Neurocognitive function in HIV-positive children in a developing country

International Journal of Infectious Diseases

Volumn 17, Issue 10, 2013, Pages

  Walker, S Y ^a   Pierre, R B ^a,b   Christie, C D C ^a,b   Chang, S M ^c  

^a UNIVERSITY OF THE WEST INDIES   (Jamaica)

^b Jamaica Paediatric   (Jamaica)

^c UNIVERSITY OF THE WEST INDIES   (Jamaica)

Author keywords

Encephalopathy; HAART; HIV; Jamaica; Neurocognitive; Pediatric

Indexed keywords

ANTIRETROVIRUS AGENT;

ADOLESCENT; ADULT; ARTICLE; ATAXIA; ATTENTION; AUDITORY MEMORY; BEHAVIOR DISORDER; CHILD; CHILD DEVELOPMENT; CLINICAL ASSESSMENT; COGNITION; COGNITIVE DEFECT; COGNITIVE DEVELOPMENT; COHORT ANALYSIS; CONTROLLED STUDY; COORDINATION; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; HYPERREFLEXIA; INFANT; INTELLIGENCE; JAMAICA; LEARNING DISORDER; MAJOR CLINICAL STUDY; MALE; MICROCEPHALY; MOTOR PERFORMANCE; NEWBORN; OUTCOME ASSESSMENT; PARALYSIS; PRESCHOOL CHILD; QUADRIPLEGIA; SCHOOL CHILD; SELECTIVE ATTENTION; SHORT TERM MEMORY; SPASTICITY; SPATIAL MEMORY;

ENCEPHALOPATHY; HAART; HIV; JAMAICA; NEUROCOGNITIVE; PEDIATRIC;

AIDS DEMENTIA COMPLEX; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COGNITION DISORDERS; DEVELOPING COUNTRIES; HUMANS; INFANT; JAMAICA; LEARNING DISORDERS; MEMORY DISORDERS; MICROCEPHALY; PREVALENCE; QUALITY OF LIFE; REFLEX, ABNORMAL;

EID: 84883808633     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2013.02.014     Document Type: Article

References (46)

1. The World Bank. Databank for Jamaica. Available at: (accessed November 22, 2011). http://data.worldbank.org/country/jamaica.
2. Ministry of Health, Jamaica. HIV/AIDS report 2009. Jamaica: Monitoring and Evaluation Unit, National HIV/STI Programme; 2009.
3. Safrit J., Wilfert C. Pediatric and perinatal HIV/AIDS in Jamaica. West Indian Med J 2004, 53:217-365.
4. Vermund S., Krogstad P. Pediatric and perinatal HIV/AIDS in Jamaica. West Indian Med J 2008, 57:187-320.
5. Epstein L., Sharer L., Joshi V.V., Fojas M.M., Koenisberger M.R., Oleske J.M. Progressive encephalopathy in children with AIDS. Ann Neurol 1985, 17:488-496.
6. Belman A.L., Diamond G., Dickson D., Horoupian D., Llena J., Lantos G., et al. Pediatric acquired immunodeficiency syndrome: neurologic syndromes. Am J Dis Child 1988, 142:29-35.
7. Hamid M.Z., Aziz N.A., Zulkifli Z.S., Norlijah O., Azhar R.K. Clinical features and risk factors for HIV encephalopathy in children. Southeast Asian J Trop Med Public Health 2008, 39:266-272.
8. Blanche S., Newell M., Mayaux M.J., Dunn D.T., Teglas J.P., Rouzioux C., et al. Morbidity and mortality in European children vertically infected by HIV-1. The French Pediatric HIV Infection Study Group and European Collaborative Study. J AIDS Hum Retrovirol 1997, 14:442-450.
9. Lobato M.N., Caldwell M.B., Ng P., Oxtoby M.J. Encephalopathy in children with perinatally acquired human immunodeficiency virus infection. J Pediatr 1995, 126:710-715.
10. Tardieu M., Le Chenadec J., Persoz A., Meyer L., Blanche S., Mayaux M. HIV-1 encephalopathy in infants compared with children and adults. French pediatric HIV infection study and the SEROCO group. Neurology 2000, 54:1089-1095.
11. Mintz M. Clinical comparison of adult and pediatric NeuroAIDS. Adv Neuroimmunol 1994, 4:207-221.
12. Chase C., Vibbert M., Pelton S.I., Coulter D.L., Cabral H. Early neurodevelopmental growth in children with vertically transmitted human immunodeficiency virus infection. Arch Pediatr Adolesc Med 1995, 149:850-855.
13. Chase C., Ware J., Hittelman J., Blasini I., Smith R., Llorente A., et al. Early cognitive and motor development among infants born to women infected with human immunodeficiency virus. Pediatrics 2000, 106:E25.
14. Englund J.A., Baker C.J., Raskino C., McKinney R.E., Lifschitz M.H., Petrie B., et al. Clinical and laboratory characteristics of a large cohort of symptomatic, human immunodeficiency virus-infected infants and children. AIDS Clinical Trials Group Protocol 152 Study Team. Pediatr Infect Dis J 1996, 15:1025-1036.
15. McKinney R.E., Johnson G.M., Stanley K., Yong F.H., Yong M.S., Brouwers P., et al. A randomized study of combined zidovudine-lamivudine versus didanosine monotherapy in children with symptomatic therapy-naïve HIV-1 infection. J Pediatr 1998, 133:500-508.
16. Mayaux M.J., Burgard M., Tegals J.P., Cottalorda J., Krivine A., Simon F., et al. Neonatal characteristics in rapidly progressive perinatally acquired HIV-1 disease. JAMA 1996, 275:606-610.
17. Smith R., Malee K., Charurat M., Magder L., Mellins C., Macmillan C., et al. Timing of perinatal human immunodeficiency virus type 1 infection and rate of neurodevelopment. The Women and Infant Transmission Study Group. Pediatr Infect Dis J 2000, 19:862-871.
18. Chiriboga C., Fleishman S., Champion S., Gaye-Robinson L., Abrams E.J. Incidence and prevalence of HIV encephalopathy in children with HIV infection receiving highly active anti-retroviral therapy (HAART). J Pediatr 2005, 146:402-407.
19. Patel K., Ming X., Williams P.L., Robertson K.R., Oleske J.M., International Maternal Pediatric Adolescent AIDS Clinical Trials 219/219C Study Team, et al. Impact of HAART and CNS-penetrating antiretroviral regimens on HIV encephalopathy among perinatally infected children and adolescents. AIDS 2009, 23:1893-1901.
20. World Health Organization. Antiretroviral therapy of HIV infection in infants and children in resource-limited settings: towards universal access; recommendations for a public health approach: 2010 revision. Geneva: WHO; 2010. Available at: (accessed November 28, 2011). http://www.who.int/hiv/pub/paediatric/infants2010/en/index.html.
21. 1994 Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR Morb Mortal Wkly Rep 1994, 43(RR-12):1-10. Centers for Disease Control and Prevention.
22. Walker S.P., Chang S.M., Powell C.A., Simonoff E., Grantham-McGregor S.M. Effects of psychosocial stimulation and dietary supplementation in early childhood on psychosocial functioning in late adolescence: follow up of randomised controlled trial. BMJ 2006, 333(7566):472.
23. Chang S.M., Walker S.P., Grantham-McGregor S., Powell C.A. Early childhood stunting and later fine motor abilities. Dev Med Child Neurol 2010, 52:831-836.
24. Walker S.P., Chang S.M., Younger N., Grantham-McGregor S.M. The effect of psychosocial stimulation on cognition and behavior at 6 years in a cohort of term, low-birthweight Jamaican children. Dev Med Child Neurol 2010, 52(7):e148-e154. 10.1111/j.1469-8749.2010.03637.x.
25. Raven J., Raven J.C., Court J.H. Manual for Raven's Progressive Matrices and Vocabulary Scales 2003, Harcourt Assessment, San Antonio, TX.
26. Lezak M.D., Howieson D.B., Loring D.W. Neuropsychological assessment 2004, Oxford University Press, New York. 4th ed.
27. Orsini A., Grossi D., Schiappa O. Sex and cultural differences in children's spatial and verbal memory span. Percept Mot Skills 1981, 53:39-42.
28. Flanagan D.B., Kaufman A.S. Essentials of WISC-IV assessment 2004, John Wiley & Sons, Hoboken, NJ.
29. Strauss E., Sherman E., Spreen O. A compendium of neuropsychological tests: administration, norms, and commentary 1998, Oxford University Press, New York. 1st ed.
30. Manly T., Robertson I.H., Anderson V., Nimmo-Smith I. The Test of Everyday Attention for Children (TEA-Ch) 1999, Thames Valley Test Company, Bury St Edmunds, UK.
31. Manly T., Anderson V., Nimmo-Smith I., Turner A., Watson P., Robertson I.H. The differential assessment of children's attention: The Test of Everyday Attention for Children (TEA-Ch), normal sample and ADHD performance. J Child Psychol Psychiatry 2001, 42:1065-1081.
32. Henderson S.E., Sugden D.A. The movement ABC manual 1992, The Psychological Corporation, London, UK.
33. Tecklin J.S. Pediatric physical therapy 1998, Lippincott, Williams & Wilkins, Philadelphia, PA. 3rd ed.
34. Rourke B.P., Yanni D.W., MacDonald G.W., Young G.C. Neuropsychological significance of lateralized deficits on the grooved pegboard test for older children with learning disabilities. J Consult Clin Psychol 1973, 41:128-134.
35. Roeder M., Mahone E., Larson G., Mostofsky S.H., Laurie E. Left-right differences on timed motor examination in children. Child Neuropsychol 2008, 14:249-262.
36. Vitiello B., Ricciuti A., Stoff D.M., Behar D., Denckla M.B. Reliability of subtle (soft) neurological signs in children. J Am Acad Child Adolesc Psychiatry 1989, 28:749-753.
37. Schanbhag M., Rutstein R., Zaoutis T., Huaqing Z., Chao D., Radcliffe J. Neurocognitive functioning in pediatric human immunodeficiency virus infection. Arch Pediatr Adolesc Med 2005, 159:651-665.
38. Smith L., Adnams C., Eley B. Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy. SAJCH 2008, 2:108-113.
39. Rostasy M. Inflammation and neuroaxonal injury in multiple sclerosis and AIDS-dementia complex: implications for neuroprotective treatment. Neuropediatrics 2005, 36:230-239.
40. Wachtman L.M., Skolasky R.L., Tarwater P.M., Esposito D., Schifitto G., Marder K., et al. Platelet decline: an avenue for investigation into the pathogenesis of human immunodeficiency virus-associated dementia. Arch Neurol 2007, 64:1264-1272.
41. Price R.W., Yiannoutsos C., Clifford D.B., Zaborskib L., Tselis A., Sidtis J.J., et al. Neurological outcomes in late HIV infection: adverse impact of neurological impairment on survival and protective effect of antiviral therapy. AIDS 1999, 13:1677-1685.
42. Letendre S., Marquie-Beck J., Capparelli E., Best B., Clifford D., Collier A.C., et al. Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Ann Neurol 2008, 65:65-70.
43. Koekkoek S., de Sonneville L.M., Wolf T.F., Licht R., Geelen S.P. Neurocognitive function profile in HIV-infected school-age children. Eur J Pediatr Neurol 2008, 12:290-297.
44. Blanchette N., Smith M.L., King S., Fernandes-Penney A., Read S. Cognitive development in school-age children with vertically transmitted HIV infection. Dev Neuropsychol 2002, 21:223-241.
45. Violari A., Cotton M.F., Gibb D.M., Babiker A.G., Steyn J., Madhi S.A., et al. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med 2008, 359:2233-2244.
46. Van Rie A., Dow A., Mupuala A., Stewart P. Neurodevelopmental trajectory of HIV-infected children accessing care in Kinshasa, Democratic Republic of Congo. J Acquir Immune Defic Syndr 2009, 52(5):636-642. 10.1097/QAI.0b013e3181b32646.