메뉴 건너뛰기




Volumn 347, Issue 7923, 2013, Pages

Do risks outweigh benefits in thrombolysis for stroke?

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; PLACEBO;

EID: 84883769537     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.f5215     Document Type: Article
Times cited : (19)

References (36)
  • 1
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581-7.
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 3
    • 0033485522 scopus 로고    scopus 로고
    • Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: A randomized controlled trial
    • Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. JAMA 1999;282:2019-26.
    • (1999) JAMA , vol.282 , pp. 2019-2026
    • Clark, W.M.1    Wissman, S.2    Albers, G.W.3    Jhamandas, J.H.4    Madden, K.P.5    Hamilton, S.6
  • 4
    • 0034120507 scopus 로고    scopus 로고
    • The rtPA (Alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): Results of a double-blind, placebo-controlled, multicenter study
    • Clark WM, Albers GW, Madden KP, Hamilton S. The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter study. Stroke 2000;31:811-6. (Pubitemid 30198420)
    • (2000) Stroke , vol.31 , Issue.4 , pp. 811-816
    • Clark, W.M.1    Albers, G.W.2    Madden, K.P.3    Hamilton, S.4
  • 5
    • 84862629039 scopus 로고    scopus 로고
    • Recombinant tissue plasminogen activator for acute ischaemic stroke: An updated systematic review and meta-analysis
    • Wardlaw JM, Murray V, Berge E, Del Zoppo G, Sandercock P, Lindley RL, Cohen G. Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis. Lancet 2012;379:2364-72.
    • (2012) Lancet , vol.379 , pp. 2364-2372
    • Wardlaw, J.M.1    Murray, V.2    Berge, E.3    Del Zoppo, G.4    Sandercock, P.5    Lindley, R.L.6    Cohen, G.7
  • 6
    • 84858149658 scopus 로고    scopus 로고
    • Skepticism about thrombolytics in stroke is not unreasonable
    • Radecki RP. Skepticism about thrombolytics in stroke is not unreasonable. Nat Rev Neurol 2012;8:176.
    • (2012) Nat Rev Neurol , vol.8 , pp. 176
    • Radecki, R.P.1
  • 7
    • 84867320623 scopus 로고    scopus 로고
    • How is more negative evidence being used to support claims of benefit: The curious case of the third international stroke trial (IST-3)
    • Hoffman JR, Cooper RJ. How is more negative evidence being used to support claims of benefit: The curious case of the third international stroke trial (IST-3). Emerg Med Australas 2012;24:473-6.
    • (2012) Emerg Med Australas , vol.24 , pp. 473-476
    • Hoffman, J.R.1    Cooper, R.J.2
  • 8
    • 84867298405 scopus 로고    scopus 로고
    • Believing is seeing: Stroke thrombolysis remains unproven after the third international stroke trial (IST-3)
    • Fatovich DM. Believing is seeing: Stroke thrombolysis remains unproven after the third international stroke trial (IST-3). Emerg Med Australas 2012;24:477-9.
    • (2012) Emerg Med Australas , vol.24 , pp. 477-479
    • Fatovich, D.M.1
  • 9
    • 4944222683 scopus 로고    scopus 로고
    • Findings from the reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trial
    • DOI 10.1161/01.STR.0000140891.70547.56
    • Ingall TJ, O'Fallon WM, Asplund K, Goldfrank LR, Hertzberg VS, Louis TA, et al. Findings from the reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trial. Stroke 2004;35:2418-24. (Pubitemid 39328073)
    • (2004) Stroke , vol.35 , Issue.10 , pp. 2418-2424
    • Ingall, T.J.1    O'Fallon, W.M.2    Asplund, K.3    Goldfrank, L.R.4    Hertzberg, V.S.5    Louis, T.A.6    Hengy Christianson, T.J.7
  • 10
    • 68649084182 scopus 로고    scopus 로고
    • A graphic reanalysis of the NINDS Trial
    • 336.e1-35
    • Hoffman JR, Schriger DL. A graphic reanalysis of the NINDS Trial. Ann Emerg Med 2009;54:329-36, 336.e1-35.
    • (2009) Ann Emerg Med , vol.54 , pp. 329-336
    • Hoffman, J.R.1    Schriger, D.L.2
  • 11
    • 77958009866 scopus 로고    scopus 로고
    • Graphic reanalysis of the two NINDS-tPA trials confirms substantial treatment benefit
    • Saver JL, Gornbein J, Starkman S. Graphic reanalysis of the two NINDS-tPA trials confirms substantial treatment benefit. Stroke 2010;41:2381-90.
    • (2010) Stroke , vol.41 , pp. 2381-2390
    • Saver, J.L.1    Gornbein, J.2    Starkman, S.3
  • 12
    • 84894647895 scopus 로고    scopus 로고
    • Implications of ECASS III error on emergency department treatment of ischemic stroke
    • Nov 7 [Epub ahead of print]
    • Shy BD. Implications of ECASS III error on emergency department treatment of ischemic stroke. J Emerg Med 2012 Nov 7 [Epub ahead of print].
    • (2012) J Emerg Med
    • Shy, B.D.1
  • 13
    • 77949879131 scopus 로고    scopus 로고
    • Towards evidence based emergency medicine: Best BETs from the Manchester Royal Infirmary. BET 3: Use of thrombolysis in acute ischaemic stroke
    • Ferguson C. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 3: use of thrombolysis in acute ischaemic stroke. Emerg Med J 2010;27:245-8.
    • (2010) Emerg Med J , vol.27 , pp. 245-248
    • Ferguson, C.1
  • 14
    • 84862625338 scopus 로고    scopus 로고
    • The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): A randomised controlled trial
    • IST-3 Collaborative Group
    • IST-3 Collaborative Group. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet 2012;379:2352-63.
    • (2012) Lancet , vol.379 , pp. 2352-2363
  • 15
    • 84861585407 scopus 로고    scopus 로고
    • In anticipation of International Stroke Trial-3 (IST-3)
    • Lyden PD. In anticipation of International Stroke Trial-3 (IST-3). Stroke 2012;43:1691-4.
    • (2012) Stroke , vol.43 , pp. 1691-1694
    • Lyden, P.D.1
  • 16
    • 84876570671 scopus 로고    scopus 로고
    • Rt-PA and stroke: Does IST-3 make it all clear or muddy the waters? Answers to the November 2012 journal club questions
    • Radecki RP, Chathampally YG, Press GM. rt-PA and stroke: does IST-3 make it all clear or muddy the waters? Answers to the November 2012 journal club questions. Ann Emerg Med 2013;61:489-98.
    • (2013) Ann Emerg Med , vol.61 , pp. 489-498
    • Radecki, R.P.1    Chathampally, Y.G.2    Press, G.M.3
  • 17
    • 84880326684 scopus 로고    scopus 로고
    • Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial
    • IST-3 Collaborative Group
    • IST-3 Collaborative Group. Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial. Lancet Neurol 2013;8:768-76.
    • (2013) Lancet Neurol , vol.8 , pp. 768-776
  • 18
    • 0037108235 scopus 로고    scopus 로고
    • Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: Current practice and problems
    • Pocock SJ, Assmann SE, Enos LE, Kasten LE. Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems. Stat Med 2002;21:2917-30.
    • (2002) Stat Med , vol.21 , pp. 2917-2930
    • Pocock, S.J.1    Assmann, S.E.2    Enos, L.E.3    Kasten, L.E.4
  • 19
    • 70349686724 scopus 로고    scopus 로고
    • Reliability of the modified Rankin scale: A systematic review
    • Quinn TJ, Dawson J, Walters MR, Lees KR. Reliability of the modified Rankin scale: a systematic review. Stroke 2009;40:3393-5.
    • (2009) Stroke , vol.40 , pp. 3393-3395
    • Quinn, T.J.1    Dawson, J.2    Walters, M.R.3    Lees, K.R.4
  • 20
    • 0035798948 scopus 로고    scopus 로고
    • Reliable assessment of the effects of treatment on mortality and major morbidity, I: Clinical trials
    • DOI 10.1016/S0140-6736(00)03651-5
    • Collins R, MacMahon S. Reliable assessment of the effects of treatment on mortality and major morbidity. 1. Clinical trials. Lancet 2001;357:373-80. (Pubitemid 32128549)
    • (2001) Lancet , vol.357 , Issue.9253 , pp. 373-380
    • Collins, R.1    MacMahon, S.2
  • 22
    • 77955665657 scopus 로고    scopus 로고
    • Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: An updated analysis from SITS-ISTR
    • Ahmed N, Wahlgren N, Grond M, Hennerici M, Lees KR, Mikulik R, et al. Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR. Lancet Neurol 2010;9:866-74.
    • (2010) Lancet Neurol , vol.9 , pp. 866-874
    • Ahmed, N.1    Wahlgren, N.2    Grond, M.3    Hennerici, M.4    Lees, K.R.5    Mikulik, R.6
  • 23
    • 84880255298 scopus 로고    scopus 로고
    • Results of intravenous thrombolysis within 4.5 to 6 hours and updated results within 3 to 4.5 hours of onset of acute ischemic stroke recorded in the safe implementation of treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR): An observational study
    • SITS Investigators
    • Ahmed N, Kellert L, Lees KR, Mikulik R, Tatlisumak T, Toni D, SITS Investigators. Results of intravenous thrombolysis within 4.5 to 6 hours and updated results within 3 to 4.5 hours of onset of acute ischemic stroke recorded in the safe implementation of treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR): an observational study. JAMA Neurol 2013;70:837-44.
    • (2013) JAMA Neurol , vol.70 , pp. 837-844
    • Ahmed, N.1    Kellert, L.2    Lees, K.R.3    Mikulik, R.4    Tatlisumak, T.5    Toni, D.6
  • 24
    • 19744368662 scopus 로고    scopus 로고
    • Thrombolysis for acute ischemic stroke: Results of the Canadian Alteplase for Stroke Effectiveness Study
    • DOI 10.1503/cmaj.1041561
    • Hill MD, Buchan AM, Canadian Alteplase for Stroke Effectiveness Study (CASES) Investigators. Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study. CMAJ 2005;172:1307-12. (Pubitemid 40745072)
    • (2005) Canadian Medical Association Journal , vol.172 , Issue.10 , pp. 1307-1312
    • Hill, M.D.1    Buchan, A.M.2
  • 25
    • 78650248913 scopus 로고    scopus 로고
    • Thrombolysis at 3-4.5 hours after acute ischemic stroke onset-evidence from the Canadian Alteplase for Stroke Effectiveness Study (CASES) registry
    • Shobha N, Buchan AM, Hill MD. Thrombolysis at 3-4.5 hours after acute ischemic stroke onset-evidence from the Canadian Alteplase for Stroke Effectiveness Study (CASES) registry. Cerebrovasc Dis 2011;31:223-8.
    • (2011) Cerebrovasc Dis , vol.31 , pp. 223-228
    • Shobha, N.1    Buchan, A.M.2    Hill, M.D.3
  • 26
    • 84871270141 scopus 로고    scopus 로고
    • A model of cost-effectiveness of tissue plasminogen activator in patient subgroups 3 to 4.5 hours after onset of acute ischemic stroke
    • Boudreau DM, Guzauskas G, Villa KF, Fagan SC, Veenstra DL. A model of cost-effectiveness of tissue plasminogen activator in patient subgroups 3 to 4.5 hours after onset of acute ischemic stroke. Ann Emerg Med 2013;61:46-55.
    • (2013) Ann Emerg Med , vol.61 , pp. 46-55
    • Boudreau, D.M.1    Guzauskas, G.2    Villa, K.F.3    Fagan, S.C.4    Veenstra, D.L.5
  • 27
    • 84880765729 scopus 로고    scopus 로고
    • Cost-effectiveness of thrombolysis within 4.5 hours of acute ischemic stroke: Experience from Australian Stroke Center
    • Tanny SP, Busija L, Liew D, Teo S, Davis SM, Yan B. Cost-effectiveness of thrombolysis within 4.5 hours of acute ischemic stroke: experience from Australian Stroke Center. Stroke 2013;44:2269-74.
    • (2013) Stroke , vol.44 , pp. 2269-2274
    • Tanny, S.P.1    Busija, L.2    Liew, D.3    Teo, S.4    Davis, S.M.5    Yan, B.6
  • 28
    • 84879069684 scopus 로고    scopus 로고
    • Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke
    • Saver JL, Fonarow GC, Smith EE, Reeves MJ, Grau-Sepulveda MV, Pan W, et al. Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke. JAMA 2013;309:2480-8.
    • (2013) JAMA , vol.309 , pp. 2480-2488
    • Saver, J.L.1    Fonarow, G.C.2    Smith, E.E.3    Reeves, M.J.4    Grau-Sepulveda, M.V.5    Pan, W.6
  • 29
    • 84858118130 scopus 로고    scopus 로고
    • Predicting outcome of IV thrombolysis-treated ischemic stroke patients: The DRAGON score
    • Strbian D, Meretoja A, Ahlhelm FJ, Pitkäniemi J, Lyrer P, Kaste M, et al. Predicting outcome of IV thrombolysis-treated ischemic stroke patients: the DRAGON score. Neurology 2012;78:427-32.
    • (2012) Neurology , vol.78 , pp. 427-432
    • Strbian, D.1    Meretoja, A.2    Ahlhelm, F.J.3    Pitkäniemi, J.4    Lyrer, P.5    Kaste, M.6
  • 30
    • 84860223906 scopus 로고    scopus 로고
    • The iScore predicts effectiveness of thrombolytic therapy for acute ischemic stroke
    • Saposnik G, Fang J, Kapral MK, Tu JV, Mamdani M, Austin P, et al. The iScore predicts effectiveness of thrombolytic therapy for acute ischemic stroke. Stroke 2012;43:1315-22.
    • (2012) Stroke , vol.43 , pp. 1315-1322
    • Saposnik, G.1    Fang, J.2    Kapral, M.K.3    Tu, J.V.4    Mamdani, M.5    Austin, P.6
  • 32
    • 84868209961 scopus 로고    scopus 로고
    • Risk factors for intracranial hemorrhage in acute ischemic stroke patients treated with recombinant tissue plasminogen activator: A systematic review and meta-analysis of 55 studies
    • Whiteley WN, Slot KB, Fernandes P, Sandercock P, Wardlaw J. Risk factors for intracranial hemorrhage in acute ischemic stroke patients treated with recombinant tissue plasminogen activator: a systematic review and meta-analysis of 55 studies. Stroke 2012;43:2904-9.
    • (2012) Stroke , vol.43 , pp. 2904-2909
    • Whiteley, W.N.1    Slot, K.B.2    Fernandes, P.3    Sandercock, P.4    Wardlaw, J.5
  • 33
    • 84880154324 scopus 로고    scopus 로고
    • Comparison of risk-scoring systems in predicting symptomatic intracerebral hemorrhage after intravenous thrombolysis
    • Sung SF, Chen SC, Lin HJ, Chen YW, Tseng MC, Chen CH. Comparison of risk-scoring systems in predicting symptomatic intracerebral hemorrhage after intravenous thrombolysis. Stroke 2013;44:1561-6.
    • (2013) Stroke , vol.44 , pp. 1561-1566
    • Sung, S.F.1    Chen, S.C.2    Lin, H.J.3    Chen, Y.W.4    Tseng, M.C.5    Chen, C.H.6
  • 34
    • 84880794685 scopus 로고    scopus 로고
    • Glycosylated hemoglobin A1 predicts risk for symptomatic hemorrhage after thrombolysis for acute stroke
    • Rocco A, Heuschmann PU, Schellinger PD, Köhrmann M, Diedler J, Sykora M, et al. Glycosylated hemoglobin A1 predicts risk for symptomatic hemorrhage after thrombolysis for acute stroke. Stroke 2013;44:2134-8.
    • (2013) Stroke , vol.44 , pp. 2134-2138
    • Rocco, A.1    Heuschmann, P.U.2    Schellinger, P.D.3    Köhrmann, M.4    Diedler, J.5    Sykora, M.6
  • 35
    • 84880145172 scopus 로고    scopus 로고
    • External validation of the SEDAN score for prediction of intracerebral hemorrhage in stroke thrombolysis
    • Mazya MV, Bovi P, Castillo J, Jatuzis D, Kobayashi A, Wahlgren N, et al. External validation of the SEDAN score for prediction of intracerebral hemorrhage in stroke thrombolysis. Stroke 2013;44:1595-600.
    • (2013) Stroke , vol.44 , pp. 1595-1600
    • Mazya, M.V.1    Bovi, P.2    Castillo, J.3    Jatuzis, D.4    Kobayashi, A.5    Wahlgren, N.6
  • 36
    • 84878213488 scopus 로고    scopus 로고
    • Details of a prospective protocol for a collaborative meta-analysis of individual participant data from all randomized trials of intravenous rt-PA vs. Control: Statistical analysis plan for the Stroke Thrombolysis Trialists' Collaborative meta-analysis
    • Stroke Thrombolysis Trialists' Collaborative Group
    • Stroke Thrombolysis Trialists' Collaborative Group. Details of a prospective protocol for a collaborative meta-analysis of individual participant data from all randomized trials of intravenous rt-PA vs. control: statistical analysis plan for the Stroke Thrombolysis Trialists' Collaborative meta-analysis. Int J Stroke 2013;8:278-83.
    • (2013) Int J Stroke , vol.8 , pp. 278-283


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.