Impact of hyperglycemia in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: The HORIZONS-AMI trial

International Journal of Cardiology

Volumn 167, Issue 6, 2013, Pages 2572-2579

  Planer, David ^a,b   Witzenbichler, Bernhard ^c   Guagliumi, Giulio ^d   Peruga, Jan Z ^e   Brodie, Bruce R ^f   Xu, Ke ^a   Fahy, Martin ^a   Mehran, Roxana ^g   Stone, Gregg W ^a  

^a NewYork Presbyterian Hospital   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d OSPEDALI RIUNITI   (Italy)

^e MEDICAL UNIVERSITY OF LODZ   (Poland)

^f MOSES H CONE MEMORIAL HOSPITAL   (United States)

^g CARDIOVASCULAR RESEARCH FOUNDATION   (United States)

Author keywords

Diabetes; Hyperglycemia; Mortality; Primary PCI; Randomized trial; STEMI

Indexed keywords

GLUCOSE; INSULIN; ORAL ANTIDIABETIC AGENT;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR MORTALITY; CLINICAL EVALUATION; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HOSPITAL ADMISSION; HUMAN; HYPERGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

DIABETES; HYPERGLYCEMIA; MORTALITY; PRIMARY PCI; RANDOMIZED TRIAL; STEMI;

AGED; BLOOD GLUCOSE; FEMALE; HUMANS; HYPERGLYCEMIA; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES;

EID: 84883749277     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2012.06.054     Document Type: Article

References (29)

1. S.E. Capes, D. Hunt, K. Malmberg, and H.C. Gerstein Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview Lancet 355 2000 773 778
2. N.N. Wahab, E.A. Cowden, N.J. Pearce, M.J. Gardner, H. Merry, and J.L. Cox Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era? J Am Coll Cardiol 40 2002 1748 1754
3. D.S. Pinto, A.J. Kirtane, and Y.B. Pride Association of blood glucose with angiographic and clinical outcomes among patients with ST-segment elevation myocardial infarction (from the CLARITY-TIMI-28 study) Am J Cardiol 101 2008 303 307
4. M. Ishihara, E. Kagawa, and I. Inoue Impact of admission hyperglycemia and diabetes mellitus on short- and long-term mortality after acute myocardial infarction in the coronary intervention era Am J Cardiol 99 2007 1674 1679
5. M. Kosiborod, S.E. Inzucchi, and H.M. Krumholz Glucometrics in patients hospitalized with acute myocardial infarction: defining the optimal outcomes-based measure of risk Circulation 117 2008 1018 1027
6. M. Kosiborod, S.S. Rathore, and S.E. Inzucchi Admission glucose and mortality in elderly patients hospitalized with acute myocardial infarction: implications for patients with and without recognized diabetes Circulation 111 2005 3078 3086
7. C. Lazzeri, S. Valente, M. Chiostri, C. Picariello, and G.F. Gensini In-hospital peak glycemia and prognosis in STEMI patients without earlier known diabetes Eur J Cardiovasc Prev Rehabil 17 2010 419 423
8. G.W. Stone, B. Witzenbichler, and G. Guagliumi Bivalirudin during primary PCI in acute myocardial infarction N Engl J Med 358 2008 2218 2230
9. C.K. Naber, R.H. Mehta, and C. Junger Impact of admission blood glucose on outcomes of nondiabetic patients with acute ST-elevation myocardial infarction (from the German Acute Coronary Syndromes [ACOS] Registry) Am J Cardiol 103 2009 583 587
10. S. Lavi, M. Kapeliovich, and L. Gruberg Hyperglycemia during acute myocardial infarction in patients who are treated by primary percutaneous coronary intervention: impact on long-term prognosis Int J Cardiol 123 2008 117 122
11. A. Ceriello, R. Giacomello, and G. Stel Hyperglycemia-induced thrombin formation in diabetes. The possible role of oxidative stress Diabetes 44 1995 924 928
12. H. Kawano, T. Motoyama, and O. Hirashima Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery J Am Coll Cardiol 34 1999 146 154
13. T. Sakamoto, H. Ogawa, and H. Kawano Rapid change of platelet aggregability in acute hyperglycemia. Detection by a novel laser-light scattering method Thromb Haemost 83 2000 475 479
14. J.R. Timmer, J.P. Ottervanger, and M.J. de Boer Hyperglycemia is an important predictor of impaired coronary flow before reperfusion therapy in ST-segment elevation myocardial infarction J Am Coll Cardiol 45 2005 999 1002
15. K. Iwakura, H. Ito, and M. Ikushima Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction J Am Coll Cardiol 41 2003 1 7
16. P.H. McNulty, S. Pfau, and L.I. Deckelbaum Effect of plasma insulin level on myocardial blood flow and its mechanism of action Am J Cardiol 85 2000 161 165
17. U. Scherrer, D. Randin, P. Vollenweider, L. Vollenweider, and P. Nicod Nitric oxide release accounts for insulin's vascular effects in humans J Clin Invest 94 1994 2511 2515
18. F. Iliadis, N. Kadoglou, and T. Didangelos Insulin and the heart Diabetes Res Clin Pract 93 Suppl. 1 2011 S86 S91
19. K.Y. Carmen Wong, V. Wong, J.T. Ho, D.J. Torpy, M. McLean, and N.W. Cheung High cortisol levels in hyperglycaemic myocardial infarct patients signify stress hyperglycaemia and predict subsequent normalization of glucose tolerance Clin Endocrinol (Oxf) 72 2010 189 195
20. S.W. Schaffer, C.B. Croft, and V. Solodushko Cardioprotective effect of chronic hyperglycemia: effect on hypoxia-induced apoptosis and necrosis Am J Physiol Heart Circ Physiol 278 2000 H1948 H1954
21. M. Ishihara, I. Inoue, and T. Kawagoe Is admission hyperglycaemia in non-diabetic patients with acute myocardial infarction a surrogate for previously undiagnosed abnormal glucose tolerance? Eur Heart J 27 2006 2413 2419
22. R.W. Nesto, and R.M. Lago Glucose: a biomarker in acute myocardial infarction ready for prime time? Circulation 117 2008 990 992
23. A. Goyal, K.W. Mahaffey, and J. Garg Prognostic significance of the change in glucose level in the first 24 h after acute myocardial infarction: results from the CARDINAL study Eur Heart J 27 2006 1289 1297
24. K. Malmberg, L. Ryden, and H. Wedel Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity Eur Heart J 26 2005 650 661
25. K. Malmberg Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group BMJ 314 1997 1512 1515
26. N.W. Cheung, V.W. Wong, and M. McLean The hyperglycemia: intensive insulin infusion in infarction (HI-5) study: a randomized controlled trial of insulin infusion therapy for myocardial infarction Diabetes Care 29 2006 765 770
27. R. Diaz, A. Goyal, and S.R. Mehta Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction JAMA 298 2007 2399 2405
28. M. Kosiborod, and D.K. McGuire Glucose-lowering targets for patients with cardiovascular disease: focus on inpatient management of patients with acute coronary syndromes Circulation 122 2010 2736 2744
29. F.G. Kushner, M. Hand, and S.C. Smith Jr. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (updating the 2005 Guideline and 2007 Focused Update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Circulation 120 2009 2271 2306