Fewer than 12 lymph nodes can be expected in a surgical specimen after high-dose chemoradiation therapy for rectal cancer

Diseases of the Colon and Rectum

Volumn 53, Issue 7, 2010, Pages 1023-1029

  Marks, J H ^a   Valsdottir, E B ^a   Rather, A A ^a   Nweze, I C ^a   Newman, D A ^a   Chernick, M R ^a  

^a LANKENAU HOSPITAL   (United States)

Author keywords

Lymph nodes; Neoadjuvant chemoradiation; Rectal adenocarcinoma; Total mesorectal excision

Indexed keywords

FLUOROURACIL;

ADJUVANT CHEMOTHERAPY; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DATA BASE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; RADIATION DOSE; RECTUM CANCER; RISK FACTOR; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; COLECTOMY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; PELVIS; PROSPECTIVE STUDIES; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77954395839     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/DCR.0b013e3181dadeb4     Document Type: Article

References (28)

1. Baxter NN, Virnig DJ, Rothenberger DA, Morris AM, Jessurun J, Virnig BA. Lymph node evaluation in colorectal cancer patient: a population-based study. J Natl Cancer Inst. 2005;97:219-225.
2. Caplin S, Cerottini JP, Bosman FT, Constanda MT, Givel JC. For patients with Dukes' B (TNM stage II) colorectal carcinoma, examination of six or fewer lymph nodes is related to poor prognosis. Cancer. 1998;83:666-672.
3. Berger AC, Sigurdson ER, LeVoyer T, et al. Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes. J Clin Oncol. 2005;23:8706-8712.
4. Lee HY, Choi HJ, Park KJ, et al. Prognostic significance of metastatic lymph node ratio in node-positive colon carcinoma. Ann Surg Oncol. 2007;14:1712-1717.
5. Johnson PM, Porter GA, Ricciardi R, Baxter NN. Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer. J Clin Oncol. 2006;24:3570-3575.
6. Greene FL, Page DL, Fleming ID, et al, eds. AJCC Cancer Staging Manual. American Joint Committee. 6th ed. New York, NY: Springer; 2006.
7. Sobin LH, Wittekind Ch, eds. TNM Classification of Malignant Tumors. 5th ed. New York, NY: Wiley; 1997:64-67.
8. Nelson H, Petrelli N, Carlin A, et al. Guidelines 2000 for Colon and Rectal Cancer Surgery. J Natl Cancer Inst. 2001;93:583-596.
9. National Quality Forum Endorsed Commission on Cancer Measures for Quality of Cancer Care for Breast and Colorectal Cancers. ACS Press Release, May 14, 2007. www.facs.org/ cancer/qualitymeasures.html. First accessed March 9, 2008.
10. Marks G, Mohiuddin M, Borenstein BD. Preoperative radiation therapy and sphincter preservation by the combined abdominotranssacral technique for selected rectal cancers. Dis Colon Rectum. 1985;28:565-571.
11. Anonymous. Swedish Rectal Cancer Trial: Improved survival with preoperative radiotherapy in resectable rectal cancer. New Engl J Med. 1997;336:980-987.
12. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiation for rectal cancer. N Engl J Med. 2004;351:1731-1740.
13. Anonymous. Colorectal Cancer Collaborative Group. Adjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patients from 22 randomized trials. Lancet. 2001;358:1291-1304.
14. Marks GJ, Marks JH, Mohiuddin M, Brady L. Radical sphincter preservation surgery with coloanal anastomosis following highdose external irradiation for the very low lying rectal cancer. Recent Results Cancer Res. 1998;146:161-174.
15. Hernanz F, Revuelta S, Redondo C, et al. Colorectal adenocarcinoma: quality of the assessment of lymph node metastasis. Dis Colon Rectum. 1994;37:373-377.
16. Fielding LP, Arsenault PA, Chapuis PH, et al. Clinicopathological staging for colorectal cancer: an international documentation system (IDS) and an international comprehensive anatomical terminology (ICAT). J Gastroenterol Hepatol. 1991;6:325-344.
17. Maurel J, Launoy G, Grosclaude P, et al. Lymph node harvest reporting in patient with carcinoma of the large bowel. Cancer. 1998;82:1482-1486.
18. Leibl S, Tsybrovskyy O, Denk H. How many lymph nodes are necessary to stage early and advanced adenocarcinoma of the sigmoid colon and upper rectum? Virchows Archiv. 2003;443: 133-138.
19. Cianchi F, Palomba A, Boddi V, et al. Lymph node recovery from colorectal tumor specimens: recommendations for a minimum number of lymph nodes to be examined. World J Surg. 2002;26:384-389.
20. Beresford M, Glynne-Jones R, Rickman P, et al. The reliability of lymph-node staging in rectal cancer after preoperative chemoradiotherapy. Clin Oncol (R Coll Radiol). 2005;17:448-455.
21. Habr-Gama A, Perez RO, Proscurshim I, et al. Absence of lymph nodes in the resected specimen after radical surgery for distal rectal cancer and neoadjuvant chemoradiation therapy: what does it mean? Dis Colon Rectum. 2008;51:277-283.
22. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery: the clue to pelvic recurrence? Br J Surg. 1982;69: 613-616.
23. Kapiteijn E, Marijnen C, Nagtegaal I, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345:638-646.
24. Hyams DM, Mamounas EP, Petrelli N, et al. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum. Dis Colon Rectum. 1997;40:131-139.
25. Lim CS, Mehigan BJ, Hartley JE, Monson JR. Neoadjuvant therapy in the treatment of high risk rectal carcinoma. Surg Oncol. 1999;8:1-11.
26. Mohiuddin M, Regine W, Marks G, Marks J. High-dose preoperative radiation and the challenge of sphincter preservation surgery for cancer of the distal 2 cm of the rectum. Int J Radiat Oncol Biol Phys. 1998;40:569-574.
27. Scott KWM, Grace RH. Detection of lymph node metastasis in colorectal carcinoma before and after fat clearance. Br J Surg. 1989;76:1165-1167.
28. Jass JR, Miller K, Northover JMA. Fat clearance method versus manual dissection of lymph nodes in specimens of rectal cancer. Int J Colorect Dis. 1986;1:155-156.