Less than 12 nodes in the surgical specimen after total mesorectal excision following neoadjuvant chemoradiation: It means more than you think!

Annals of Surgical Oncology

Volumn 20, Issue 11, 2013, Pages 3398-3406

  De Campos Lobato, Luiz Felipe ^a,b   Stocchi, Luca ^a   De Sousa, João Batista ^b   Buta, Martin ^a   Lavery, Ian C ^a   Fazio, Victor W ^a   Dietz, David W ^a   Kalady, Matthew F ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CAPECITABINE; FLUOROURACIL; FOLINIC ACID;

ADJUVANT CHEMORADIOTHERAPY; ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CONTINUOUS INFUSION; FEMALE; FOLLOW UP; HUMAN; LYMPH NODE DISSECTION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; RECTUM CARCINOMA; RECTUM RESECTION;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMORADIOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; DIGESTIVE SYSTEM SURGICAL PROCEDURES; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; LEUCOVORIN; LYMPH NODE EXCISION; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; PROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 84883796263     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-013-3010-x     Document Type: Article

References (39)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10-29.
2. NCCN Guindelines. 2011. http://www.nccn.org/professionals/physician-gls/ f-guidelines.asp. Accessed 3 Nov 2012.
3. Compton CC, Fielding LP, Burgart LJ, Conley B, Cooper HS, Hamilton SR et al. Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med. 2000;124:979-94.
4. Nelson H, Petrelli N, Carlin A, Couture J, Fleshman J, Guillem J et al. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst. 2001;93:583-96.
5. Edge S, Byrd D, Compton C, Fritz A, Greene F, Trotti I. AJCC - Cancer staging manual, 7 edn. New York: Springer; 2010.
6. Washington MK, Berlin J, Branton P, Burgart LJ, Carter DK, Fitzgibbons PL et al. Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum. Arch Pathol Lab Med. 2009;133:153-51.
7. Anthony T, Simmang C, Hyman N, Buie D, Kim D, Cataldo P et al. Practice parameters for the surveillance and follow-up of patients with colon and rectal cancer. Dis Colon Rectum. 2004;47:807-17.
8. Benson AB 3rd, Schrag D, Somerfield MR, Cohen AM, Figueredo AT, Flynn PJ et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol. 2004;22:3408-19.
9. The Association of Coloproctology of Great Britain and Ireland (2012) The Association of Coloproctology of Great Britain and Ireland (2011). Guidelines for the Management of Colorectal Cancer. http://www.acpgbi.org.uk/members/ guidelines/filter/documents/. Accessed 3 Nov 2012.
10. Wang J, Kulaylat M, Rockette H, Hassett J, Rajput A, Dunn KB, Dayton M. Should total number of lymph nodes be used as a quality of care measure for stage III colon cancer? Ann Surg. 2009;249:559-63.
11. Stocchi L, Fazio VW, Lavery I, Hammel J. Individual surgeon, pathologist, and other factors affecting lymph node harvest in stage II colon carcinoma. Is a minimum of 12 examined lymph nodes sufficient? Ann Surg Oncol. 2011;18:405-12.
12. Vather R, Sammour T, Kahokehr A, Connolly AB, Hill AG. Lymph node evaluation and long-term survival in Stage II and Stage III colon cancer: a national study. Ann Surg Oncol. 2009;16:585-93.
13. Wang H, Safar B, Wexner S, Zhao R, Cruz-Correa M, Berho M. Lymph node harvest after proctectomy for invasive rectal adenocarcinoma following neoadjuvant therapy: does the same standard apply? Dis Colon Rectum. 2009;52:549-57.
14. de la Fuente SG, Manson RJ, Ludwig KA, Mantyh CR. Neoadjuvant chemoradiation for rectal cancer reduces lymph node harvest in proctectomy specimens. J Gastrointest Surg. 2009;13:269-74.
15. de Campos-Lobato LF, Stocchi L, da Luz Moreira A, Geisler D, Dietz DW, Lavery IC et al. Pathologic complete response after neoadjuvant treatment for rectal cancer decreases distant recurrence and could eradicate local recurrence. Ann Surg Oncol. 2011;18:1590-8.
16. de Campos-Lobato LF, Geisler DP, da Luz Moreira A, Stocchi L, Dietz D, Kalady MF. Neoadjuvant therapy for rectal cancer: the impact of longer interval between chemoradiation and surgery. J Gastrointest Surg. 2011;15:444-50.
17. de Campos-Lobato LF, Wells B, Wick E, Pronty K, Kiran R, Remzi F, Vogel JD. Predicting organ space surgical site infection with a nomogram. J Gastrointest Surg. 2009;13:1986-92.
18. Lavery IC, Lopez-Kostner F, Fazio VW, Fernandez-Martin M, Milsom JW, Church JM. Chances of cure are not compromised with sphincter-saving procedures for cancer of the lower third of the rectum. Surgery. 1997;122:779-84; discussion 784-5.
19. Lopez-Kostner F, Lavery IC, Hool GR, Rybicki LA, Fazio VW. Total mesorectal excision is not necessary for cancers of the upper rectum. Surgery. 1998;124:612-7; discussion 617-8.
20. Lavery IC, Lopez-Kostner F, Pelley RJ, Fine RM. Treatment of colon and rectal cancer. Surg Clin North Am. 2000;80:535-69.
21. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery-the clue to pelvic recurrence? Br J Surg. 1982;69:613-6.
22. de Campos-Lobato LF, Stocchi L, Dietz DW, Lavery IC, Fazio VW, Kalady MF. Prone or lithotomy positioning during an abdominoperineal resection for rectal cancer results in comparable oncologic outcomes. Dis Colon Rectum. 2011;54:939-46.
23. Compton CC. Updated protocol for the examination of specimens from patients with carcinomas of the colon and rectum, excluding carcinoid tumors, lymphomas, sarcomas, and tumors of the vermiform appendix: a basis for checklists. Cancer Committee. Arch Pathol Lab Med. 2000;124:1016-25.
24. Sobin LH, Fleming ID. TNM classification of malignant tumors. Fifth edition. Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer. 1997. pp.1803-4.
25. Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, Morrow M. AJCC cancer staging manual, 6 edn. Chicago: Springer; 2002.
26. American Society of Colon & Rectal Surgeons. Screening & Surveillance for Colorectal Cancer. 2008. http://www.fascrs.org/patients/ treatments-and-screenings/assess-your-risk-for-colorectal-cancer/screening/. Accessed 3 Nov 2012.
27. Wirtzfeld DA, Mikula L, Gryfe R, Ravani P, Dicks El, Parfrey P et al. Concordance with clinical practice guidelines for adjuvant chemotherapy in patients with stage I-III colon cancer: experience in 2 Canadian provinces. Can J Surg. 2009;52:92-7.
28. Pocock SJ, Clayton TC, Altman DG. Survival plots of time-to-event outcomes in clinical trials: good practice and pitfalls. Lancet. 2002;359:1686-9.
29. Marks JH, Valsdottir EB, Rather AA, Nweze IC, Newman DA, Chernick MR. Fewer than 12 lymph nodes can be expected in a surgical specimen after high-dose chemoradiation therapy for rectal cancer. Dis Colon Rectum. 2010;53:1023-9.
30. Govindarajan A, Gonen M, Weiser MR, Shia J, Temple LK, Guillem JG et al. Challenging the feasibility and clinical significance of current guidelines on lymph node examination in rectal cancer in the era of neoadjuvant therapy. J Clin Oncol. 2011;29:4568-73.
31. Habr-Gama A, Perez RO, Proscurshim I, Nunes Dos Santos RM, Kiss D, Gama-Rodrigues J, Cecconello I. Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: does delayed surgery have an impact on outcome? Int J Radiat Oncol Biol Phys. 2008;71:1181-8.
32. Rullier A, Laurent C, Capdepont M, Vendrely V, Belleannee G, Bioulac-Sage P, Rullier E. Lymph nodes after preoperative chemoradiotherapy for rectal carcinoma: number, status, and impact on survival. Am J Surg Pathol. 2008;32:45-50.
33. de Campos-Lobato LF, Stocchi L, da Luz Moreira A, Kalady MF, Geisler D, Dietz D et al. Downstaging without complete pathologic response after neoadjuvant treatment improves cancer outcomes for cIII but not cII rectal cancers. Ann Surg Oncol. 2010;17:1758-66.
34. Fajardo LF. Effects of ionizing radiation on lymph nodes. A review. Front Radiat Ther Oncol. 1994;28:37-45.
35. Shvero J, Koren R, Marshak G, Sadov R, Hadar T, Yaniv E et al. Histological changes in the cervical lymph nodes after radiotherapy. Oncol Rep. 2001;8:909-11.
36. Stipa F, Zernecke A, Moore HG, Minsky BD, Wong WD, Weiser M et al. Residual mesorectal lymph node involvement following neoadjuvant combined-modality therapy: rationale for radical resection? Ann Surg Oncol. 2004;11:187-91.
37. Zmora O, Dasilva GM, Gurland B, Pfeffer R, Koller M, Nogueras JJ, Wexner SD. Does rectal wall tumor eradication with preoperative chemoradiation permit a change in the operative strategy? Dis Colon Rectum. 2004;47:1607-12.
38. Mignanelli ED, de Campos-Lobato LF, Stocchi L, Lavery IC, Dietz DW. Downstaging after chemoradiotherapy for locally advanced rectal cancer: is there more (tumor) than meets the eye? Dis Colon Rectum. 2010;53:251-6.
39. National Cancer Institute - Surveillence Epidemiology and End Results. SEER Cancer Statistics Review. 2009. http://seer.cancer.gov/csr/1975-2006/. Accessed 3 Nov 2012.