Dental caries: A disease which remains a public health concern in the 21st Century-The exploration of a breakthrough technology for caries prevention

Journal of Clinical Dentistry

Volumn 24, Issue SPEC.ISS.A, 2013, Pages

  Cummins, D ^a  

^a Oral Care Research and Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICARIES AGENT; ARGININE; BICARBONATE; CALCIUM; FLUORIDE; PREBIOTIC AGENT;

ARTICLE; DENTAL CARIES; HUMAN; PUBLIC HEALTH; RISK FACTOR;

ARGININE; BICARBONATES; CALCIUM; CARIOSTATIC AGENTS; DENTAL CARIES; FLUORIDES; HUMANS; PREBIOTICS; PUBLIC HEALTH; RISK FACTORS;

EID: 84883802279     PISSN: 08958831     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (122)

1. Bowen WH. Do we need to be concerned about dental caries in the coming millennium? Crit Rev Oral Biol Med 2002; 13:126-31. (Pubitemid 34791213)
2. National Institutes of Health Consensus Development Panel. National institutes of health consensus development conference statement. Diagnosis and management of dental caries throughout life, March 26-28, 2001. J Am Dent Assoc 2001; 132:1153-61.
3. Taubman MA, Nash DA. The scientific and public-health imperative for a vaccine against dental caries. Nat Rev Immunol 2006;6:555-63. (Pubitemid 43980528)
4. Beltran-Aguilar ED, Beltran-Neira RJ. Oral disease and conditions throughout the lifespan. 1. Diseases and conditions directly associated with tooth loss. Gen Dent 2004;52:21-7. (Pubitemid 39118615)
5. Curzon MEJ, Preston AJ. Risk groups: nursing bottle caries/caries in the elderly. Caries Res 2004;38(Suppl 1):24-33. (Pubitemid 38056701)
6. Misra S, Tahmassebi JF, Brosnan M. Early childhood caries-a review. Dent Update 2007;34:556-64.
7. Anderson M. Risk assessment and epidemiology of dental caries: Review of the literature. Pediatr Dent 2002;24:377-85.
8. Thomson WM. Dental caries experience in older people over time: what can the large cohort studies tell us? Br Dent J 2004; 196:89-92. (Pubitemid 40348079)
9. Saunders RH Jr, Meyerowitz C. Dental caries in older adults. Dent Clin North Am 2005;49:293-308. (Pubitemid 40332302)
10. Cummins D. The impact of research and development on the prevention of oral diseases in children and adolescents: an industry perspective Pediatr Dent 2006;28:118-27.
11. Cummins D, Bowen WH. Biotechnology in oral care. In: Cosmetic Science and Technology Series, Volume 29, Biotech in Personal Care, Lad R, ed, Taylor and Francis, Ltd., New York, 2006; pp. 323-52.
12. Fejerskov O. Changing paradigms in concepts on dental caries: consequences for oral health care. Caries Res 2004;38:182-91. (Pubitemid 38716208)
13. Brambilla E, Garcia-Godoy F, Strohmenger L. Principles of diagnosis and treatment in high-caries-risk subjects. Dent Clin North Am 2000;44: 507-40.
14. Marsh PD. Dental plaque as a microbial biofilm. Caries Res 2004;38: 204-11. (Pubitemid 38716211)
15. ten Cate JM. Biofilms, a new approach to the microbiology of dental plaque. Odontology 2006;94:1-9. (Pubitemid 44463448)
16. Kuramitsu HK, He X, Lux R, Anderson M H, Shi W. Interspecies interactions within oral microbial communities. Microbiol Mol Biol Rev 2007;71:653-70. (Pubitemid 350309182)
17. Marsh PD. Dental plaque as a biofilm and a microbial community implications for health and disease. BMC Oral Health 2006; 15 (Suppl 1):S14.
18. Caufield PW, Griffen AL. Dental caries. An infection and transmissible disease. Pediatr Clin North Am 2000;47:1001-19.
19. Kidd EA, Fejerskov O. What constitutes dental caries? Histopathology of carious enamel and dentin related to the action of cariogenic biofilms. J Dent Res 2004;83(Spec No C):C35-8.
20. Featherstone JD. The caries balance: contributing factors and early detection. J Calif Dent Assoc 2003;31:129-33.
21. Featherstone JD. Caries prevention and reversal based on the caries balance. Pediatr Dent 2006;28:128-32.
22. Fontana M, Zero DT. Assessment of patients caries risk. J Am Dent Assoc 2006; 137:1231-9.
23. Kidd EA. Assessing caries risk. Dent Update 1998;5:385-90.
24. Reich E, Lussi A, Newbrun E. Caries-risk assessment. Int Dent J 1999; 49:15-26.
25. Pitts NB, Stamm JW International consensus workshop on caries clinical trials (ICW-CCT)-final consensus statements: Agreeing where the evidence leads. J Dent Res 2004;83(Spec No Q:C125-8.
26. Keyes PH. Research in dental caries. J Am Dent Assoc 1968;76: 1357-73.
27. Marsh PD. Dental plaque: biological significance of a biofilm and community life-style. J Clin Periodontal 2005;32(Suppl 6):7-15. (Pubitemid 41391052)
28. Marsh PD, Percival RS. The oral microflora friend or foe? Can we decide? Int Dent J 2006;56(Suppl 1):233-9. (Pubitemid 44338017)
29. Kleinberg I. The other side of confectionary use and dental caries. J Can Dent Assoc 1989;55:837-8.
30. Kleinberg I. New approaches for controlling dental plaque pathogenicity. NYState Dent J 1990;56:31-4.
31. Kleinberg I. A new saliva-based anti-caries composition. Dent Today 1999;18:98-103.
32. Arends J, Christoffersen J. The nature of early caries lesions in enamel. J Dent Res 1986;65:2-11.
33. Featherstone JD. Prevention and reversal of dental caries: Role of low level fluoride. Community Dent Oral Epidemiol 1999;27:31-40.
34. Pitts NB. Modern concepts of caries measurement. J Dent Res 2004;83(SpecNo C):C43-7.
35. Hicks J, Garcia-Godoy F, Donly K, Flaitz C. Fluoride-releasing restorative materials and secondary caries. Dent Clin North Am 2002;46:247-76.
36. Lynch E, Beighton D. A comparison of primary root caries lesions classified according to colour. Caries Res 1994;28:233-9.
37. Heijnsbroek M, Paraskevas S, van der Weijden GA. Fluoride interventions for root caries: A review. Oral Health Prev Dent 2007;5:145-52.
38. Whelton H. Overview of the impact of changing global patterns of dental caries experience on caries clinical trials. J Dent Res 2004;83(Spec NoC):C29-34.
39. Moynihan P, Petersen PE. Diet, nutrition and the prevention of dental diseases. Public Health Nutr 2004;7:201-26. (Pubitemid 38294518)
40. Dye BA, Tan S, Smith V, Lewis BG, Barker LK, Thornton-Evans G, Eke PI, Beltrjn-Aguilar ED, Horowitz AM, Li CH. Trends in oral health status: United States, 1988-1994 and 1999-2004. Vital Health Stat 2007;11:1-92.
41. Dental, oral and craniofacial resource center. Oral Health U.S., 2002. Bethesda, Maryland, 2002.
42. Bönecker M, Cleaton-Jones P. Trends in dental caries in Latin American and Caribbean 5-6-and 11-13-year-old children: A systematic review. Community Dent Oral Epidemiol 2003;31:152-7. (Pubitemid 37465456)
43. Vargas CM, Crall JJ, Schneider DA. Sociodemographic distribution of pediatric dental caries: NHANES III, 1988-1994. J Am Dent Assoc 1998;129:1229-38. (Pubitemid 128452838)
44. Pederson PE. World Oral Health Report, 2003. Geneva, Switzerland: World Health Organization, 2003. Available at:www.who.int/oral-health/ media/en/orh-report03-en.pdf.
45. Bratthall D, Hansel-Petersson G, Sundberg H. Reasons for the caries decline: What do the experts believe? Eur J Oral Sci 1996;104:416-22.
46. Diehnelt DE, Kiyak HA. Socioeconomic factors that affect international caries levels. Community Dent Oral Epidemiol 2001;29:226-33. (Pubitemid 33685760)
47. Speechley M, Johnston DW Some evidence from Ontario, Canada, of a reversal in the dental caries decline. Caries Res 1996;30:423-7. (Pubitemid 126461940)
48. Marthaler TM. Changes in dental caries 1953-2003. Caries Res 2004; 38:173-81. (Pubitemid 38716207)
49. Davies MJ, Spencer AJ, Slade GD. Trends in dental caries experience of school children in Australia-1977 to 1993. Aust Dent J 1997;42:389-94. (Pubitemid 127513766)
50. Andou Y. Oral health status in Japan. J Health Care Dent 2006;8:19-29.
51. Cleaton-Jones P, Fatti P, B necker M. Dental caries trends in 5-to 6-yearold and 11 -to 13-year-old children in three UNICEF designated regions Sub-Saharan Africa, Middle East and North Africa, Latin America and Caribbean: 1970-2004. Int Dent J 2006;56:294-300. (Pubitemid 44599243)
52. Fejerskov O, Baelum V, Luan WM, Manji F. Caries prevalence in Africa and the People's Republic of China. Int Dent J 1994;44(Suppl 1): 425-33.
53. Sembene M, Kane AW, Bourgeois D. Caries prevalence in 12-year-old schoolchildren in Senegal in 1989 and 1994. Int Dent J 1999;49:73-5.
54. Beiruti N, Taifour D, van Palenstein Helderman WH, Frencken JE. A review of oral health status in Syria. Int Dent J 2001;51:7-10. (Pubitemid 33721357)
55. Ettinger RL. Epidemiology of dental caries. A broad review. Dent Clin North Am 1999;43:679-94.
56. Do LG. Distribution of caries in children: Variations between and within popluations. J Dent Res 2012;91:536-43.
57. Costa SM, Martins CC, Bonfim Mde L, Zina LG, Paiva SM, Pordeus IA, Abreu MH. A systematic review of socioeconomic indicators and dental caries in adults. Int J Environ Res Public Health 2012;9:3540-74.
58. Brown LJ, Wall TP, Lazar V. Trends in total caries experience: permanent and primary teeth. J Am Dent Assoc 2000; 131:223-31.
59. Edelstein BL, Douglass CW. Dispelling the myth that 50 percent of U.S. schoolchildren have never had a cavity. Public Health Rep 1995; 110: 522-30.
60. USDHSS (United States Department of Health and Human Services). Oral Health of America: A Report of the Surgeon General. National Institutes of Health, 2000.
61. Pitts NB, Boyles J, Nugent ZJ, Thomas N, Pine CM. The dental caries experience of 5-year-old children in England and Wales. Surveys coordinated by the British Association for the Study of Community Dentistry in 2001/2002. Community Dent Health 2003;20:45-54. (Pubitemid 37222564)
62. Campus G, Solinas G, Cagetti MG, Senna A, Minelli L, Majori S, Montagna MT, Reali D, Castiglia P, Strohmenger L. National Pathfinder survey of 12-year-old children's oral health in Italy. Caries Res 2007;41 : 512-7.
63. Slade GD, Spencer AJ, Roberts-Thomson KF. Australia's dental generations. The national survey of adult oral health 2004-2006. AIHW cat no DEN 165, Canberra: Australian Institute of Health and Welfare Dental Statistics and Research Series 34, 2007.
64. Martin-Iverson N, Pacza T, Phatouros A, Tennant M. Indigenous Australian dental health: a brief review of caries experience. Aust Dent J2000:45:17-20.
65. Wang HY, Petersen PE, Bian JY, Zhang BX. The second national survey of oral health status of children and adults in China. Int Dent J 2002;52:283-90.
66. Kaste LM, Selwitz RH, Oldakowski RJ, Brunelle JA, Winn DM, Brown LJ. Coronal caries in the primary and permanent dentition of children and adolescents 1-17 years of age: United States, 1988-1991. J Dent Res 1996;75 (Spec No):631-41. (Pubitemid 32774116)
67. Guzmán-Armstrong S. Rampant caries. J Sch Nurs 2005;21:272-8.
68. Donly KJ, Brown DJ. Identify, protect, restore: emerging issues in approaching children's oral health. Gen Dent 2005;53:106-10. (Pubitemid 40577045)
69. Burgess JO, Gallo JR. Treating root surface caries. Dent Clin North Am 2002;46:385-404.
70. Felber G. Delta Dental Data Analysis Center.
71. Burt BA. Concepts of risk in dental public health. Community Dent Oral Epidemiol 2005;33:240-7. (Pubitemid 41638644)
72. Barber LR, Wilkins EM. Evidence-based prevention, management, and monitoring of dental caries. J Dent Hyg 2002;76:270-5.
73. Giannoni M, D'Amario M, Gatto R, Barone A. Some tools for the identification of high caries risk individuals. A review. Minerva Stomatol 2005;54:111-27.
74. Zero D, Fontana M, Lennon AM. Clinical applications and outcomes of using indicators of risk in caries management. J Dent Educ 2001,65:1126-32.
75. Axelsson P, Lindhe J. Effect of controlled oral procedures on caries and periodontal disease in adults. J Clin Periodontal 1978;5:33-51.
76. van der Ouderaa FJG, Cummins D. Delivery systems for supra- and subgingival plaque control. J Dent Res 1989;68(Spec Iss):1617-24.
77. Newman HN. The rationale for chemical adjuncts in plaque control. Int Dent J 1998;48(Suppl 1):298-304.
78. Cummins D. Mechanisms of action of clinically proven anti-plaque agents. In: Clinical and Biological Aspects of Dentifrices. Embery G, Rölla G, eds. Oxford University Press, Oxford, 1992; pp. 205-28.
79. Scheie AA. Dentifrices in the control of dental caries. In: Clinical and Biological Aspects of Dentifrices. Embery G, Rölla G, eds. Oxford University Press, Oxford, 1992; pp.29-40.
80. 21 CFR 355; Anti-caries Drug Products for Over-the-Counter Human Use; 1995.
81. Duckworth RM, Morgan SN, Ingram GS. Oral fluoride reservoirs and their relationship to anti-caries efficacy. In: Clinical and Biological Aspects of Dentifrices. Embery G, Rölla G, eds, Oxford University Press, Oxford, 1992; pp. 91-104.
82. ten Cate JM. Current concepts on the theories of the mechanism of action of fluoride. Acta Odontol Scand 1999;57:325-9.
83. Lynch RJ, Navada R, Walia R. Low levels of fluoride in plaque and saliva and their effects on the demineralisation and remineralisation of enamel: Role of fluoride toothpastes. Int Dent J2004;54(Suppl 1):304-9.
84. Page DJ. A study of the effects of fluoride delivered from solution and dentifrices on enamel demineralization. Caries Res 1991;25:251 -5.
85. Shellis RP, Duckworth RM. Studies on the cariostatic mechanisms of fluoride. Int Dent J 1994;44(Suppl 1):263-73.
86. Gibbs CD, Atherton SE, Huntington E, Lynch RJ, Duckworth RM. Effect of low levels of fluoride on calcium uptake by demineralized human enamel. Arch Oral Biol 1995;40:879-81.
87. Rölla G, Ogaard B, Cruz Rde A. Topical application of fluorides on teeth. New concepts of mechanisms of interaction. J Clin Periodontal 1993;20:105-8. (Pubitemid 23051681)
88. Topping G, Assaf A. Strong evidence that daily use of fluoride toothpaste prevents caries. Evid Based Dent 2005;6:32.
89. Chaves SC, Vieira-da-Silav LM. Anticaries effectiveness of fluoride tooth paste: a meta-analysis. Rev Saude Publica 2002;36:598-606. (Pubitemid 36041069)
90. Twetman S, Axelsson S, Dahlgren H, Holm AK, Käallestäl C, Lagerhöf F, Lingström P, Mejàre I, Nordenram G, Norlund A, Petersson LG, Söder B. Caries-preventive effect of fluoride toothpaste: a systematic review. Acta Odontol Scand 2003;61:347-55. (Pubitemid 38082336)
91. Marinho VC, Higgins JP, Logan S, Sheiham A. Fluoride toothpastes for preventing dental caries in children and adolescents. The Cochrane Database of Systematic Reviews 2005; Issue 3: Cochrane Library.
92. Twetman S. Caries prevention with flouride toothpaste in children: An update. Eur Arch Pediatr Dent 2009;10:162-7.
93. Pessan JP, Toumba KJ, Buzalaf MA. Topical use of fluorides for caries control. Monogr Oral Sci 2011;22:115-32.
94. Dos Santos AP, Nadansky P, de Oliviera BH. A systematic review and meta-analysis of the effects of fluoride toothpastes on the prevention of dental caries in the primary dentition of preschool children. Community Dent Oral Epidemiol 2012, doi: 10.1111/j.1600-0528.2012.00708.
95. Tavss EA, Mellberg JR, Joziak M, Gambogi RJ, Fisher SW Relationship between dentifrice fluoride concentration and clinical caries reduction. Am J Dent 2003;16:369-74. (Pubitemid 41310032)
96. Baysan A, Lynch E, Ellwood R, Davies R, Petersson L, Borsboom P. Reversal of primary root caries using dentifrices containing 5000 and 1100 ppm fluoride. Caries Res 2001;35:41-6. (Pubitemid 33640902)
97. Jensen ME, Kohout F. The effect of a fluoridated dentifrice on root and coronal caries in an older population. J Am Dent Assoc 1988; 117:829-32.
98. National Institute of Health Consensus Development Panel. National Institute of Health Consensus Development Conference statement. Diagnosis and management of dental caries throughout life. March 26-28, 2001. J Am Dent Assoc 2001;132:1153-61.
99. Bader J D, Shugars DA, Bonito AJ. A systematic review of selected caries prevention and management methods. Community Dent Oral Epidemiol 2001;29:399-411. (Pubitemid 33685782)
100. Fisher J, Johnston S, Hewson N, van Dijk W, Reich E, Eisele J L, Bourgeois D. FDI Global Caries Initiative; Implementing a paradigm shift in dental practice and the global policy context. Int Dent J 2012;62:169-74.
101. Frenken JE, Peters MC, Manton DJ Leal SC, Gordan VV, Eden E. Minimal intervention dentistry for managing dental caries-a review: report of a FDI task group. Int Dent J 2012;62:223-43.
102. Cortes DF, Ellwood RF, Ekstrand KR. An in vitro comparison of a combined FOTI/visual examination of occlusal caries with other caries diagnostic methods and the effect of stain on their diagnostic performance. Caries Res 2003;37:8-16. (Pubitemid 37028330)
103. Stookey GK. Quantitative light fluorescence: a technique for early monitoring of the caries process. Dent Clin North Am 2005;49:753-70. (Pubitemid 41248365)
104. Pretty IA. Caries detection and diagnosis: novel techniques. J Dent 2006; 34:727-39. (Pubitemid 44810858)
105. Acevedo AM, Machedo C, Rivera LE, Wolff M, Kleinberg I. The inhibitory effect of an arginine bicarbonate/calcium carbonate Cavistatcontaining dentifrice on the development of dental caries in Venezuelan school children. J Clin Dent 2005;16:63-70. (Pubitemid 41527051)
106. Wijeyeweera RL, Kleinberg I. Arginolytic and ureolytic activities of pure cultures of human oral bacteria and their effects on the pH response of salivary sediment and dental plaque in vitro. Arch Oral Biol 1989;34:43-53.
107. Burne RA, Marquis RE. Alkali production by oral bacteria and protection against dental caries. FEMS Microbiol Lett 2000; 193:1 -6.
108. Burne RA, Zeng L, Ahn SJ, Palmer SR, Liu Y, Lefebure T, Stanhope MJ, Nascimento MM. Progress dissecting the oral microbiome in caries and health. Adv Dent Res 2012;24:77-80.
109. Shu M, Morou-Bermudez E, Suárez-Pérez E, Rivera-Miranda C, Browngardt CM, Chen YY, Magnusson I, Burne RA. The relationship between dental caries status and dental plaque urease activity. Oral Microbiol Immunol 2007;22:61-6. (Pubitemid 46096197)
110. Morou-Bermudez E, Elias-Boneta A, Billings RJ, Burne RA, GarciaRivas V, Brignoni-Nazario V, Suarez-Perez E. Urease activity in dental plaque and saliva of children during a three-year study period and its relationship with other caries risk factors. Arch Oral Biol 2011;56: 1282-9.
111. Nascimento MM, Gordan W, Garvan CW, Browngardt CM, Burne RA. Correlations of oral bacterial arginine and urea catabolism with caries experience. Oral Microbiol Immunol 2009;24:89-95.
112. Gordan W, Garvan CW, Ottenga ME, Schulte R, Harris PA, McEdward D, Magnusson I. Could alkali production be considered an approach for caries control? Caries Res 2010;44:547-54.
113. Nascimento MM, personal communication.
114. Acevedo AM, Montero M, Rojas-Sanchez F, Machedo C, Rivera LE, Wolff M, Kleinberg I. Clinical evaluation of the ability of Cavistat in a mint confection to inhibit the development of dental caries in children. J Clin Dent 2008; 19:1-8.
115. Yin W Hu DY, Fan X, Feng Y, Zhang YP, Cummins D, Mateo LR, Pretty IA, Ellwood RP. A clinical investigation using quantitative lightinduced fluorescence (QLF) of the anticaries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate. J Clin Dent 2013;24(Spec Iss A):A15-22.
116. Yin W, Hu DY, Li X, Fan X, Zhang YP, Pretty IA, Mateo LR, Cummins D, Ellwood RP. The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF). J Dent 2013;41(Suppl 2):22-8.
117. Srisilapanan P, Korwanich N, Yin W, Chuensuwonkul C, Mateo LR, Cummins D, Ellwood RP. Comparison of the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using Quantitative Light-induced Fluorescence. J Dent 2013;41(Suppl 2):29-34.
118. Hu DY, Yin W, Li X, Feng Y, Zhang YP, Cummins D, Mateo LR, Ellwood RP. A clinical investigation of the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride, as sodium monofluorophosphate in a calcium base, on primary root caries. J Clin Dent 2013;24(Spec Iss A):A23-31.
119. Souza MLR, Cury JA, Tenuta LMA, Zhang YP, Mateo LR, Cummins D, Ellwood RP. Comparing the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries. J Dent 2013;41(Suppl 2):35-41.
120. Kraivaphan P, Amomcliat C, Triratara T, Mateo LR, Ellwood R, (rummins D, DeVizio W, Zhang YP. Two-year caries clinical study of the efficacy of novel dentifrices containing 1.5% arginine, an insoluble calcum compound and 1450 ppm fluoride. Accepted for publication in Caries Res.
121. Wolff M, Corby P, Klaczany G, Santarpia P, Lavender S, Gittins E, Vandeven M, Cummins D, Sullivan R. In vivo effects of a new dentifrice containing 1.5% arginine and 1450 ppm fluoride on plaque metabolism. J Clin Dent 2013;24(Spec Iss A):A45-54.
122. Cantore R, Petrou I, Lavender S, Santarpia P, Liu Z, Gittins E, Vandeven M, Cummins D, Sullivan R, Utgikar N. In situ clinical effects of new dentifrices containing 1.5% arginine and fluoride on enamel de- and remineralization and plaque metabolism. J Clin Dent 2013;24(Spec Iss A):A32-44.