RUNX1, but not its familial platelet disorder mutants, synergistically activates PF4 gene expression in combination with ETS family proteins

Journal of Thrombosis and Haemostasis

Volumn 11, Issue 9, 2013, Pages 1742-1750

  Okada, Y ^a   Watanabe, M ^a   Nakai, T ^a   Kamikawa, Y ^a   Shimizu, M ^a   Fukuhara, Y ^a   Yonekura, M ^a   Matsuura, E ^a   Hoshika, Y ^a   Nagai, R ^a   Aird, W C ^b   Doi, T ^a  

^a OSAKA UNIVERSITY   (Japan)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

ETS1 protein, human; FLI1 protein, human; Megakaryocytes; Platelet disorder, familial, with associated myeloid malignancy; Platelet factor 4; RUNX1 protein, human

Indexed keywords

CORE BINDING FACTOR BETA; THROMBOCYTE FACTOR 4; TRANSCRIPTION FACTOR RUNX1;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DNA BINDING; EMBRYONIC STEM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; REPORTER GENE; THROMBOCYTE DISORDER; THROMBOCYTE FUNCTION; TRANSCRIPTION INITIATION; UPREGULATION;

ETS1 PROTEIN, HUMAN; FLI1 PROTEIN, HUMAN; MEGAKARYOCYTES; PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY; PLATELET FACTOR 4; RUNX1 PROTEIN, HUMAN;

BLOOD PLATELET DISORDERS; CELL LINE; CORE BINDING FACTOR ALPHA 2 SUBUNIT; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HUMANS; MUTATION; PLATELET FACTOR 4; PROTO-ONCOGENE PROTEINS C-ETS; REAL-TIME POLYMERASE CHAIN REACTION; SUBCELLULAR FRACTIONS;

EID: 84883780848     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12355     Document Type: Article

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