Separacenes A-D, novel polyene polyols from the marine actinomycete, streptomyces sp

Marine Drugs

Volumn 11, Issue 8, 2013, Pages 2882-2893

  Bae, Munhyung ^a   Kim, Heegyu ^b   Shin, Yoonho ^a   Kim, Byung Yong ^c   Lee, Sang Kook ^a   Oh, Ki Bong ^b   Shin, Jongheon ^a   Oh, Dong Chan ^a  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c National Institute of Animal Science   (South Korea)

Author keywords

Cytotoxicity; Isocitrate lyase; Marine actinomycete; Polyene polyol

Indexed keywords

3 NITROPROPIONIC ACID; AMPHOTERICIN B; AMPICILLIN; ISOCITRATE LYASE; POLYOL; SEPARACENE A; SEPARACENE B; SEPARACENE C; SEPARACENE D; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANDIDA ALBICANS; COLON CARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; LUNG CANCER; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STREPTOMYCES; ULTRAVIOLET SPECTROSCOPY;

CANDIDA ALBICANS; STREPTOMYCES; STREPTOMYCES SP.;

ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; CANDIDA ALBICANS; CELL LINE, TUMOR; COLONIC NEOPLASMS; HCT116 CELLS; HUMANS; LUNG NEOPLASMS; POLYENES; POLYMERS; REPUBLIC OF KOREA; SPECTRUM ANALYSIS; STREPTOMYCES;

EID: 84883787583     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md11082882     Document Type: Article

References (13)

1. Li, J.W.-H.; Vederas, J.C. Drug discovery and natural products: End of an era or an endless frontier. Science 2009, 325, 161-165.
2. Weissman, K.J.; Leadlay, P.F. Combinatorial biosynthesis of reduced polyketides. Nat. Rev. Microbiol. 2005, 3, 925-936.
3. Clardy, J.; Walsh, C. Lessons from natural molecules. Nature 2004, 432, 829-837.
4. Bérdy, J. Bioactive microbial metabolites. J. Antibiot. 2005, 58, 1-26.
5. Fenical, W.; Jensen, P.R. Developing a new resource for drug discovery: Marine actinomycete bacteria. Nat. Chem. Biol. 2006, 2, 666-673.
6. Molinski, T.F.; Dalisay, D.S.; Lievens, S.L.; Saludes, J.P. Drug development from marine natural products. Nat. Drug. Discov. 2009, 8, 69-85.
7. Fenical, W.; Jensen, P.R.; Palladino, M.A.; Lam, K.S.; Lloyd, G.K.; Potts, B.C. Discovery and development of the anticancer agent salinosporamide A(NPI-0052). Bioorg. Med. Chem. 2009, 17, 2175-2180.
8. Singh, R.; Sharma, M.; Joshi, P.; Rawat, D.S. Clinical status of anti-cancer agents derived from marine sources. Anti-Cancer Agents Med. Chem. 2008, 8, 603-617.
9. Kim, D.-G.; Moon, K.; Kim, S.-H.; Park, S.-H.; Park, S.; Lee, S.K.; Oh, K.-B.; Shin, J.; Oh, D.-C. Bahamaolides A and B, antifungal polyene polyol macrolides from the marine actinomycete, Streptomyces sp. J. Nat. Prod. 2012, 75, 959-967.
10. Um, S.; Kim, Y.-J.; Kwon, H.; Wen, H.; Kim, S.-H.; Kwon, H.C.; Park, S.; Shin, J.; Oh, D.-C. Sungsanpin, a lasso peptide from a deep-sea streptomycete. J. Nat. Prod. 2013, 76, 873-879.
11. Félix, F.; Seco, J.M.; Quiñoá, E.; Riguera, R. Determining the absolute stereochemistry of secondary/secondary diols by 1H NMR: Basis and applications. J. Org. Chem. 2005, 70, 3778-3790.
12. Jiang, Z.D. Isolation of Antifungal Agents from Pine Roots. WO 9800091 A2, 8 January 1998.
13. Dunn, M.F.; Ramirez-Trujillo, J.A.; Hernandez-Lucas, I. Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis. Microbiology 2009, 155, 3166-3175.