate-specific antigen, AccuPSA(TM), as a predictor of 5-year biochemical recurrence-free survival after radical prostatectomy: results of a pilot study. BJU Int. 2011, Oct 12, doi: 10.1111/j.1464-410X.2011.10568.x.
18. Nalefski E.A., D'Antoni C.M., Ferrell E.P., Lloyd J.A., Qiu H., Harris J.L., Whitney D.H. Single-molecule detection for femtomolar quantification of proteins in heterogeneous immunoassays. Clin. Chem. 2006, 52:2172-2175.
19. Pantano P., Walt D.R. Ordered Nanowell arrays. Chem. Mater. 1996, 8:2832-2835.
20. Randall J., Mörtberg E., Provuncher G.K., Fournier D.R., Duffy D.C., Rubertsson S., Blennow K., Zetterberg H., Wilson D.H. Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: Results of a pilot study. Resuscitation 2012 Aug 9, [Epub ahead of print].
21. Rissin D.M., Walt D.R. Digital concentration readout of single enzyme molecules using femtoliter arrays and Poisson statistics. Nano Lett. 2006, 6:520-523.
22. Rissin D.M., Walt D.R. Digital readout of target binding with attomole detection limits via enzyme amplification in femtoliter arrays. J. Am. Chem. Soc. 2006, 128:6286-6287.
23. Rissin D.M., Kan C.W., Campbell T.G., Howes S.C., Fournier D.R., Song L., Piech T., Patel P.P., Chang L., Rivnak A.J., Ferrell E.P., Randall J.D., Provuncher G.K., Walt D.R., Duffy D.C. Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nat. Biotechnol. 2010, 28:595-599.
24. Rissin D.M., Fournier D.R., Piech T., Kan C.W., Campbell T.G., Song L., Chang L., Rivnak A.J., Patel P.P., Provuncher G.K., Ferrell E.P., Howes S.C., Pink B.A., Minnehan K.A., Wilson D.H., Duffy D.C. Simultaneous detection of single molecules and singulated ensembles of molecules enables immunoassays with broad dynamic range. Anal. Chem. 2011, 83:2279-2285.
25. Rondelez Y., Tresset G., Tabata K.V., Arata H., Fujita H., Takeuchi S., Noji H. Microfabricated arrays of femtoliter chambers allow single molecule enzymology. Nat. Biotechnol. 2005, 23:361-365.
26. Selby C. Interference in immunoassay. Ann. Clin. Biochem. 1999, 36:704-721.
27. Song L., Hanlon D.W., Chang L., Provuncher G.K., Kan C.W., Campbell T.G., Fournier D.R., Ferrell E.P., Rivnak A.J., Pink B.A., Minnehan K.A., Patel P.P., Wilson D.H., Till M.A., Faubion W.A., Duffy D.C. Single molecule measurements of tumor necrosis factor α and interleukin-6 in the plasma of patients with Crohn's disease. J. Immunol. Methods 2011, 372:177-186.
28. Tessler L.A., Reifenberger J.G., Mitra R.D. Protein quantification in complex mixtures by solid phase single-molecule counting. Anal. Chem. 2009, 81:7141-7148.
29. Todd J., Freese B., Lu A., Held D., Morey J., Livingston R., Goix P. Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem. 2007, 53:1990-1995.
30. Wilson D.H., Hanlon D.W., Provuncher G.K., Chang L., Song L., Patel P.P., Ferrell E.P., Lepor H., Partin A.W., Chan D.W., Sokoll L.J., Cheli C.D., Thiel R.P., Fournier D.R., Duffy D.C. Fifth-generation digital immunoassay for prostate-specific antigen by single molecule array technology. Clin. Chem. 2011, 57:1712-1721.
31. Wood W.G. "Matrix effects" in immunoassays. Scand. J. Clin. Lab. Invest. Suppl. 1991, 205:105-112.
32. Xue Q., Yeung E.S. Differences in the chemical reactivity of individual molecules of an enzyme. Nature 1995, 373:681-683.
33. Zetterberg H., Mortberg E., Song L., Chang L., Provuncher G.K., Patel P.P., Ferrell E.P., Fournier D.R., Kan C.W., Campbell T.G., Meyer R., Rivnak A.J., Pink B.A., Minnehan K.A., Piech T., Rissin D.M., Duffy D.C., Rubertsson S., Wilson D.H., Blennow K. Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans. PLoS One 2011, 6(12):e28263.