Cryptochrome restores dampened circadian rhythms and promotes healthspan in aging Drosophila

Aging Cell

Volumn 12, Issue 5, 2013, Pages 752-762

  Rakshit, Kuntol ^a   Giebultowicz, Jadwiga M ^a  

^a OREGON STATE UNIVERSITY   (United States)

Author keywords

Aging; Circadian clock; Cryptochrome; Drosophila; Healthspan

Indexed keywords

CRYPTOCHROME; MESSENGER RNA; TRANSCRIPTION FACTOR GAL4;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CIRCADIAN RHYTHM; CONTROLLED STUDY; DARKNESS; DROSOPHILA MELANOGASTER; GENE OVEREXPRESSION; LIFESPAN; LOCOMOTION; MALE; MUTANT; NERVE CELL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; REST;

ANIMALIA; DROSOPHILA MELANOGASTER;

AGING; CIRCADIAN CLOCK; CRYPTOCHROME; DROSOPHILA; HEALTHSPAN;

AGE FACTORS; ANIMALS; BEHAVIOR, ANIMAL; CIRCADIAN RHYTHM; CRYPTOCHROMES; DROSOPHILA; MALE; RNA, MESSENGER;

EID: 84883779950     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12100     Document Type: Article

References (45)

1. Antoch MP, Gorbacheva VY, Vykhovanets O, Toshkov IA, Kondratov RV, Kondratova AA, Lee C, Nikitin AY (2008) Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle 7, 1197-1204.
2. Bae K, Lee C, Hardin PE, Edery I (2000) dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER- TIM complex. J. Neurosci. 20, 1746-1753.
3. Busza A, Emery-Le M, Rosbash M, Emery P (2004) Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science 304, 1503-1506.
4. Collins B, Mazzoni EO, Stanewsky R, Blau J (2006) Drosophila CRYPTOCHROME is a circadian transcriptional repressor. Curr. Biol. 16, 441-449.
5. Cyran SA, Buchsbaum AM, Reddy KL, Lin MC, Glossop NR, Hardin PE, Young MW, Storti RV, Blau J (2003) vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell 112, 329-341.
6. Davidson AJ, Sellix MT, Daniel J, Yamazaki S, Menaker M, Block GD (2006) Chronic jet-lag increases mortality in aged mice. Curr. Biol. 16, R914-R916.
7. Dolezelova E, Dolezel D, Hall JC (2007) Rhythm defects caused by newly engineered null mutations in Drosophila's cryptochrome gene. Genetics 177, 329-345.
8. Emery P, So V, Kaneko M, Hall JC, Rosbash M (1998) CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell 95, 669-679.
9. Emery P, Stanewsky R, Helfrich-Foster C, Emery-Le M, Hall JC, Rosbash M (2000) Drosophila CRY is a deep brain circadian photoreceptor. Neuron 26, 493-504.
10. Fogle KJ, Parson KG, Dahm NA, Holmes TC (2011) CRYPTOCHROME is a blue-light sensor that regulates neuronal firing rate. Science 331, 1409-1413.
11. Hardin PE (2011) Molecular genetic analysis of circadian timekeeping in Drosophila. Adv. Genet. 74, 141-173.
12. Hofman MA, Swaab DF (2006) Living by the clock: the circadian pacemaker in older people. Ageing Res. Rev. 5, 33-51.
13. Huang YL, Liu RY, Wang QS, Van Someren EJ, Xu H, Zhou JN (2002) Age-associated difference in circadian sleep-wake and rest-activity rhythms. Physiol. Behav. 76, 597-603.
14. Ivanchenko M, Stanewsky R, Giebultowicz JM (2001) Circadian photoreception in Drosophila: functions of cryptochrome in peripheral and central clocks. J. Biol. Rhythms 16, 205-215.
15. Kaneko M, Hall JC (2000) Neuroanatomy of cells expressing clock genes in Drosophila: transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J. Comp. Neurol. 422, 66-94.
16. Klarsfeld A, Malpel S, Michard-Vanhee C, Picot M, Chelot E, Rouyer F (2004) Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J. Neurosci. 24, 1468-1477.
17. Koh K, Evans JM, Hendricks JC, Sehgal A (2006) A Drosophila model for age-associated changes in sleep: wake cycles. Proc. Natl Acad. Sci. USA 103, 13843-13847.
18. Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV, Antoch MP (2006) Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock. Genes Dev. 20, 1868-1873.
19. Kondratova AA, Kondratov RV (2012) The circadian clock and pathology of the ageing brain. Nat. Rev. Neurosci. 13, 325-335.
20. Krishnan B, Levine JD, Lynch MK, Dowse HB, Funes P, Hall JC, Hardin PE, Dryer SE (2001) A new role for cryptochrome in a Drosophila circadian oscillator. Nature 411, 313-317.
21. Krishnan N, Davis AJ, Giebultowicz JM (2008) Circadian regulation of response to oxidative stress in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 374, 299-303.
22. Krishnan N, Kretzschmar D, Rakshit K, Chow E, Giebultowicz J (2009) The circadian clock gene period extends healthspan in aging Drosophila melanogaster. Aging (Albany NY) 1, 937-948.
23. Krishnan N, Rakshit K, Chow ES, Wentzell JS, Kretzschmar D, Giebultowicz JM (2012) Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. Neurobiol. Dis. 45, 1129-1135.
24. Kumar S, Chen D, Sehgal A (2012) Dopamine acts through Cryptochrome to promote acute arousal in Drosophila. Genes Dev. 26, 1224-1234.
25. Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98, 193-205.
26. Luo W, Chen WF, Yue Z, Chen D, Sowcik M, Sehgal A, Zheng X (2012) Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations. Aging Cell 11, 428-438.
27. Martin I, Gargano JW, Grotewiel M (2005) A proposed set of descriptors for functional senescence data. Aging Cell 4, 161-164.
28. Nakamura TJ, Nakamura W, Yamazaki S, Kudo T, Cutler T, Colwell CS, Block GD (2012) Age-related decline in circadian output. J. Neurosci. 31, 10201-10205.
29. Nitabach MN, Taghert PH (2008) Organization of the Drosophila circadian control circuit. Curr. Biol. 18, R84-R93.
30. Oster H, Baeriswyl S, Van Der Horst GT, Albrecht U (2003) Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice. Genes Dev. 17, 1366-1379.
31. Park JH, Helfrich-Forster C, Lee G, Liu L, Rosbash M, Hall JC (2000) Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc. Natl Acad. Sci. USA 97, 3608-3613.
32. Rakshit K, Krishnan N, Guzik EM, Pyza E, Giebultowicz JM (2012) Effects of aging on the molecular circadian oscillations in Drosophila. Chronobiol. Int. 29, 1-10.
33. Reddy AB, O'Neill JS (2010) Healthy clocks, healthy body, healthy mind. Trends Cell Biol. 20, 36-44.
34. Rhodenizer D, Martin I, Bhandari P, Pletcher SD, Grotewiel M (2008) Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed. Exp. Gerontol. 43, 739-748.
35. Rush BL, Murad A, Emery P, Giebultowicz JM (2006) Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary. J. Biol. Rhythms 21, 272-278.
36. Seay DJ, Thummel CS (2011) The circadian clock, light, and cryptochrome regulate feeding and metabolism in Drosophila. J. Biol. Rhythms 26, 497-506.
37. Stanewsky R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54, 111-147.
38. b mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell 95, 681-692.
39. Umezaki Y, Yoshii T, Kawaguchi T, Helfrich-Forster C, Tomioka K (2012) Pigment-Dispersing Factor Is Involved in Age-Dependent Rhythm Changes in Drosophila melanogaster. J. Biol. Rhythms 27, 423-432.
40. Valentinuzzi VS, Scarbrough K, Takahashi JS, Turek FW (1997) Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. Am. J. Physiol. 273, R1957-R1964.
41. Vieira J, Jones AR, Danon A, Sakuma M, Hoang N, Robles D, Tait S, Heyes DJ, Picot M, Yoshii T, Helfrich-Forster C, Soubigou G, Coppee JY, Klarsfeld A, Rouyer F, Scrutton NS, Ahmad M (2012) Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability. PLoS ONE 7, e31867.
42. Wijnen H, Young MW (2006) Interplay of circadian clocks and metabolic rhythms. Annu. Rev. Genet. 40, 409-448.
43. Xu K, DiAngelo JR, Hughes ME, Hogenesch JB, Sehgal A (2011) The circadian clock interacts with metabolic physiology to influence reproductive fitness. Cell Metab. 13, 639-654.
44. Yu W, Hardin PE (2006) Circadian oscillators of Drosophila and mammals. J. Cell Sci. 119, 4793-4795.
45. Yu EA, Weaver DR (2011) Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging (Albany NY). 3, 479-493.